Gastric and Autonomic Functions in Patients With Intragastric Balloon

Gastric and Autonomic Functions in Patients With Intragastric Balloon

The study aims to measure the effect of intragastric balloon on gastric function, particularly gastric accommodation and pace making, and the possible underlying changes in autonomic function

The intragastric balloon is a space-occupying device that is hypothesized to function by inducing early satiety. Additionally, insertion of an intragastric balloon causes delayed gastric emptying; longer gastric emptying times after balloon insertion are correlated with more weight loss. The exact mechanism of function, however, is not clear and likely multifactorial. The investigators hypothesize that the intragastric balloon causes weight loss by affecting gastric and autonomic function, including pace-making and accommodation, and that the difference in responsiveness among patients may be mediated by differences in gastric function.

Inclusion Criteria:

• Patients scheduled to undergo intragastric balloon implantation
• Ability to comply to study schedule.

Exclusion Criteria:

• Unable to give informed consent
• Currently taking prokinetic, anticholinergic or dopaminergic agents which could potentially modify gastric motility
• Have a history of bariatric or gastrointestinal surgery
• Pregnant or preparing to conceive a child.