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It's a prospective observational study to assess frailty and physical function
We stimate to recruit 1120 patients older tan 50 years to assess frailty and define a simplified fragility index
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HIV patients older than 50 years | Spanish cohort of patients with HIV infection older tha 50 years old. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No interventions | Other | No interventions |
|
| Measure | Description | Time Frame |
|---|---|---|
| To know the prevalence of frailty in the population over 50 years old with HIV infection according to Fried's fragility phenotype | Fragility is defined according to the 5 Fried criteria:
| Change from basal to year 5 |
| Define a new simplified fragility index for the elderly patients with HIV infection easily applicable in clinical routine practice | The simplified fragility index for the elderly patient with HIV infection can not be defined a priori, so a multivariate logistic regression analysis will be performed for those variables that are associated with fragility in the analysis univariate, which will allow us to determine the variables that are associated in a independent with fragility, which will be with which we will define the fragility index simplified. Fragility will be treated as a binary variable: pre-fragile and robust will form a group that will serve as control. The fragility phenotype defined by the 5 Fried criteria will be considered the gold standard test to measure fragility when validating the simplified fragility screening test specific for elderly patients with HIV infection that we want to define | Year 5 |
| To study the prognostic value of the CD4 / CD8 ratio in relation to frailty | Change from Basal to Year 5 | |
| Analyze the relationship between exposure time to different families of antiretroviral drugs with fragility. | Change from Basal to Year 5 | |
| Define fragility biomarkers | immunological profile, oxidative damage, microbiome. |
| Measure | Description | Time Frame |
|---|---|---|
| Know the functional situation and the risk of functional deterioration of the population over 50 years of age with HIV infection in our cohort | Year 1, year 2, year 3, year 4 and year 5 | |
| Analyze the possible association of fragility in this population group with the comorbidity and the presence of other geriatric syndromes |
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Inclusion Criteria:
Patients with confirmed HIV + infection.
Patients aged ≥ 50 years at the time of starting the study, followed in the Infectious-HIV consultations of the centers participants.
This limit has been chosen because it is accepted by the scientific community for define the elderly patient in patients with HIV infection.
Have signed the informed consent and be willing to comply with the study visits.
Exclusion Criteria:
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Patients with HIV infection older ythan 50 year sold who are followed in the consultations of the center participants
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Reina Sofia | Córdoba | Córdoba | Spain | |||
| Hospital de Donostia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36597036 | Derived | Branas F, Torralba M, Antela A, Vergas J, Ramirez M, Ryan P, Dronda F, Galindo MJ, Machuca I, Bustinduy MJ, Cabello A, Montes ML, Sanchez-Conde M; FUNCFRAIL study group. Effects of frailty, geriatric syndromes, and comorbidity on mortality and quality of life in older adults with HIV. BMC Geriatr. 2023 Jan 3;23(1):4. doi: 10.1186/s12877-022-03719-8. |
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Markers of mitochondrial function, of naive cells, memory and recent immigrants of the thymus, of immunoactivation, immunosenescence, activation / exhaustion and proliferation and Telomere measurement
| Change from Basal to Year 5 |
| Year 1, year 2, year 3, year 4 and year 5 |
| To know the prevalence of other geriatric syndromes | polypharmacy, falls, cognitive impairment, depression, risk of malnutrition. | Year 1, year 2, year 3, year 4 and year 5 |
| To know the risk of fragility fractures in the population over 50 years old with HIV infection in our cohort | Year 1, year 2, year 3, year 4 and year 5 |
| To analyze the possible association of bone fragility with the presence of the syndrome clinical of fragility in this population group | Year 1, year 2, year 3, year 4 and year 5 |
| Donostia / San Sebastian |
| Donostia |
| Spain |
| Clínico San Carlos | Madrid | Madrid | Spain |
| Hospital Ramón y Cajal | Madrid | Madrid | Spain |
| Hospital Univ. La Paz | Madrid | Madrid | Spain |
| Hospital de Santiago | Santiago de Compostela | Santiago de Compostela | Spain |
| Hospital Clínic de Valencia | Valencia | Valencia | Spain |
| Hospital Germans Trias i Pujol | Barcelona | Spain |
| Hospital de Guadalajara | Guadalajara | Spain |
| Hospital Fundación Jimenez Diaz | Madrid | Spain |
| Hospital Gregorio Marañón | Madrid | Spain |
| Hospital Infanta Leonor | Madrid | Spain |
| Hospital Puerta de Hierro | Madrid | Spain |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
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