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The study was concluded as planned upon reaching its predetermined endpoint, which included the completion of data collection and achievement of the necessary sample size for statistical significance.
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| Name | Class |
|---|---|
| Shanghai High-risk Infants Early Intervention Center | UNKNOWN |
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There have been many studies on the use of running training in older children to improve gait development in children with cerebral palsy. The aim of our study was to conduct early treadmill training in infants who were highly suspected of cerebral palsy and to follow up on their long-term gait development.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| intervention group | Experimental | Baby treadmill + conventional physical rehabilitation training |
|
| positive control group | Active Comparator | Conventional physical rehabilitation training only |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Baby treadmill | Device | The newborns who received treadmill intervention were stimulated by running 3 times a week for a total of 10 minutes each time (complete in 5 cycles, 2 minutes per cycle, 2 minutes after the completion of one cycle and rest for 2 minutes to start the next cycle). Until the completion and completion of the five cycles). During the remaining four days of each week, other physical rehabilitation training is carried out by the rehabilitator in accordance with the established rehabilitation plan. The stimulation of running lasted from 3 months of corrected gestational age to being able to walk alone for 3 steps or to correct for 18 months. |
| Measure | Description | Time Frame |
|---|---|---|
| step frequency | This variable is a number that records the infants' number of coordinated gaits in all gait training processes. | The length of time from birth to the corrected age of 18 months |
| age of onset of independent walking | This variable is a gait parameter, recording a point in time the baby will start walking independently. | The length of time from birth to the corrected age of 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| age of onset of walking with assistance | This variable is a gait parameter, recording a point in time the baby will start walking with assistance. | The length of time from birth to the corrected age of 2 years |
| step length |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Children Hospital of Fudan University | Shanghai | Shanghai Municipality | 201102 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26828941 | Result | Vasudevan EV, Patrick SK, Yang JF. Gait Transitions in Human Infants: Coping with Extremes of Treadmill Speed. PLoS One. 2016 Feb 1;11(2):e0148124. doi: 10.1371/journal.pone.0148124. eCollection 2016. | |
| 25782975 | Result | Teulier C, Lee DK, Ulrich BD. Early gait development in human infants: Plasticity and clinical applications. Dev Psychobiol. 2015 May;57(4):447-58. doi: 10.1002/dev.21291. Epub 2015 Mar 18. |
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Parallel Assignment All subjects were divided into two groups: intervention group A (treadmill intervention + routine physical rehabilitation therapy) and positive control group (receiving routine physical rehabilitation therapy only).
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|
| Conventional physical rehabilitation training | Behavioral | Suitable for general physical rehabilitation training of all infants with cerebral palsy. |
|
The length of displacement formed by the same foot after completing a gait.
| The length of time from birth to the corrected age of 18 months |
| step width | The vertical distance between the parallel lines of two medial plantar edges | The length of time from birth to the corrected age of 18 months |
| gait double-limb support | The percentage of two-limb support gait in the whole training process. | The length of time from birth to the corrected age of 18 months |
| gait ankle plantar flexion | The percentage of gait ankle plantar flexion in the whole training process. | The length of time from birth to the corrected age of 18 months |
| toe-off | The percentage of toe-off gait in the whole training process. | The length of time from birth to the corrected age of 18 months |
| gait ankle dorsiflexion | The percentage of ankle dorsiflexion gait in the whole training process. | The length of time from birth to the corrected age of 18 months |
| 25644966 | Result | Siekerman K, Barbu-Roth M, Anderson DI, Donnelly A, Goffinet F, Teulier C. Treadmill stimulation improves newborn stepping. Dev Psychobiol. 2015 Mar;57(2):247-54. doi: 10.1002/dev.21270. Epub 2015 Feb 2. |
| 25123212 | Result | de Klerk CC, Johnson MH, Heyes CM, Southgate V. Baby steps: investigating the development of perceptual-motor couplings in infancy. Dev Sci. 2015 Mar;18(2):270-80. doi: 10.1111/desc.12226. Epub 2014 Aug 13. |
| 24136687 | Result | Madhavan S, Campbell SK, Campise-Luther R, Gaebler-Spira D, Zawacki L, Clark A, Boynewicz K, Kale D, Bulanda M, Yu J, Sui Y, Zhou XJ. Correlation between fractional anisotropy and motor outcomes in one-year-old infants with periventricular brain injury. J Magn Reson Imaging. 2014 Apr;39(4):949-57. doi: 10.1002/jmri.24256. Epub 2013 Oct 17. |
| 24012586 | Result | Angulo-Barroso RM, Tiernan C, Chen LC, Valentin-Gudiol M, Ulrich D. Treadmill training in moderate risk preterm infants promotes stepping quality--results of a small randomised controlled trial. Res Dev Disabil. 2013 Nov;34(11):3629-38. doi: 10.1016/j.ridd.2013.07.037. Epub 2013 Sep 4. |
| ID | Term |
|---|---|
| D020925 | Hypoxia-Ischemia, Brain |
| D007969 | Leukomalacia, Periventricular |
| D007647 | Kernicterus |
| D007003 | Hypoglycemia |
| D002544 | Cerebral Infarction |
| ID | Term |
|---|---|
| D002545 | Brain Ischemia |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D002534 | Hypoxia, Brain |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D000860 | Hypoxia |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D004678 | Encephalomalacia |
| D007235 | Infant, Premature, Diseases |
| D007232 | Infant, Newborn, Diseases |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D001928 | Brain Diseases, Metabolic |
| D004899 | Erythroblastosis, Fetal |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D007154 | Immune System Diseases |
| D006932 | Hyperbilirubinemia |
| D010335 | Pathologic Processes |
| D044882 | Glucose Metabolism Disorders |
| D020520 | Brain Infarction |
| D020521 | Stroke |
| D007238 | Infarction |
| D007511 | Ischemia |
| D009336 | Necrosis |
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