This study observes a liquid skin protectant that is a polymeric-cyanoacrylate solution designed to protect intact or damaged skin due to radiation.

Inclusion Criteria:

• Age ≥ 18years.
• Patient has initial or recurrent disease
• Undergoing external beam radiotherapy at the Mayo Clinic Rochester campus Note: Patients who are undergoing concurrent chemotherapy are eligible
• Ability to complete questionnaire(s) by themselves or with assistance
• Provide informed written consent
• Willing to consent for photography of radiation field
• Available to return to Mayo Clinic in within 1 week post treatment for assessment (+/- 7 days).
• At risk for developing ≥ grade 2 dermatitis radiation as determined by treating Radiation Oncology clinician
• Biologic effective dose of >42 Gy10 as calculated using the web site EQD2.com.

Exclusion Criteria:

• Unable to provide informed consent
• Patients with active rash, pre-existing dermatitis, lupus or scleroderma within the treatment area that may make skin assessment for the study difficult
• Known history of developing an allergic reaction after using a product containing cyanoacrylate or acrylates
• Subject has a medical condition that in the opinion of the investigator should exclude him/her from participating in the study
• Subject has been enrolled in an investigational study where product was applied to the proposed study site within 30 days of the screening visit
• The skin area affected by radiation requires treatment with a concomitant medication or product (if applicable)

Radiation therapy patients