The Neuroprotective Effect of Remote Ischemic Conditioning in Ruptured Aneurysm Coiling Therapy

The Neuroprotective Effect of Remote Ischemic Conditioning in Ruptured Aneurysm Coiling Therapy

The overall incidence of DWI positive for thromboembolic events following endovascular treatment of intracranial aneurysms is proximately 50%. Whether remote ischemic conditioning was safe and effective to reduce ischemic brain lesions on DWI after endovascular treatment of intracranial aneurysms is still unclear. The investigators' hypothesis is that remote ischemic conditioning is a safe and effective strategy to reduce new ischemic lesions in intracranial aneurysms patients undergoing endovascular treatment.

Inclusion Criteria:

• Age 18 years or older
• Ruptured brain aneurysm deemed suitable for neuroendovascular repair
• Normal baseline brain MRI
• Female subjects of childbearing potential have a negative pregnancy test.
• Signed informed consent prior to entering study

Exclusion Criteria:

• Dissecting or mycotic brain aneurysm.
• Planned endovascular vessel sacrifice as the primary modality for aneurysm treatment
• Renal insufficiency with creatinine ≥ 265 umol/L
• Severe, sustained hypertension (SBP > 185 mmHg or DBP > 110 mmHg)
• Contraindication for remote ischemic conditioning: severe soft tissue injury, fracture, or peripheral vascular disease in the upper limbs
• Pre-morbid modified Rankin scale score of greater than 1
• Patients with a pre-existing neurological or psychiatric disease that would confound the neurological or functional evaluations Patients who are unable to have an MRI scan for any reason.
• Currently participating or previously participated in any investigational drug or device study within 6 months.