Effect of Lactobacillus Rhamnosus on Serum Uremic Toxins in Hemodialysis

Effect of Lactobacillus Rhamnosus on Serum Uremic Toxins (Phenol and P-Cresol ) in Hemodialysis Patients: A Double Blind Randomized Clinical Trial

Uremic toxins such as p-cresol and phenol are suggested to be associated with higher mortality in hemodialysis patients. The aim of this study was to investigate the effects of probiotics on serum p-cresol level in hemodialysis patients.

Overall, 42 hemodialysis patients (10 women and 32 men) were divided randomly into the Lactobacillus rhamnosus group (21 patients) and the placebo group (21 patients).

Inclusion Criteria:• Age more than 20 years

• Acceptable performance of alimentary system
• Ability to drink at least 200 ml of water per day
• No history of being allergic to fungi and yeast
• Absence of acute medical illness
• life expectancy more than 3 months
• Accept and sign the consent

Exclusion Criteria:

• Patient's unwillingness to participate in the study
• History of smoking, peritoneal dialysis (PD) or previous kidney transplantation
• Lactation or pregnancy
• Drug history including antibiotics, prebiotics, probiotics, herbal drugs, psychedelic drugs, flavors.