Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Distraction osteogenesis is a powerful technique for creating new bone during significant lengthening of the mandible without the need for bone grafting and associated donor site morbidity.
The idea of distraction osteogenesis was largely abandoned by many until the 1950s. Ilizarov minimized complications by performing a corticotomy with minimal disruption of the surrounding blood supply and using a system of tension ring fixators to control the distraction in multiple planes. Through a series of experimental studies and clinical applications, Ilizarov established the foundation of distraction osteogenesis and its role in orthopedic management.
Applications in craniofacial surgery were first seen in 1973, when Synder et al applied the approach to mandibular lengthening in a canine animal model. Almost another 20 years passed before McCarthy and colleagues published, in 1992, the first report of mandibular lengthening in 4 children with congenital mandibular deficiency, 3 with hemifacial microsomia, and 1 with Nager syndrome. Thereafter, its role rapidly expanded to the midface and nearly all classic approaches to craniofacial reconstruction.
In general, mandibular distraction can be performed in the ramus for ramus lengthening, in the mandibular angle for downward and forward advancement, or in the mandibular body. Ramus or gonial angle distraction are mainly used to treat facial asymmetries as in hemifacial macrosomia.
Severe mandibular retrognathia can be classified as congenital or acquired. Congenital abnormalities that are associated with severe mandibular retrognathia or micrognathia include craniofacial syndromes such as hemifacial microsomia, Pierre-Robin syndrome, Treacher-Collins syndrome, and Nager syndrome. Adult patients with craniofacial syndromes may have undergone previous surgery at an earlier age, but unfavorable postsurgical growth or skeletal relapse may have occurred.
Severe mandibular retrognathia also can develop following maxillofacial trauma and mandibular fractures, which may have occurred in an adult or as a child Condylar fractures occurring at an early age can result in subsequent bony and/or fibrous temporomandibular joint ankylosis and/or deficient mandibular growth, also adult patients with complications from previous mandibular tumor resection and reconstruction can also present with acquired severe mandibular retrognathia that may require distraction osteogenesis as well.
Despite the advantages of extra-oral distraction devices in the hands of clinicians (application for very small children, simplicity of attachment, ease of manipulation, bidirectional and multidirectional dis- traction), patients are apprehensive about wearing bulky external appliances because of the social inconvenience and the potential of permanent facial scars, these disadvantages and limitations were the primary force driving the evolution of mandibular lengthening and widening toward the development of intra-oral devices.
However nowadays both internal and external distractors are used in a variety of indications in these cases each of the two types of distractor devices has its own advantages and disadvantages.
Aim of the work:
The aim of this study is to compare external and internal distraction devices for mandibular lengthening in terms of bone lengthening, patient comfort, and complications.
The study will be conducted on 30 patients who are suffering mandibular problems either congenital acquired or post tumor mandibular resection that requires lengthening of the mandible, attending the outpatient clinic of Plastic Surgery Department in Ain Shams University Hospital & Assiut University Hospital.
Preoperative assessment:
Principles of the operation:
Postoperative management and assessment:
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| I-A Internal distraction | Active Comparator | Internal osteogenesis distractor in congenital mandibular deformities in patients in growing age. |
|
| I-A External distraction | Active Comparator | External osteogenesis distractor in congenital mandibular deformities in patients in growing age. |
|
| I-B Internal distraction | Active Comparator | Internal osteogenesis distractor in congenital mandibular deformities in adult patients. |
|
| I-B External distraction | Active Comparator | External osteogenesis distractor in congenital mandibular deformities in adult patients. |
|
| II-A Internal distraction | Active Comparator | Internal osteogenesis distractor in acquired mandibular deformities in patients in growing age |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Internal Osteogenesis distractor | Device | Internal distraction osteogenesis in mandible |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of bone formation | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Failure | Failure of distraction will be assessed by the amount of bone formed in mm and the target rate of bone lenghtening to be achieved... e.g.. if the target is to lengthen 20mm we consider failure if the bone lengthening is less than 20mm | 1 month, 3months, 6months |
| Complications |
Not provided
Inclusion Criteria:
Exclusion Criteria:
1. Patients with systemic illness as cardiac diseases, or mental disorders & hepatic patients (generally debilitating diseases).
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ehab Ragab, M.Sc | Contact | +201006942649 | ehab.m.ragab88@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Assem Kamel, MD | Assiut University | Principal Investigator |
| Osama Taha, MD | Assiut University | Study Chair |
| Awny Askalany, MD |
Not provided
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 7595803 | Background | Rachmiel A, Levy M, Laufer D. Lengthening of the mandible by distraction osteogenesis: report of cases. J Oral Maxillofac Surg. 1995 Jul;53(7):838-46. doi: 10.1016/0278-2391(95)90346-1. No abstract available. | |
| 9590345 | Background | Kaban LB, Padwa BL, Mulliken JB. Surgical correction of mandibular hypoplasia in hemifacial microsomia: the case for treatment in early childhood. J Oral Maxillofac Surg. 1998 May;56(5):628-38. doi: 10.1016/s0278-2391(98)90465-7. No abstract available. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D008844 | Micrognathism |
| D063173 | Retrognathia |
| D005146 | Facial Asymmetry |
| ID | Term |
|---|---|
| D007569 | Jaw Abnormalities |
| D007571 | Jaw Diseases |
| D009140 | Musculoskeletal Diseases |
| D019767 | Maxillofacial Abnormalities |
Not provided
Not provided
Cohort prospective study model comparing two different techniques for distraction osteogenesis in 4 different subgroups
Not provided
Not provided
Not provided
Not provided
| II-A External distraction |
| Active Comparator |
External osteogenesis distractor in acquired mandibular deformities in patients in growing age |
|
| II-B Internal distraction | Active Comparator | Internal osteogenesis distractor in acquired mandibular deformities in Adult patients. |
|
| II-B External distraction | Active Comparator | External osteogenesis distractor in acquired mandibular deformities in Adult patients. |
|
| External Osteogenesis distractor | Device | External distraction osteogenesis in mandible |
|
infection will be assessed for discharge around the pins if fever is present after operation this will be considered as infection from surgery, post-operative scars wether the scar is depressed hypertrophic or keloid forming scar, loosening of the pins wehter they remained in place or otherwise they are loosened |
| 1 week |
| Assiut University |
| Study Chair |
| Ehab Ragab, M.Sc | Assiut University | Study Director |
| D019465 |
| Craniofacial Abnormalities |
| D009139 | Musculoskeletal Abnormalities |
| D009057 | Stomatognathic Diseases |
| D018640 | Stomatognathic System Abnormalities |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D008336 | Mandibular Diseases |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |