The present research aims to collect virological and clinical data on hepatitis E virus (HEV) infections, either in acute or chronic forms of HEV infection in North-Eastern France, with liver- or non liver-related symptoms, plus data on HEV circulation in the outside environment. The purpose of this study is to improve the diagnosis and care of HEV-infected patients, as well as the preventive features to take into account in order to avoid food- and environment-borne infections. At last, we will investigate HEV molecular characteristics, with the hypothesis that some advantageous HEV strains coul be more pathogenic for some tissues and/or organs.

Inclusion Criteria:

• HEV-infected patients, with hepatitis and/or neurological and/or renal symptoms

Exclusion Criteria:

• Patients, with hepatitis and/or neurological and/or renal symptoms, infected by other viruses leading to hepatitis (hepatitis B, hepatitis C, hepatitis A ...)

Inclusions during 2 years (2018-2019):

• HEV infection, liver-related syndroms (either acute or chronic), n=20
• HEV-infection, neurological (n=5; controls n=5) or renal syndroms (5-10; controls n= 5-10)