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Comparison of the effectiveness of povidone-iodine douching and painting for reducing febrile morbidity after total abdominal hysterectomy
Total abdominal hysterectomy (TAH) is the most common gynecologic operation worldwide. The two most common complications after TAH are febrile and infectious morbidities, incidence varying between 5 and 50 percent. After performing TAH, vaginal canal must be breached and closed to be blind-pouch stump. Routing vaginal douching at the night before and on the morning of the surgical date, and intra-operative painting are routinely practiced. However, no good quality of evidence base supports the effectiveness of vaginal douching and painting in preventing febrile and infectious morbidities after TAH.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control-douching group | No Intervention | No preoperative vagina douching | |
| Control-painting group | No Intervention | No intra-operative vagina painting | |
| Vaginal douching group | Experimental | Preoperative vaginal douches with povidone-iodine solution |
|
| Vaginal painting group | Experimental | Intra-operative vaginal painting with povidone-iodine solution |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vagina douching | Procedure | Vaginal douches with 1000 ml of 1% povidone-iodine solution on the night before surgery and again on the morning of surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Febrile morbidity | Defined as the presence of an oral temperature > 38 o C (100.4 o F) on two occasions at least 4 hours apart in the post-operative period excluding the first 24 hours | Day 1-7 after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Vaginal cuff infection | Defined as redness, tenderness, infiltration or abscess at vaginal cuff | 2 weeks after surgery |
| Other infectious morbidities | Defined by the presence of a urinary tract infection, abdominal wound infection, or pneumonitis; urinary tract infection defined as symptomatic infection with a mid-steam urine specimen showed bacterial growth > 105 bacteria/ml of urine; surgical wound infection defined as redness, tenderness, infiltration or abscess; pneumonitis defined as fever, physical and radiological findings of consolidation |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rajavithi hospital | Bangkok | 10400 | Thailand |
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Factorial 2-by-2 open labeled randomised controlled trial
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| Vagina painting | Procedure | Vaginal painting of vagina stump after hysterectomy with 10% povidone-iodine solution 30 ml |
|
| 2 weeks after surgery |