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The overall objective of this project is to identify the neural signature of the impaired ability to relate socially seen in individuals with schizophrenia. A hypothesized path from the neural processes of social cognition, to social cognition assessed behaviorally, to real-life social interactions is examined. Secondary aims are to compare electrophysiological measures of high vs low level social cognition; to develop assessment methods of real-life behavior; and to increase the ecological validity of schizophrenia research. Much research within the field is devoid of personal meaning and interpersonal context. This project's use of personalized assessment allows for an ecologically valid approach to the social deficits of schizophrenia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SZ | Individuals with a diagnosis of schizophrenia |
| |
| HC | Healthy control participants |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| This is not an intervention study | Other | This is not an intervention study |
|
| Measure | Description | Time Frame |
|---|---|---|
| Neurophysiology: EEG | EEG mu suppression paradigm using point-light displays | 1 day (when assessed) |
| Neurophysiology: ERP | ERP mentalizing paradigm (perspective taking) | 1 day (when assessed) |
| Cognition | Matrics Consensus Cognitive Battery | 1 day (when assessed) |
| Negative symptoms: clinician-rated | Positive and Negative Syndrome Scale (PANSS) 2. Objectively assessed using computerized software (FaceReader, PRAAT) of video-taped personal narratives produced by the participants | 1 day (when assessed) |
| Negative symptoms: objective 1 | FaceReader | 1 day (when assessed) |
| Negative symptoms: objective 2 | PRAAT | 1 day (when assessed) |
| Social cognition: complex ToM | Movie for the Assessment of Social Cognition | 1 day (when assessed) |
| Social cognition: low level ToM | The Hinting Task | 1 day (when assessed) |
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Inclusion Criteria:
Exclusion Criteria
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Individuals with a diagnosis of schizophrenia will be compared to healthy control participants
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D060825 | Cognitive Dysfunction |
| D066107 | Social Skills |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
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| Social cognition: facial emotion perception |
Pictures of Facial Affect |
| 1 day (when assessed) |
| Social cognition: body language reading | Emotion in Biological Motion test | 1 day (when assessed) |
| Functioning | Social Functioning Scale (SFS). Seven scales that can be combined into a total score. Mean score in a schizophrenia population = 100, SD = 15. For both the seven scales and the total score. | 1 day (when assessed) |
| Real-world behaviour | Day Reconstruction Method | 1 day (when assessed) |
| Real-world social interactions | Video-ethnography | 1 day (when assessed) |
| D012919 | Social Behavior |
| D001519 | Behavior |