Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This laboratory study will employ a multi-session experimental design to examine the behavioral economic demand for marijuana, by studying effect of marijuana administration (High THC) on demand for marijuana, and marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly.
This laboratory study will employ a multi-session experimental design to examine craving for marijuana, the effect of marijuana administration (High THC) on behavioral economic demand for marijuana, and marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly. The relationship between hypothetical and actual demand for marijuana will be examined. We will also investigate relationship between demand for marijuana and indices of marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly to obtain a final sample of 85 with complete data (15% of attrition). Participants will be tested at a baseline session and during two experimental sessions (an ad libitum marijuana smoking session and a marijuana smoking topography session). This study will confirm the utility of the hypothetical marijuana purchase task as a reliable and valid tool for assessing behavioral economic marijuana demand.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High THC dose (6% THC) | Experimental | Smoked marijuana cigarettes (High THC dose [6% THC]) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Smoked marijuana cigarettes: High THC dose (6% THC) | Drug | Smoked marijuana cigarettes (High THC dose [6% THC]) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Validity of the Marijuana Purchase Task (MPT) | The Marijuana Purchase Task will be used to collect data on marijuana demand. Participants indicate how much marijuana they would purchase at varying levels of price (e.g., free - $60). Indices of marijuana demand are derived from the task and used to determine the relative value of marijuana for each participant. Hits purchased on the MPT will correspond with actual number of hits purchased and smoked in the laboratory. Primary outcome is percentage of participants who purchased and smoked exactly what they said they would. | Duration of the experimental session (i.e., 60 minutes) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Marijuana Craving Questionnaire (MCQ) | Subjective marijuana craving was assessed via a 10-item Marijuana Craving Questionnaire. Participants were asked to respond to items according to how they were thinking or feeling "right now," and MCQ items were rated on a 1 = "strongly disagree" to 7 = "strongly agree" scale, with higher scores indicating greater subjective marijuana craving, and summed to yield a total craving score. Total craving score was used in analyses. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Elizabeth Aston, PhD | Brown University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brown University | Providence | Rhode Island | 02903 | United States |
Not provided
Not provided
Not provided
| ID | Title | Description |
|---|---|---|
| FG000 | High THC Dose (6% THC) | Smoked marijuana cigarettes (High THC dose [6% THC]) |
| Title | Milestones | Reasons Not Completed | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
Not provided
Not provided
| ID | Title | Description |
|---|---|---|
| BG000 | High THC Dose (6% THC) | Smoked marijuana cigarettes (High THC dose [6% THC]) Smoked marijuana cigarettes: High THC dose (6% THC): Smoked marijuana cigarettes (High THC dose [6% THC]) |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Validity of the Marijuana Purchase Task (MPT) | The Marijuana Purchase Task will be used to collect data on marijuana demand. Participants indicate how much marijuana they would purchase at varying levels of price (e.g., free - $60). Indices of marijuana demand are derived from the task and used to determine the relative value of marijuana for each participant. Hits purchased on the MPT will correspond with actual number of hits purchased and smoked in the laboratory. Primary outcome is percentage of participants who purchased and smoked exactly what they said they would. | All participants who completed Session 1 (n=101), reported purchasing at least 1 hit from a cannabis joint at their randomly selected price-point on the Marijuana Purchase Task (n=90), and chose to smoke during the Session (n=86) were included in the analysis. Outcome corresponds to percentage of participants who smoked exactly what they said they would. | Posted | Number | percentage of participants | Duration of the experimental session (i.e., 60 minutes) |
|
1 month
Not provided
Not provided
| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | High THC Dose (6% THC) | Smoked marijuana cigarettes (High THC dose [6% THC]) Smoked marijuana cigarettes: High THC dose (6% THC): Smoked marijuana cigarettes (High THC dose [6% THC]) |
Not provided
Not provided
Not provided
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Elizabeth Aston, PhD | Brown University | 401-863-6668 | elizabeth_aston@brown.edu |
Not provided
| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Oct 8, 2020 | Jan 8, 2024 | Prot_SAP_001.pdf |
| ICF | No | No | Yes | Informed Consent Form | Oct 8, 2020 | May 24, 2021 | ICF_000.pdf |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D008385 | Marijuana Smoking |
| ID | Term |
|---|---|
| D000074609 | Marijuana Use |
| D001519 | Behavior |
| D000073847 | Smoking, Non-Tobacco Products |
| D012907 | Smoking |
Not provided
Not provided
| ID | Term |
|---|---|
| D013759 | Dronabinol |
| ID | Term |
|---|---|
| D002186 | Cannabinoids |
| D013729 | Terpenes |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| The MCQ will be administered pre- and post- marijuana smoking during the experimental session, up to 6 hours |
| Marijuana Smoking Topography | Indices of Marijuana Smoking Topography will be obtained during the experimental session. Participants will smoke marijuana through a smoking topography device. The outcome measure is number of puffs. | Marijuana smoking topography indices will be collected during the 1-hour ad libitum marijuana smoking topography experimental session. |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Ethnicity (NIH/OMB) | Count of Participants | Participants |
|
| Race (NIH/OMB) | Count of Participants | Participants |
|
| High THC Dose (6% THC) |
Smoked marijuana cigarettes (High THC dose [6% THC]) Smoked marijuana cigarettes: High THC dose (6% THC): Smoked marijuana cigarettes (High THC dose [6% THC]) |
|
|
|
| Secondary | Change in Marijuana Craving Questionnaire (MCQ) | Subjective marijuana craving was assessed via a 10-item Marijuana Craving Questionnaire. Participants were asked to respond to items according to how they were thinking or feeling "right now," and MCQ items were rated on a 1 = "strongly disagree" to 7 = "strongly agree" scale, with higher scores indicating greater subjective marijuana craving, and summed to yield a total craving score. Total craving score was used in analyses. | All participants who completed Session 1 (n=101), reported purchasing at least 1 hit from a cannabis joint at their randomly selected price-point on the Marijuana Purchase Task (n=90), and chose to smoke during the Session (n=86) were included in the analysis. | Posted | Mean | Standard Deviation | units on the MCQ | The MCQ will be administered pre- and post- marijuana smoking during the experimental session, up to 6 hours |
|
|
|
|
| Secondary | Marijuana Smoking Topography | Indices of Marijuana Smoking Topography will be obtained during the experimental session. Participants will smoke marijuana through a smoking topography device. The outcome measure is number of puffs. | Participants who completed Session 2 with usable smoking topography data. | Posted | Mean | Standard Deviation | puffs | Marijuana smoking topography indices will be collected during the 1-hour ad libitum marijuana smoking topography experimental session. |
|
|
|
|
| 0 |
| 114 |
| 0 |
| 114 |
| 0 |
| 114 |
Not provided
Not provided