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| Name | Class |
|---|---|
| Nile Ivf Center, Cairo, Egypt | OTHER |
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IVF/ICSI patients who had difficult mock embryo transfer on the day of ovum pick up. Will be randomly assigned into two groups; group A will receive 100mg indomethacin rectal suppository 1-2 hours before ET and group B will not receive indomethacin
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A (Indomethacin) | Active Comparator | All patient had long stimulation protocol and IVF/ICSI. After mock embryo transfer women with any degree of difficulty will receive Indomethacin 100Mg Suppository 1-2 hours before embryo transfer. |
|
| Group B (Control) | Placebo Comparator | All patient had long stimulation protocol and IVF/ICSI. After mock embryo transfer women with any degree of difficulty will not receive any medications before embryo transfer. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Indomethacin 100Mg Suppository | Drug | Indomethacin 100Mg Suppository will be given 1 to 2 hours before embryo transfer in cases with difficult mock embryo transfer in the active comparator group. |
| Measure | Description | Time Frame |
|---|---|---|
| Implantation rate | the number of total gestational sacs divided by the total number of embryos transferred. | 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate | Presence of fetal pulsations after 2 weeks from the positive pregnancy test. | 6 weeks |
| Ongoing pregnancy rate | Pregnancies continuing beyond 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
Repeated IVF failure.
Past history of allergy to NSAID, bronchial asthma , peptic ulcer or inflammatory bowel disease.
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| Name | Affiliation | Role |
|---|---|---|
| Sarwat Ahawany, MD | Cairo University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nile IVF center | Giza | 12411 | Egypt |
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| ID | Term |
|---|---|
| D007213 | Indomethacin |
| D013488 | Suppositories |
| ID | Term |
|---|---|
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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|
| IVF/ICSI | Procedure | patients received induction with the long agonist stimulation protocol. Followed by ovum pickup and embryo transfer. Only those with difficult mock embryo transfer will be recruited in this study. |
|
| 12 weeks |
| D004304 | Dosage Forms |
| D004364 | Pharmaceutical Preparations |