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Rheumatoid Arthritis (RA) is an inflammatory rheumatic disease that can lead to structural damage and handicap. The RA physiopathology is multifactorial, including genetic and environmental risk factors. The identification of environmental factors implication is crucial to understand the RA mechanism, and improves the diagnosis and the treatment of the disease.
The physiopathology of RA is multifactorial, implicating genetic and environmental factors. Within the environmental factors, the exact role of psychological stress and life events on the onset of the disease is still under question. In clinical practice, patients usually report the occurrence of a stressing life event before the diagnosis of the disease (mourning, dismissal, divorce…). Nevertheless, literature reviews present some discrepancies and did not lead to a clear identification of the role of psychological stress in RA onset. This is mainly due to the evaluation methods of stress within those previous studies, considering stress as a unique response of the organism without taking into account personal, sociological, biological or environmental history. The aim of the study is to analyze the impact of stress on the RA onset within an integrative model, to evaluate patient assessment of the stress, and to present strategies to fix it.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rheumatoid Arthritis patients | patients affected by RA according to ACR/EULAR 2010 criteria, with a disease duration less than 2 years |
| |
| control patients | patients with a visceral surgery for less than 2 years (appendectomy, cholecystectomy, bowel obstruction, hernia, eventration…) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Questionnaire | Behavioral | Questionnaire |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Life events calculated over the year preceding the onset of PR symptoms | Social Readjustment Rating Scale (SRRS) | At inclusion (day 0) |
| Measure | Description | Time Frame |
|---|---|---|
| Perceived stress | Perceived Stress Scale (PSS) | At inclusion (day 0) |
| Perceived control | Multidimensional Health Locus of Control Scale (MHLCS) |
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Patients RA :
Inclusion Criteria:
Exclusion Criteria:
Control :
Inclusion Criteria:
Exclusion Criteria:
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Patients affected by RA according to ACR/EULAR 2010 criteria, with a disease duration less than 2 years
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| Name | Affiliation | Role |
|---|---|---|
| Thierry SCHAEVERBEKE, Prof | University Hospital, Bordeaux | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Bordeaux - service de rhumatologie | Bordeaux | France | ||||
| CH de Dax - service de rhumatologie |
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blood sample
| blood sample |
| Biological |
7 ml whole blood for Peripheral blood |
|
| At inclusion (day 0) |
| Perceived social support | Social Support Questionnaire (SSQ) | At inclusion (day 0) |
| State Anxiety | State-Trait Anxiety Inventory (STAI-Y-A) | At inclusion (day 0) |
| Coping | Ways of Coping Checklist Scale (WCC) | At inclusion (day 0) |
| Cytokine levels in RA patients sera | 12 months from baseline |
| Correlation between cytokine levels and RA activity | 12 months from baseline |
| Correlation between cytokine levels and stress for RA patients | 12 months from baseline |
| Identification of neuropathic pain for RA patients evalued by douleur-neuropathique 10 items questionnaire | douleur-neuropathique 10 items questionnaire providing a score between 0 and 10, with a positive threshold value beyond 4/10. | 12 months from baseline |
| Characterization of neuropathic pain for RA patients evalued by Neuropathic Pain Symptom Inventory questionnaire | Neuropathic Pain Symptom Inventory questionnaire with 12 items to complete, providing for each item the presence (or the absence) of several pain symptoms | 12 months from baseline |
| Dax |
| France |
| Hôpital Suburbain du Bouscat | Le Bouscat | France |
| CH de Libourne - service de rhumatologie | Libourne | France |
| CH de Pau - service de rhumatologie | Pau | France |
| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| D040921 | Stress Disorders, Traumatic |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
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