Myeloid-derived Suppressor Cells in Sepsis

The Roles of MDSCs (Myeloid-derived Suppressor Cells) in Adult Patients With Sepsis.

This study is designed for septic patients, to isolate MDSCs and the correlation of prognosis of sepsis. The purpose of this study hopes to explore the phenomenon and possible mechanisms of MDSCs in patients with severe sepsis.

Inclusion Criteria:

• Patients must have known origin of infection .
• Systemic inflammatory response syndrome.

Exclusion Criteria:

• age less than 18 years
• pregnancy
• known anaphylactoid reaction to colloid fluids
• a life expectancy less than 24 hours,
• inability to provide informed, written consent
• Patients receiving nephrotoxic drugs,
• admitted to the hospital following a surgical procedure,
• sepsis more than 72 hours when screening .