Glizigen® spray + Ocoxin-Visuid® oral solution

• Glizigen® spray, topical use, 2 times a day for 6 months with an interruption for 2 months at the end of the third month.
• Ocoxin®-Viusid® 60 ml daily (1 vial every 12 hours) by oral route for 8 months, preferably administered after breakfast and lunch, without interruption.

Colonoscopy. The categories will analyze as:

• Complete Response-CR (Disappearance of the initial lesion and no new lesions appear).
• Partial Response-PR (Reduction between 30 to 50% or more of the initial lesion and no new lesions appear).
• Stable disease-SD (Same morphometry or reduction of less than 30% of the initial lesion).
• Progressive Disease-PD (Increase in the diameter of the lesion The lesion extends to one or more quadrants that were not in the initial lesion. It will be considered progressive disease when at least two of the response variables are present.The variable viral load will always be present).

Histology. The categories will analyze as:

• CR (Disappearance of the initial lesion No degree of Cervical intraepithelial Neoplasia (CIN)).
• PR (Reduction of CIN to one degree or more).
• SD (Same degree of initial lesion is maintained).
• PD (Increase in one degree of the lesion of CIN or presence of histological signs of invasion] It will be considered progressive disease when at least two of the response variables are present. The variable viral load will always be present).

Virological. The categories will analyze as:

• CR (Viral genotype- VG: Negative Human Papillomavirus (HPV) detection high or low oncogenic risk and Viral load: Not detectable).
• PR (VG: No detection of viral genotypes of high oncogenic risk identified in the initial examination, but positive to HPV of low oncogenic risk Viral load: Reduction of the value of the viral load in at least one base logarithm 10).
• SD (VG: Initial genotypes are maintained Viral load: Equal result than the initial examination, no change in the viral load values).
• PD (VG: Initial genotypes or appearance of one or more oncogenic genotypes are maintained Viral load: Initial genotypes show an increase in viral load value in at least one base 10 logarithm. Other oncogenic genotypes appear with viral load values greater than or equal to 103 copies / ml.] It will be considered progressive disease when at least two of the response variables are present.The variable viral load will always be present).

Complete Response: Disappearance of the initial lesion and no new lesions appear; Partial Response: Reduction between 30 to 50% or more of the initial lesion and no new lesions appear; Stable Disease: Equal morphometry or minor reduction 30% of the initial lesion; Progressive Disease: Increased diameter of the lesion The lesion extends to one or more quadrants that were not in the initial lesion).