Establishing the Diagnosis Standard and Analysis the Risk Factors of POI in Chinese Women

Establishing the Diagnosis Standard and Analysis the Risk Factors of Premature Ovarian Insufficiency in Chinese Women： Multi-center, Prospective,Observational Study

The study aims to establishing the diagnosis standard of POI and analyzing the risk factors in Chinese women.

Premature ovarian insufficiency (POI) is a clinical syndrome defined by loss of ovarian activity before the age of 40 years. The POI guideline development group of ESHRE recommends the following diagnostic criteria: oligo/amenorrhea for at least 4 months and an elevated follicle stimulating hormone (FSH) level >25 mIU/mL on two occasion >4 weeks apart. But there still no diagnosis standard of POI in Chinese.The study aims to establishing the diagnosis standard of POI and analyzing the risk factors in Chinese women.

Inclusion Criteria:

• Infertility
• The length of menstrual cycle longer than 35 days or shorter than/amenorrhea
• Serum FSH levels ≥10mIU/ml/ serum AMH levels ≤1.0pg/ml/ AFC ≤7, on at least two occasion >4 weeks apart

Exclusion Criteria:

• Polycystic Ovarian Syndrome
• other causes of amenorrhea