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Alopecia areata (AA) presents with circumscribed patches of non-scarring hair loss. It inflects a significant psychological and social burden. Many treatment options are used for the treatment of AA. Randomized controlled trials comparing intralesional and topical therapy and comparing combinations are few.
The aim of this work is to evaluate the efficacy of combined topical 5% minoxidil and potent topical corticosteroid therapy compared to intralesional triamcinolone injection in alopecia areata
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intralesional group | Active Comparator | intralesional triamcinolone acetonide 5 mg/ml monthly |
|
| Topical therapy group | Active Comparator | Minoxidil 5% topical solution applied twice daily and topical clobetasol propionate 0.05% cream applied once daily every night |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Triamcinolone Acetonide | Drug |
| ||
| Minoxidil 5 % Topical Spray |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical assessment using SALT score (Severity of Alopecia Tool score) | SALT score is a quantitative assessment scale for the evaluation of percentage of scalp hair loss. The percent surface area of each of the 4 scalp is determined: Vertex (top): 40% (0.4) of scalp surface area; each side of scalp (right and left profile): each 18% (0.18) of scalp surface area; posterior aspect (back) of scalp: 24% (0.24) of scalp surface area. The percentage of hair loss in any of these 4 aspects is calculated as the percentage of hair loss multiplied by percent surface area of the scalp in that area. SALT score is the sum of product of each section in the above mentioned areas. SALT score is calculated before and after therapy. Lowest value: 0%: indicates abscence of clinical disease, Highest value: 100%: indicate 100% affection of the scalp | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Dermoscopic evaluation | Dermoscopic assessment of the scalp is performed using DermaLite II Pro HR dermoscope, Germany. Dermoscopic examination is graded according to a scale provided by Trink and colleagues (2013). The percentage of dystrophic hairs was evaluated on a 4-point scale as followed:
|
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nermine H El-Eishi, MD | Cairo University | Study Chair |
| Heba M Mashaly, MD | Cairo University | Principal Investigator |
| Solwan I El-Samanoudy, MD | Cairo University | Principal Investigator |
| Mona MI ElKalioby, MD | Cairo University | Principal Investigator |
| Olfat G Shaker, MD | Cairo University | Principal Investigator |
| Rania M Abdel-Hay, MD | Cairo University | Principal Investigator |
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| ID | Term |
|---|---|
| D000506 | Alopecia Areata |
| ID | Term |
|---|---|
| D000505 | Alopecia |
| D007039 | Hypotrichosis |
| D006201 | Hair Diseases |
| D012871 | Skin Diseases |
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| ID | Term |
|---|---|
| D014222 | Triamcinolone Acetonide |
| D008914 | Minoxidil |
| D002990 | Clobetasol |
| ID | Term |
|---|---|
| D014221 | Triamcinolone |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 |
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| Drug |
|
| clobetasol propionate | Drug |
|
| 3 months |
| Quantitative measurement of Transforming growth factor-beta 1 (TGF-β1) | ELISA | 3 months |
| Quantitative measurement of Interleukin-23 (IL-23) | ELISA | 3 months |
| D017437 |
| Skin and Connective Tissue Diseases |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D011743 | Pyrimidines |
| D001623 | Betamethasone |