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A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries. Detailed questionnaires were sent every 1.5-6 months concerning water sources, fluoride exposures, dietary intakes, etc. Standardized dental exams were conducted at ~ages 5, 9, 13, 17, and 23. At about age 5, participants were invited to join the offshoot Iowa Bone Development Study. Bone densitometry assessments were conducted at ages 5, 8, 11, 13, 15, 17, 19, and 23. These included Dual-energy X-ray Absorptiometry (DXA) of hip, lumbar spine, and whole body from age 5; peripheral Quantitative Computed Tomography (pQCT) of the radius and tibia from age 11; and Multi-Detector Computed Tomography (MDCT) of the tibia from age 19. Physical activity and other factors also were assessed longitudinally.
A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries. Detailed questionnaires were sent every 1.5-6 months concerning water sources, fluoride exposures, dietary intakes, etc. Standardized dental exams were conducted at ~ages 5, 9, 13, 17, and 23. At about age 5, participants were invited to join the offshoot Iowa Bone Development Study. Bone densitometry assessments were conducted at ages 5, 8, 11, 13, 15, 17, 19, and 23. These included Dual-energy X-ray Absorptiometry (DXA) of hip, lumbar spine, and whole body from age 5; peripheral Quantitative Computed Tomography (pQCT) of the radius and tibia from age 11; and Multi-Detector Computed Tomography (MDCT) of the tibia from age 19. Physical activity and other factors also were assessed longitudinally.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Parents with newborns recruited from 1992-5 | Parents of newborns recruited from 8 Iowa hospitals in 1992-5 |
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| Measure | Description | Time Frame |
|---|---|---|
| dental fluorosis-5 | dental fluorosis exam results | age 5 |
| dental fluorosis-9 | dental fluorosis exam results | age 9 |
| dental fluorosis-13 | dental fluorosis exam results | age 13 |
| dental fluorosis-17 | dental fluorosis exam results | age 17 |
| dental fluorosis-23 | dental fluorosis exam results | age 23 |
| dental caries-5 | dental caries exam results | age 5 |
| dental caries-9 | dental caries exam results | age 5 |
| dental caries-13 | dental caries exam results | age 9 |
| dental caries-17 | dental caries exam results | age 17 |
| dental caries-23 |
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Inclusion Criteria:
Exclusion Criteria:
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newborns recruited from 8 Iowa hospitals postpartum
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| Name | Affiliation | Role |
|---|---|---|
| Steven M Levy, dds | University of Iowa | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33109505 | Derived | Marshall TA, Curtis AM, Cavanaugh JE, Warren JJ, Levy SM. Beverage Intakes and Toothbrushing During Childhood Are Associated With Caries at Age 17 Years. J Acad Nutr Diet. 2021 Feb;121(2):253-260. doi: 10.1016/j.jand.2020.08.087. Epub 2020 Oct 24. | |
| 30638821 | Derived | Marshall TA, Curtis AM, Cavanaugh JE, Warren JJ, Levy SM. Child and Adolescent Sugar-Sweetened Beverage Intakes Are Longitudinally Associated with Higher Body Mass Index z Scores in a Birth Cohort Followed 17 Years. J Acad Nutr Diet. 2019 Mar;119(3):425-434. doi: 10.1016/j.jand.2018.11.003. Epub 2019 Jan 9. |
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some data are available in NIH repository under DBGap
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some past data are there now
caries outcomes and explanatory factors
contact PI for discussions and permissions
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| ID | Term |
|---|---|
| D003731 | Dental Caries |
| D009050 | Fluorosis, Dental |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D017001 | Tooth Demineralization |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
| D000094603 | Dental Enamel Hypomineralization |
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salivary samples collected for DNA
dental caries exam results |
| age 23 |
| bone densitometry-5 | DXA scans | age 5 |
| bone densitometry-8 | DXA scans | age 8 |
| bone densitometry-11 | DXA and pQCT scans | age 11 |
| bone densitometry-13 | DXA and pQCT scans | age 13 |
| bone densitometry-15 | DXA and pQCT scans | age 15 |
| bone densitometry-17 | DXA and pQCT scans | age 17 |
| bone densitometry-19 | DXA, pQCT, and MDCT scans | age 19 |
| bone densitometry-23 | DXA, pQCT, and MDCT scans | age 23 |
| D000094602 | Developmental Defects of Enamel |
| D014071 | Tooth Abnormalities |
| D018640 | Stomatognathic System Abnormalities |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D001519 | Behavior |