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In the Ghent University, an upgrade of the MRI-scanner used for research from Siemens Trio Tim to Siemens Prisma Fit is planned in the near future. As a change of MRI hard- and software might influence brain images, it is necessary to evaluate the images before and after the upgrade.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy volunteers | Experimental | six healthy volunteers: 3 male (age 20-40; 40-60 and 60+) and 3 female (age 20-40; 40-60 and 60+) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnetic Resonance Imaging | Device | Brain imaging using magnetic resonance imaging, using several MRI sequences: structural imaging (grey matter, using T1-imaging), cerebral perfusion using arterial spin labeling), functional and effective connectivity (using resting-state functional MRI), white matter tracts (using diffusion imaging), white matter lesions (using Fluid-attenuated inversion recovery MRI (FLAIR)) and microbleeds (using Susceptibility weighted imaging (SWI)) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in grey matter volume before versus after MRI-upgrade | 7 months, 4 scan sessions of max 1 hour | |
| Change in cerebral perfusion (ml/100g/min) using Arterial Spin Labeling before versus after MRI-upgrade | 7 months, 4 scan sessions of max 1 hour | |
| Change in arterial transit times before versus after MRI-upgrade | 7 months, 4 scan sessions of max 1 hour | |
| Change in functional connectivity (fc) using Resting State functional MRI before versus after MRI-upgrade | 7 months, 4 scan sessions of max 1 hour | |
| Change in effective connectivity using resting state functional MRI before versus after MRI-upgrade | 7 months, 4 scan sessions of max 1 hour | |
| Change in white matter diffusion before versus after MRI-upgrade | 7 months, 4 scan sessions of max 1 hour | |
| Difference in image quality of FLAIR image before versus after MRI-upgrade | 7 months, 4 scan sessions of max 1 hour | |
| Difference in image quality of SWI image before versus after MRI-upgrade | 7 months, 4 scan sessions of max 1 hour |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eric Achten, PhD | University Hospital, Ghent | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ghent University | Ghent | 9000 | Belgium |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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