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| ID | Type | Description | Link |
|---|---|---|---|
| P20GM109097 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of General Medical Sciences (NIGMS) | NIH |
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The process by which the body responds to stressors to maintain homeostasis is called allostasis and is dependent on the integrated function of the nervous, endocrine, and immune systems. ACEs adversely affect these system, cause allostatic load, and can modify development of allostatic systems. However, the central hypothesis is that exercise can reduce allostatic load by positively augmenting function of each of these three systems. No previous studies have examined the effects of structured exercise interventions in individuals with ACEs. The investigators are studying the effects of 8-weeks of structured resistance and aerobic exercise on biomarkers related to nervous, endocrine, immune, and metabolic function and several clinical outcomes in young adult women with ACEs. The specific aims will test several hypotheses, and are as follows: SPECIFIC AIM 1: Conduct a feasibility study to explore whether progressive, structured exercise can help mitigate the adverse physiological effects of stress and trauma early in life. SPECIFIC AIM 2: Determine whether progressive, structured exercise can help improve health-related quality of life, anxiety, and traits like hope, self-efficacy, or self-control, resilience. SPECIFIC AIM 3: Determine whether the type and timing of exposure to ACEs has a significant influence on the severity of psychopathology and long-term physiological response to ACEs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ACE - Exercise Group | Experimental | Participants with ACE scores of 4 or higher who will undergo exercise training for the duration of the study (experimental). |
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| ACE - Non-Exercise Group | No Intervention | Participants with ACE scores of 4 or higher who will not undergo exercise training for the duration of the study (+ control). | |
| Non-ACE - Non-Exercise Group | No Intervention | Participants with ACE scores of 0 who will not undergo exercise training for the duration of the study (- control). |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Behavioral | Participants assigned to the exercise group will undergo structured, progressive resistance and aerobic exercise for 8 weeks. Resistance training and aerobic training will each be completed twice weekly for a total of 16 resistance and 16 aerobic exercise training sessions. |
| Measure | Description | Time Frame |
|---|---|---|
| C-reactive protein | C-reactive protein concentrations (mg/L) will be examined from blood samples taken before- and after- the 8-week training or control period. | 8-weeks |
| Brain-Derived Neurotrophic Factor | Plasma concentrations of brain-derived neurotrophic factor (BDNF; pg/mL), a biomarker of neurogenesis, will be examined from blood samples taken before- and after- the 8-week training or control period. | 8-weeks |
| Skeletal muscle size | Ultrasound based assessments of skeletal muscle size (cm^2) will be obtained before- and after- the 8-week training or control period. | 8-weeks |
| Skeletal muscle strength | Skeletal muscle strength (Newton meters [Nm]) will be determined before- and after- the 8-week training or control period. | 8-weeks |
| TNF-alpha | TNF-alpha concentrations (pg/mL) will be examined from blood samples taken before- and after- the 8-week training or control period. TNF-alpha is a cytokine involved in systemic inflammation. | 8-weeks |
| Interleukin-1 receptor agonist | Interleukin-1 receptor agonist concentrations (pg/mL) will be examined from blood samples taken before- and after- the 8-week training or control period. | 8-weeks |
| Skeletal muscle function | Motor unit behavior will be assessed utilizing surface electromyographic signal decomposition, which will be collected while participants perform submaximal isometric (i.e., static) muscle actions. These signals will be collected before- and after- the 8-week training or control period. To examine motor unit behavior, the relationship between motor unit recruitment threshold versus firing rate will be determined for all detected motor units for an individual subject. |
| Measure | Description | Time Frame |
|---|---|---|
| Health-related quality of life | Health-Related Quality of Life: The RAND 36-item short form survey instrument (SF-36) will be used to assess health-related quality of life (HQROL) before- and after- the 8-week training or control period. This will serve as an overall assessment of each individuals' perception of their health. | 8-weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Fasting glucose concentrations | Fasting blood glucose concentrations (mg/dL) will be determined for each participant before-, during (week 4), and after- the 8-week training or control period. | 8-weeks |
| Fasting lipid concentrations |
Inclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 192 Colvin Recreation Center | Stillwater | Oklahoma | 74074 | United States |
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| 8-weeks |
| Cortisol | Concentrations of salivary cortisol (µg/dL), a stress hormone, will be obtained twice in one day (8 h between samples) before- and after- the 8-week training or control period. | 8-weeks |
| Anxiety |
Participants' levels of anxiety will be assessed using the Zung Self-Rating Anxiety Scale (SAS) before- and after- the 8-week training or control period. |
| 8-weeks |
| Depression | Participants' levels of depression will be measured utilizing the Center for Epidemiologic Studies Depression Scale Revised (CESD-R) before- and after- the 8-week training or control period. | 8-weeks |
| Resiliency | Participants' resiliency will be measured using the Connor-Davidson Resilience Scale before- and after- the 8-week training or control period. | 8-weeks |
| Hope | Participants' levels of hope will be assessed with the 12-item adult hope scale before- and after- the 8-week training or control period. | 8-weeks |
| Monocyte Heterogeneity | The heterogeneity of monocyte populations will be determined from the white blood cells in blood plasma using flow cytometry. The relative number (%) of CD14++CD16- vs. CD14+CD16++ vs. CD14++CD16+ monocytes will be determined for each participant before- and after- the 8-week training or control period. | 8-weeks |
Fasting blood lipid concentrations (mg/dL) will be determined for each participant before-, during (week 4), and after- the 8-week training or control period.
| 8-weeks |
| Fasting choleterol concentrations | Fasting blood cholesterol concentrations (mg/dL) will be determined for each participant before-, during (week 4), and after- the 8-week training or control period. | 8-weeks |
| Self Efficacy | Participants' levels of self-efficacy will be assessed with the General Self-Efficacy Scale before- and after- the 8-week training or control period. | 8-weeks |
| Self Esteem | Participants' levels of self-efficacy will be assessed with the Rosenberg Self-Esteem Scale before- and after- the 8-week training or control period. | 8-weeks |
| Grit | Participants' levels of Grit will be measured using the 12-item Grit scale, which assesses passion and perseverance for achieving long-term goals, before- and after- the 8-week training or control period. | 8-weeks |