Comparison Between OSS and 2L PEG/Asc for Bowel Preparation of Elderly People

Comparative Evaluation of the Efficacy of Oral Sulfate Solution (OSS) and 2L Polyethylene Glycol (PEG) With Ascorbic Acid (Asc) for Bowel Preparation of Elderly People: A Multicenter Prospective Randomized Study

For evaluation of the usefulness of oral sulfate solution (OSS) for bowel preparation of elderly people, investigators compare the efficacy, tolerability and safety between OSS and 2L polyethylene glycol (PEG) with ascorbic acid (Asc).

This study is a multicenter, prospective, randomized parallel arm, investigator initiated trial.

The aim of study is to compare oral sulfate solution (OSS) with 2L polyethylene glycol (PEG) with ascorbic acid (Asc) for bowel preparation in elderly people.

99 participants will be enrolled in each group (198 in total). The primary outcome is the efficacy of bowel preparation. Secondary outcomes are tolerability, satisfaction, and safety.

Inclusion Criteria:

• Colonoscopy examinee aged 65-80
• Examinee agree with informed consent

Exclusion Criteria:

• Cognitive disorder, mental retardation
• Bowel obstruction
• Severe constipation (<3 bowel movements per week with or without regular or intermittent laxatives)
• History of bowel surgery
• Liver cirrhosis or ascites
• Heart failure, cardiac disease (ischemic heart disease or coronary artery disease within the last 6 months)
• Inflammatory bowel disease
• Pregnancy, lactating woman
• Renal impairment or history of impaired renal function
• History of hypersensitivity reaction to bowel preparation