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It has been largely demonstrated that iv dexamethasone prolongs the duration of analgesia after peripheral nerve block. However, data are missing regarding the duration of analgesia after spinal block. The objective of this randomized controlled double-blinded trial is to assess whether intravenous dexamethasone administered after a spinal block, before the surgery would prolong sensory block characteristics without impacting the motor block duration.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexamethasone | Active Comparator | Intravenous injection of 0.15 mg/kg of dexamethasone before the surgery. |
|
| Placebo | Placebo Comparator | Intravenous injection of NaCl 0,9% before the surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexamethasone | Drug | Intravenous injection of 0.15 mg/kg of dexamethasone before the surgery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Duration of sensory block (minutes) | Time interval between injection of the local anaesthetic and the regression of 2 dermatoma, compared to the highest dermatoma reached | Postoperative day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Highest dermatoma reached (level) | Postoperative day 0 | |
| Onset time between injection and highest dermatoma (minutes) | Postoperative day 0 | |
| Total duration of the sensory block (minutes) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Universitaire Vaudois and University of Lausanne | Lausanne | Canton of Vaud | 1011 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36966023 | Derived | Bikfalvi A, Hofmann G, Bashawyah A, Rossel JB, Gonvers E, Albrecht E. Sensory block duration after spinal anaesthesia supplemented with intravenous dexamethasone: a randomised controlled double-blinded trial. Br J Anaesth. 2023 Jun;130(6):780-785. doi: 10.1016/j.bja.2023.02.027. Epub 2023 Mar 23. |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| D007869 | Leg Injuries |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D003907 | Dexamethasone |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
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| NaCl 0.0308 MEQ/ML Injectable Solution | Drug | Intravenous injection of NaCl 0.9% before the surgery. |
|
| Postoperative day 0 |
| Total duration of the motor block (minutes) | Postoperative day 0 |
| Time to the first analgesic request (minutes) | Postoperative day 0 |
| Cumulative consumption of morphine (mg) | Postoperative days 0, 1 and 2 |
| Pain score | Numeric rating scale (0-10) | Postoperative days 0, 1 and 2 |
| Rate of postoperative nausea and vomiting | YES/NO | Postoperative day 0, 1 and 2 |
| Rate of pruritus | YES/NO | Postoperative day 0, 1 and 2 |
| Rate of urinary retention | YES/NO | Postoperative day 1 and 2 |
| Satisfaction level | Numeric rating scale (0-10) | Postoperative day 2 |
| Length of stay | Days | up to 14 days |
| Persistent pain | YES/NO | 3 and 6 postoperative months |
| Pain score if persistent pain | Numeric rating scale (0-10) | 3 and 6 postoperative months |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D014947 | Wounds and Injuries |
| D000072473 |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |