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Optical coherence tomography is a non-invasive and non-contact imaging modality that enables two-dimensional cross-sectional and three-dimensional volumetric imaging of tissue architecture.
It has evolved over the past decade as one of the most important ancillary tests in ophthalmic practice. It is a noninvasive imaging technique and provides high resolution, cross-sectional images of the retina, the retinal nerve fiber layer and the optic nerve head. With axial resolution in the 5-7 μm range, it provides close to an in-vivo 'optical biopsy' of the retina. Optical coherence tomography employs light from a broadband light source, which is divided into a reference and a sample beam, to obtain a reflectivity versus depth profile of the retina. The light waves that are back scattered from the retina, interfere with the reference beam, and this interference pattern is used to measure the light echoes versus the depth profile of the tissue in vivo.
Recently, a new type of optical coherence tomography instrument, called a swept source optical coherence tomography, was introduced. The Swept source optical coherence tomography uses a tunable laser (swept-source) as a light source with a longer wavelength that allows the light to penetrate deeper into tissues than the conventional spectral domain optical coherence tomography instruments. This, then, enabled the imaging of the choroid.
Because choroidal abnormalities such as vascular hyperpermeability, vascular changes, loss and thinning are critical to the onset and progression of many ocular diseases, ophthalmologists and researchers are shifting their interest to the choroidal abnormalities.
Being a major vascular layer of the eye , choroid plays an important role in ocular health, and is involved in the pathogenesis of many intraocular diseases such as age-related macular degeneration , polypoidal choroidal vasculopathy , central serous chorioretinopathy and myopic macular degeneration. Accurate measurement of choroidal thickness in vivo is an essential step in monitoring disease onset and progression that lead to choroidal thinning. Based on histologic study, choroidal thickness ranges from 170 to 220 um.
These disorders show the need for understanding the choroidal structure in ocular diseases and the importance of having database of choroidal thickness.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study group | 97 eye of 49 normal Egyptian volunteers were divided into groups according to age, AL, SE of refractive error, minimum corneal thickness (MCT) and mean corneal power as follow: Age into 3 groups: Group A: from 18 to 30 years old Group B: from 31 to 40 years old Group C: > 40 years old Axial length into 3 groups: Group A: from 22 to less than 24 mm Group B: from 24 to 26 mm Group C: > 26 mm Spherical equivalent of refractive error into : Group A : from zero to - 2 D Group B : from - 2 to > - 4 D Group C : from - 4 to > - 6 D Group D: from - 6 to - 8 D Minimum corneal thickness (MCT) into 3 groups: Group i: < 500 um Group ii: from 500 to 540 um Group iii: > 540 um Refractive power of cornea (Mean K) into 3 groups: Group 1: 41 to less than 44 D Group 2: 44 to 46 D Group 3: > 46 D |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Swept source optical coherence tomography | Device | Measurement of choroidal thickness in myopic patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison between choroidal thickness and myopia | Analysis of choroidal thickness measured by swept source optical coherence tomography and the degree of myopia | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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100 case of age from 18 to 40 years old of myopic refraction from zero to -8 diopter , minimum corneal thickness from 500 to 540 micrometer , refractive power of cornea more than 41 diopter and axial length from 22 to 26 millimeter
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AssiutU | Asyut | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19952997 | Background | Sull AC, Vuong LN, Price LL, Srinivasan VJ, Gorczynska I, Fujimoto JG, Schuman JS, Duker JS. Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness. Retina. 2010 Feb;30(2):235-45. doi: 10.1097/IAE.0b013e3181bd2c3b. |
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| ID | Term |
|---|---|
| D007676 | Kidney Failure, Chronic |
| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
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| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |