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| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2018-00151 | Registry Identifier | CTRP (Clinical Trial Reporting Program) | |
| EAQ162CD | Other Identifier | ECOG-ACRIN Cancer Research Group | |
| ECOG-ACRIN-EAQ162CD | Other Identifier | DCP | |
| ECOG-ACRIN-EAQ162CD | Other Identifier | CTEP | |
| U10CA180820 | U.S. NIH Grant/Contract | View source | |
| UG1CA189828 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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This research trial studies the financial burden in patients with stage I-III colon or rectal cancer who are undergoing treatment. Collecting data from patients about their cost and quality of life may help doctors to better understand the impact of cancer treatment on a patient?s employment and finances.
PRIMARY OBJECTIVES:
I. Evaluate the change in level of self-reported financial burden from baseline (within 60 days of diagnosis) to 12 months after diagnosis of colon or rectal cancer treated with curative-intent.
SECONDARY OBJECTVIES:
I. Evaluate reported access and utilization of financial services (i.e. financial counselor, navigator, social workers) and its association to financial burden in the first 12 months after diagnosis of colon or rectal cancer treated with curative-intent.
II. Evaluate the change in level of self-reported financial burden and employment limitations from baseline (within 60 days of diagnosis) to 3, 6, and 12 months after diagnosis of colon or rectal cancer treated with curative-intent.
III. Evaluate long term outcomes at 24 months after diagnosis including financial burden, employment limitations and adherence to clinical follow-up guidelines.
IV. Evaluate the change of quality-of-life outcome (QoL) from baseline to 12 months and its association with predictors.
V. Evaluate the change in level of self-reported financial burden from baseline to 12 months using alternate measures of financial burden (i.e. impact of cost questions and single item from European Organization for Research and Treatment of Cancer [EORTC] questionnaire [Q]30).
OUTLINE:
Patients complete questionnaires over 20-60 minutes at baseline and at 3, 6, 12, and 24 months after cancer diagnosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Observational (questionnaire) | Patients complete questionnaires over 20-60 minutes at baseline and at 3, 6, 12, and 24 months after cancer diagnosis. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Quality-of-Life Assessment | Other | Ancillary studies |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comprehensive Score for Financial Toxicity (COST) | The Comprehensive Score for Financial Toxicity (COST) COST is an 11-item patient-reported outcome (PRO) of financial hardship that uses a 7-day time window and 5-point Likert response scale (ranging from 0, indicating not at all, to 4, very much). Higher COST scores (range, 0-44) represent better financial well-being. The primary objective is to evaluate the change in the level of self-reported financial burden from baseline (within 60 days of diagnosis) to 12 months from study registration. (12 mo - baseline) | Baseline and 12 months after cancer diagnosis |
| Measure | Description | Time Frame |
|---|---|---|
| Reported Access and Utilization of Financial Services | Will evaluate reported access and utilization of financial services (i.e. financial counselor, navigator, social workers) and its association to financial burden in the first 12 months after diagnosis of colon or rectal cancer treated with curative-intent. Will be assessed by Consumer Based Cancer Care Value Index (CCVI). For the continuous item variable, will conduct the paired t test to examine the difference if the distribution is normal. If not normally distributed, Wilcoxon signed rank test will be used. For the categorical item variable, the paired proportion test (e.g., McNemar test) will be used instead. The association between CCVI and COST measures will be evaluated using the Pearson or Spearman correlation coefficient. |
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Inclusion Criteria:
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Patients from a gastroenterology, surgical oncology, radiation oncology, or medical oncology clinic with newly diagnosed colon or rectal cancer are potential candidates for the study. Subjects must enroll within 60 days of their diagnostic biopsy or curative-intent surgery and prior to any chemotherapy and/or radiation
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| Name | Affiliation | Role |
|---|---|---|
| Sheetal Kircher | ECOG-ACRIN Cancer Research Group | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Anchorage Associates in Radiation Medicine | Anchorage | Alaska | 98508 | United States | ||
| Anchorage Radiation Therapy Center |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39287948 | Derived | Sadigh G, Duan F, An N, Gareen ID, Sicks J, Suga JM, Kehn H, Mehan PT, Bajaj R, Hanson DS, Dalia SM, Acoba JD, Yasar DG, Taylor MA, Park E, Wagner LI, Kircher SM, Carlos RC. Financial Hardship Among Patients With Early-Stage Colorectal Cancer. JAMA Netw Open. 2024 Sep 3;7(9):e2431967. doi: 10.1001/jamanetworkopen.2024.31967. | |
| 38194233 | Derived | Kircher S, Duan F, An N, Gareen IF, Sicks JD, Sadigh G, Suga JM, Kehn H, Mehan PT, Bajaj R, Hanson DS, Dalia SM, Acoba JD, Yasar DG, Park ER, Wagner LI, Carlos RC. Patient-Reported Financial Burden of Treatment for Colon or Rectal Cancer. JAMA Netw Open. 2024 Jan 2;7(1):e2350844. doi: 10.1001/jamanetworkopen.2023.50844. |
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This was a, longitudinal cohort study of financial burden in patients with colon, rectal, or rectosigmoid junction cancer. Measurements of financial burden (COST score) were collected at 5 time points over a 24-month follow-up period. Surveys were completed both by sites, to identify available clinical resources, and by participants, to assess the QoL and cost.
The primary endpoint of this study was the change of the COST score from the baseline measurement to the 12-month follow-up (FU).
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| ID | Title | Description |
|---|---|---|
| FG000 | Observational (Questionnaire) | Patients submitted questionnaires assessing financial burden |
| Title | Milestones | Reasons Not Completed | |||||
|---|---|---|---|---|---|---|---|
| Registration through baseline survey com |
|
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Jun 19, 2019 |
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| Questionnaire Administration | Other | Ancillary studies |
|
| Up to 12 months |
| Change in Level of Self-reported Employment Limitations | Change in level of self-reported employment limitations from baseline to 6, 12 and 24 months after study registration will be assessed by Work Productivity and Activity Impairment Questionnaire for a Specific Health Problem (WPAI:SHP). WPAI outcomes are expressed as impairment percentages, with higher numbers indicating greater impairment and less productivity, i.e., worse outcomes, as follows: Questions:
Scores: Multiply scores by 100 to express in percentages. Percent work time missed due to problem: Q2/(Q2+Q4) Percent impairment while working due to problem: Q5/10 Percent overall work impairment due to problem: Q2/(Q2+Q4)+[(1-(Q2/(Q2+Q4)))x(Q5/10)] Percent activity impairment due to problem: Q6/10 | Baseline, 6, 12, and 24 months after cancer diagnosis |
| Level of Self-reported Employment Limitations (Dichotomized) | Change in level of self-reported employment limitations from baseline to 6, 12 and 24 months after study registration will be assessed by Work Productivity and Activity Impairment Questionnaire for a Specific Health Problem (WPAI:SHP). WPAI outcomes are expressed as impairment percentages, with higher numbers indicating greater impairment and less productivity, i.e., worse outcomes. These outcomes were further dichotomized at 50%, such that Impairment > 50% was considered impaired and Impairment <=50% was not-impaired | Baseline, 6, 12, and 24 months after cancer diagnosis |
| Long Term Outcomes After Diagnosis for Adherence | Will evaluate long term outcomes at 24 months after diagnosis for adherence to clinical follow-up guidelines. Specially, linear (or generalized linear) mixed model will be fit to study the change in the mean response over time. In case the changes in the mean response over time are not linear, the quadratic trends or non-linear trends via spline may be considered in the modeling. Interactions will be evaluated as well. | At 24 months |
| Long Term Outcomes After Diagnosis for Financial Burden | Will evaluate long term outcomes at 24 months after diagnosis for financial burden. Specially, linear (or generalized linear) mixed model will be fit to study the change in the mean response over time and also the effects of cancer type, stage, treatment plan and demographics, etc. on financial burden. In case the changes in the mean response over time are not linear, the quadratic trends or non-linear trends via spline may be considered in the modeling. Interactions will be evaluated as well. | At 24 months |
| Long Term Outcomes After Diagnosis for Employment Limitations | Will evaluate long term outcomes at 24 months after diagnosis for employment limitations. Specially, linear (or generalized linear) mixed model will be fit to study the change in the mean response over time. In case the changes in the mean response over time are not linear, the quadratic trends or non-linear trends via spline may be considered in the modeling. Interactions will be evaluated as well. | At 24 months |
| Change of Quality-of-life (QoL) Outcome | Will evaluate the change of QoL from baseline to 12 months and its association with predictors. Will be evaluated by Functional Assessment of Cancer Therapy-General. | Baseline up to 12 months |
| Changes Self-reported Financial Burden Between Baseline and 12 Month [EORTC] | Financial Burden was evaluated using a single item from European Organization for Research and Treatment of Cancer Questionnaire 30 [EORT30]) with responses for both baseline and 12 months EORTC30 question: Has your physical condition or medical treatment caused you financial difficulties?
| Baseline and12 months |
| Anchorage |
| Alaska |
| 99504 |
| United States |
| Alaska Breast Care and Surgery LLC | Anchorage | Alaska | 99508 | United States |
| Alaska Oncology and Hematology LLC | Anchorage | Alaska | 99508 | United States |
| Alaska Women's Cancer Care | Anchorage | Alaska | 99508 | United States |
| Anchorage Oncology Centre | Anchorage | Alaska | 99508 | United States |
| Katmai Oncology Group | Anchorage | Alaska | 99508 | United States |
| Providence Alaska Medical Center | Anchorage | Alaska | 99508 | United States |
| Fairbanks Memorial Hospital | Fairbanks | Alaska | 99701 | United States |
| Kingman Regional Medical Center | Kingman | Arizona | 86401 | United States |
| Mercy Hospital Fort Smith | Fort Smith | Arkansas | 72903 | United States |
| CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas | 71913 | United States |
| Kaiser Permanente-Anaheim | Anaheim | California | 92806 | United States |
| Kaiser Permanente-Deer Valley Medical Center | Antioch | California | 94531 | United States |
| PCR Oncology | Arroyo Grande | California | 93420 | United States |
| Kaiser Permanente-Baldwin Park | Baldwin Park | California | 91706 | United States |
| Kaiser Permanente-Bellflower | Bellflower | California | 90706 | United States |
| Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | 91505 | United States |
| Epic Care-Dublin | Dublin | California | 94568 | United States |
| Kaiser Permanente Dublin | Dublin | California | 94568 | United States |
| Bay Area Breast Surgeons Inc | Emeryville | California | 94608 | United States |
| Epic Care Partners in Cancer Care | Emeryville | California | 94608 | United States |
| Kaiser Permanente-Fontana | Fontana | California | 92335 | United States |
| Kaiser Permanente-Fremont | Fremont | California | 94538 | United States |
| Fresno Cancer Center | Fresno | California | 93720 | United States |
| Kaiser Permanente-Fresno | Fresno | California | 93720 | United States |
| Kaiser Permanente - Harbor City | Harbor City | California | 90710 | United States |
| Kaiser Permanente-Irvine | Irvine | California | 92618 | United States |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | United States |
| Kaiser Permanente-Cadillac | Los Angeles | California | 90034 | United States |
| Contra Costa Regional Medical Center | Martinez | California | 94553-3156 | United States |
| Kaiser Permanente-Modesto | Modesto | California | 95356 | United States |
| Alta Bates Summit Medical Center - Summit Campus | Oakland | California | 94609 | United States |
| Bay Area Tumor Institute | Oakland | California | 94609 | United States |
| Kaiser Permanente Oakland-Broadway | Oakland | California | 94611 | United States |
| Kaiser Permanente-Oakland | Oakland | California | 94611 | United States |
| Kaiser Permanente-Ontario | Ontario | California | 91761 | United States |
| Kaiser Permanente - Panorama City | Panorama City | California | 91402 | United States |
| Kaiser Permanente-Rancho Cordova Cancer Center | Rancho Cordova | California | 95670 | United States |
| Kaiser Permanente-Redwood City | Redwood City | California | 94063 | United States |
| Kaiser Permanente-Richmond | Richmond | California | 94801 | United States |
| Kaiser Permanente-Riverside | Riverside | California | 92505 | United States |
| Rohnert Park Cancer Center | Rohnert Park | California | 94928 | United States |
| Kaiser Permanente-Roseville | Roseville | California | 95661 | United States |
| The Permanente Medical Group-Roseville Radiation Oncology | Roseville | California | 95678 | United States |
| Kaiser Permanente Downtown Commons | Sacramento | California | 95814 | United States |
| Kaiser Permanente-South Sacramento | Sacramento | California | 95823 | United States |
| South Sacramento Cancer Center | Sacramento | California | 95823 | United States |
| Kaiser Permanente - Sacramento | Sacramento | California | 95825 | United States |
| Kaiser Permanente-San Diego Mission | San Diego | California | 92108 | United States |
| Kaiser Permanente-San Diego Zion | San Diego | California | 92120 | United States |
| Kaiser Permanente-San Francisco | San Francisco | California | 94115 | United States |
| Kaiser Permanente-Santa Teresa-San Jose | San Jose | California | 95119 | United States |
| Kaiser Permanente San Leandro | San Leandro | California | 94577 | United States |
| Kaiser Permanente-San Marcos | San Marcos | California | 92078 | United States |
| Kaiser Permanente-San Rafael | San Rafael | California | 94903 | United States |
| Kaiser San Rafael-Gallinas | San Rafael | California | 94903 | United States |
| Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | 95051 | United States |
| Kaiser Permanente-Santa Rosa | Santa Rosa | California | 95403 | United States |
| Kaiser Permanente Cancer Treatment Center | South San Francisco | California | 94080 | United States |
| Kaiser Permanente-South San Francisco | South San Francisco | California | 94080 | United States |
| Kaiser Permanente-Stockton | Stockton | California | 95210 | United States |
| Kaiser Permanente Medical Center-Vacaville | Vacaville | California | 95688 | United States |
| Kaiser Permanente-Vallejo | Vallejo | California | 94589 | United States |
| Kaiser Permanente-Walnut Creek | Walnut Creek | California | 94596 | United States |
| Epic Care Cyberknife Center | Walnut Creek | California | 94597 | United States |
| Kaiser Permanente-Woodland Hills | Woodland Hills | California | 91367 | United States |
| Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado | 80012 | United States |
| The Medical Center of Aurora | Aurora | Colorado | 80012 | United States |
| Boulder Community Hospital | Boulder | Colorado | 80301 | United States |
| Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | 80304 | United States |
| Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | 80907 | United States |
| Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado | 80907 | United States |
| Cancer Center of Colorado at Sloan's Lake | Denver | Colorado | 80204 | United States |
| Denver Health Medical Center | Denver | Colorado | 80204 | United States |
| Kaiser Permanente-Franklin | Denver | Colorado | 80205 | United States |
| National Jewish Health-Main Campus | Denver | Colorado | 80206 | United States |
| The Women's Imaging Center | Denver | Colorado | 80209 | United States |
| Porter Adventist Hospital | Denver | Colorado | 80210 | United States |
| Colorado Blood Cancer Institute | Denver | Colorado | 80218 | United States |
| Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | 80218 | United States |
| Rocky Mountain Cancer Centers-Midtown | Denver | Colorado | 80218 | United States |
| SCL Health Saint Joseph Hospital | Denver | Colorado | 80218 | United States |
| Rocky Mountain Cancer Centers-Rose | Denver | Colorado | 80220 | United States |
| Rose Medical Center | Denver | Colorado | 80220 | United States |
| Western Surgical Care | Denver | Colorado | 80220 | United States |
| Mercy Medical Center | Durango | Colorado | 81301 | United States |
| Southwest Oncology PC | Durango | Colorado | 81301 | United States |
| Mountain Blue Cancer Care Center - Swedish | Englewood | Colorado | 80113 | United States |
| Swedish Medical Center | Englewood | Colorado | 80113 | United States |
| Mountain Blue Cancer Care Center | Golden | Colorado | 80401 | United States |
| National Jewish Health-Western Hematology Oncology | Golden | Colorado | 80401 | United States |
| Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | 81501 | United States |
| North Colorado Medical Center | Greeley | Colorado | 80631 | United States |
| Good Samaritan Medical Center | Lafayette | Colorado | 80026 | United States |
| Kaiser Permanente-Rock Creek | Lafayette | Colorado | 80026 | United States |
| Rocky Mountain Cancer Centers-Lakewood | Lakewood | Colorado | 80228 | United States |
| Saint Anthony Hospital | Lakewood | Colorado | 80228 | United States |
| Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado | 80120 | United States |
| Littleton Adventist Hospital | Littleton | Colorado | 80122 | United States |
| Kaiser Permanente-Lone Tree | Lone Tree | Colorado | 80124 | United States |
| Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado | 80124 | United States |
| Sky Ridge Medical Center | Lone Tree | Colorado | 80124 | United States |
| Longmont United Hospital | Longmont | Colorado | 80501 | United States |
| Rocky Mountain Cancer Centers-Longmont | Longmont | Colorado | 80501 | United States |
| McKee Medical Center | Loveland | Colorado | 80539 | United States |
| Parker Adventist Hospital | Parker | Colorado | 80138 | United States |
| Rocky Mountain Cancer Centers-Parker | Parker | Colorado | 80138 | United States |
| Saint Mary Corwin Medical Center | Pueblo | Colorado | 81004 | United States |
| Rocky Mountain Cancer Centers - Pueblo | Pueblo | Colorado | 81008 | United States |
| National Jewish Health-Northern Hematology Oncology | Thornton | Colorado | 80260 | United States |
| Rocky Mountain Cancer Centers-Thornton | Thornton | Colorado | 80260 | United States |
| SCL Health Lutheran Medical Center | Wheat Ridge | Colorado | 80033 | United States |
| Beebe Medical Center | Lewes | Delaware | 19958 | United States |
| Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | 19713 | United States |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | United States |
| Medical Oncology Hematology Consultants PA | Newark | Delaware | 19713 | United States |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | United States |
| Beebe Health Campus | Rehoboth Beach | Delaware | 19971 | United States |
| Nanticoke Memorial Hospital | Seaford | Delaware | 19973 | United States |
| Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware | 19801 | United States |
| Holy Cross Hospital | Fort Lauderdale | Florida | 33308 | United States |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | 31405 | United States |
| Low Country Cancer Care Associates PC | Savannah | Georgia | 31405 | United States |
| Summit Cancer Care-Candler | Savannah | Georgia | 31405 | United States |
| Hawaii Cancer Care Inc-POB II | Honolulu | Hawaii | 96813 | United States |
| Island Urology | Honolulu | Hawaii | 96813 | United States |
| Queen's Cancer Cenrer - POB I | Honolulu | Hawaii | 96813 | United States |
| Queen's Medical Center | Honolulu | Hawaii | 96813 | United States |
| Straub Clinic and Hospital | Honolulu | Hawaii | 96813 | United States |
| University of Hawaii Cancer Center | Honolulu | Hawaii | 96813 | United States |
| Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii | 96817 | United States |
| Kuakini Medical Center | Honolulu | Hawaii | 96817 | United States |
| Queen's Cancer Center - Kuakini | Honolulu | Hawaii | 96817 | United States |
| The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | 96817 | United States |
| Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii | 96819 | United States |
| Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | 96826 | United States |
| Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii | 96766 | United States |
| Hawaii Cancer Care - Savio | ‘Aiea | Hawaii | 96701 | United States |
| Pali Momi Medical Center | ‘Aiea | Hawaii | 96701 | United States |
| Queen's Cancer Center - Pearlridge | ‘Aiea | Hawaii | 96701 | United States |
| The Cancer Center of Hawaii-Pali Momi | ‘Aiea | Hawaii | 96701 | United States |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | United States |
| Saint Luke's Mountain States Tumor Institute | Boise | Idaho | 83712 | United States |
| Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | 83605 | United States |
| Kootenai Medical Center | Coeur d'Alene | Idaho | 83814 | United States |
| Walter Knox Memorial Hospital | Emmett | Idaho | 83617 | United States |
| Saint Luke's Mountain States Tumor Institute - Fruitland | Fruitland | Idaho | 83619 | United States |
| Idaho Urologic Institute-Meridian | Meridian | Idaho | 83642 | United States |
| Saint Luke's Mountain States Tumor Institute - Meridian | Meridian | Idaho | 83642 | United States |
| Saint Alphonsus Medical Center-Nampa | Nampa | Idaho | 83686 | United States |
| Saint Luke's Mountain States Tumor Institute - Nampa | Nampa | Idaho | 83686 | United States |
| Kootenai Cancer Center | Post Falls | Idaho | 83854 | United States |
| Kootenai Cancer Clinic | Sandpoint | Idaho | 83864 | United States |
| Saint Luke's Mountain States Tumor Institute-Twin Falls | Twin Falls | Idaho | 83301 | United States |
| Rush - Copley Medical Center | Aurora | Illinois | 60504 | United States |
| Illinois CancerCare-Bloomington | Bloomington | Illinois | 61704 | United States |
| Illinois CancerCare-Canton | Canton | Illinois | 61520 | United States |
| Memorial Hospital of Carbondale | Carbondale | Illinois | 62902 | United States |
| SIH Cancer Institute | Carterville | Illinois | 62918 | United States |
| Illinois CancerCare-Carthage | Carthage | Illinois | 62321 | United States |
| Centralia Oncology Clinic | Centralia | Illinois | 62801 | United States |
| John H Stroger Jr Hospital of Cook County | Chicago | Illinois | 60612 | United States |
| Carle on Vermilion | Danville | Illinois | 61832 | United States |
| Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | 62526 | United States |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | United States |
| Illinois CancerCare-Dixon | Dixon | Illinois | 61021 | United States |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | United States |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | United States |
| Illinois CancerCare-Eureka | Eureka | Illinois | 61530 | United States |
| Illinois CancerCare-Galesburg | Galesburg | Illinois | 61401 | United States |
| Western Illinois Cancer Treatment Center | Galesburg | Illinois | 61401 | United States |
| Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | 61443 | United States |
| Illinois CancerCare-Macomb | Macomb | Illinois | 61455 | United States |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | United States |
| Trinity Medical Center | Moline | Illinois | 61265 | United States |
| Good Samaritan Regional Health Center | Mount Vernon | Illinois | 62864 | United States |
| Cancer Care Center of O'Fallon | O'Fallon | Illinois | 62269 | United States |
| Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | 61350 | United States |
| Illinois CancerCare-Pekin | Pekin | Illinois | 61554 | United States |
| Illinois CancerCare-Peoria | Peoria | Illinois | 61615 | United States |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | United States |
| Illinois CancerCare-Peru | Peru | Illinois | 61354 | United States |
| Valley Radiation Oncology | Peru | Illinois | 61354 | United States |
| Illinois CancerCare-Princeton | Princeton | Illinois | 61356 | United States |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | United States |
| Springfield Clinic | Springfield | Illinois | 62702 | United States |
| Memorial Medical Center | Springfield | Illinois | 62781 | United States |
| Southwest Illinois Health Services LLP | Swansea | Illinois | 62226 | United States |
| Carle Cancer Center | Urbana | Illinois | 61801 | United States |
| The Carle Foundation Hospital | Urbana | Illinois | 61801 | United States |
| Rush-Copley Healthcare Center | Yorkville | Illinois | 60560 | United States |
| Reid Health | Richmond | Indiana | 47374 | United States |
| Mercy Hospital | Cedar Rapids | Iowa | 52403 | United States |
| Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa | 52403 | United States |
| Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | 50325 | United States |
| Mercy Cancer Center-West Lakes | Clive | Iowa | 50325 | United States |
| Alegent Health Mercy Hospital | Council Bluffs | Iowa | 51503 | United States |
| Greater Regional Medical Center | Creston | Iowa | 50801 | United States |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | United States |
| Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | 50309 | United States |
| Broadlawns Medical Center | Des Moines | Iowa | 50314 | United States |
| Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | 50314 | United States |
| Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | United States |
| Iowa Lutheran Hospital | Des Moines | Iowa | 50316 | United States |
| JCHC McCreery Cancer Center | Fairfield | Iowa | 52556 | United States |
| Trinity Regional Medical Center | Fort Dodge | Iowa | 50501 | United States |
| Ottumwa Regional Health Center | Ottumwa | Iowa | 52501 | United States |
| Methodist West Hospital | West Des Moines | Iowa | 50266-7700 | United States |
| Mercy Medical Center-West Lakes | West Des Moines | Iowa | 50266 | United States |
| Central Care Cancer Center - Garden City | Garden City | Kansas | 67846 | United States |
| Central Care Cancer Center - Great Bend | Great Bend | Kansas | 67530 | United States |
| Lawrence Memorial Hospital | Lawrence | Kansas | 66044 | United States |
| Kansas Institute of Medicine Cancer and Blood Center | Lenexa | Kansas | 66219 | United States |
| Minimally Invasive Surgery Hospital | Lenexa | Kansas | 66219 | United States |
| Menorah Medical Center | Overland Park | Kansas | 66209 | United States |
| Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | 67208 | United States |
| Cancer Center of Kansas - Wichita | Wichita | Kansas | 67214 | United States |
| Flaget Memorial Hospital | Bardstown | Kentucky | 40004 | United States |
| Commonwealth Cancer Center-Corbin | Corbin | Kentucky | 40701 | United States |
| Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky | 40504 | United States |
| Saint Joseph Hospital East | Lexington | Kentucky | 40509 | United States |
| Saint Joseph London | London | Kentucky | 40741 | United States |
| Jewish Hospital | Louisville | Kentucky | 40202 | United States |
| Saints Mary and Elizabeth Hospital | Louisville | Kentucky | 40215 | United States |
| Jewish Hospital Medical Center Northeast | Louisville | Kentucky | 40245 | United States |
| Jewish Hospital Medical Center South | Shepherdsville | Kentucky | 40165 | United States |
| LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana | 70805 | United States |
| Louisiana Hematology Oncology Associates LLC | Baton Rouge | Louisiana | 70809 | United States |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | United States |
| Ochsner Health Center-Summa | Baton Rouge | Louisiana | 70809 | United States |
| Our Lady of the Lake Physicians Group - Medical Oncology | Baton Rouge | Louisiana | 70809 | United States |
| Medical Center of Baton Rouge | Baton Rouge | Louisiana | 70816 | United States |
| Mary Bird Perkins Cancer Center - Covington | Covington | Louisiana | 70433 | United States |
| Northshore Oncology Associates-Covington | Covington | Louisiana | 70433 | United States |
| Mary Bird Perkins Cancer Center - Houma | Houma | Louisiana | 70360 | United States |
| Oncology Center of The South Incorporated | Houma | Louisiana | 70360 | United States |
| Terrebonne General Medical Center | Houma | Louisiana | 70360 | United States |
| Ochsner Medical Center Kenner | Kenner | Louisiana | 70065 | United States |
| Ochsner Medical Center Jefferson | New Orleans | Louisiana | 70121 | United States |
| Mercy Medical Center | Springfield | Massachusetts | 01104 | United States |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48106 | United States |
| Bronson Battle Creek | Battle Creek | Michigan | 49017 | United States |
| IHA Hematology Oncology Consultants-Brighton | Brighton | Michigan | 48114 | United States |
| Saint Joseph Mercy Brighton | Brighton | Michigan | 48114 | United States |
| IHA Hematology Oncology Consultants-Canton | Canton | Michigan | 48188 | United States |
| Saint Joseph Mercy Canton | Canton | Michigan | 48188 | United States |
| Caro Cancer Center | Caro | Michigan | 48723 | United States |
| IHA Hematology Oncology Consultants-Chelsea | Chelsea | Michigan | 48118 | United States |
| Saint Joseph Mercy Chelsea | Chelsea | Michigan | 48118 | United States |
| Hematology Oncology Consultants-Clarkston | Clarkston | Michigan | 48346 | United States |
| Newland Medical Associates-Clarkston | Clarkston | Michigan | 48346 | United States |
| Beaumont Hospital - Dearborn | Dearborn | Michigan | 48124 | United States |
| Ascension Saint John Hospital | Detroit | Michigan | 48236 | United States |
| Great Lakes Cancer Management Specialists-Doctors Park | East China | Michigan | 48054 | United States |
| Green Bay Oncology - Escanaba | Escanaba | Michigan | 49829 | United States |
| Beaumont Hospital - Farmington Hills | Farmington Hills | Michigan | 48336 | United States |
| Genesee Cancer and Blood Disease Treatment Center | Flint | Michigan | 48503 | United States |
| Genesee Hematology Oncology PC | Flint | Michigan | 48503 | United States |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | United States |
| Hurley Medical Center | Flint | Michigan | 48503 | United States |
| Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan | 49503 | United States |
| Mercy Health Saint Mary's | Grand Rapids | Michigan | 49503 | United States |
| Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | 49503 | United States |
| William Beaumont Hospital-Grosse Point | Grosse Pointe | Michigan | 48230 | United States |
| Academic Hematology Oncology Specialists | Grosse Pointe Woods | Michigan | 48236 | United States |
| Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods | Michigan | 48236 | United States |
| Michigan Breast Specialists-Grosse Pointe Woods | Grosse Pointe Woods | Michigan | 48236 | United States |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | United States |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | United States |
| Borgess Medical Center | Kalamazoo | Michigan | 49048 | United States |
| Sparrow Hospital | Lansing | Michigan | 48912 | United States |
| Hope Cancer Clinic | Livonia | Michigan | 48154 | United States |
| Saint Mary Mercy Hospital | Livonia | Michigan | 48154 | United States |
| Great Lakes Cancer Management Specialists-Macomb Medical Campus | Macomb | Michigan | 48044 | United States |
| Michigan Breast Specialists-Macomb Township | Macomb | Michigan | 48044 | United States |
| Saint Mary's Oncology/Hematology Associates of Marlette | Marlette | Michigan | 48453 | United States |
| Mercy Health Mercy Campus | Muskegon | Michigan | 49444 | United States |
| Lakeland Hospital Niles | Niles | Michigan | 49120 | United States |
| Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan | 49444 | United States |
| 21st Century Oncology-Pontiac | Pontiac | Michigan | 48341 | United States |
| Hope Cancer Center | Pontiac | Michigan | 48341 | United States |
| Newland Medical Associates-Pontiac | Pontiac | Michigan | 48341 | United States |
| Saint Joseph Mercy Oakland | Pontiac | Michigan | 48341 | United States |
| Huron Medical Center PC | Port Huron | Michigan | 48060 | United States |
| Lake Huron Medical Center | Port Huron | Michigan | 48060 | United States |
| Spectrum Health Reed City Hospital | Reed City | Michigan | 49677 | United States |
| Great Lakes Cancer Management Specialists-Rochester Hills | Rochester Hills | Michigan | 48309 | United States |
| Michigan Cancer Specialists | Roseville | Michigan | 48066 | United States |
| Oakland Colon and Rectal Association | Royal Oak | Michigan | 48067 | United States |
| Cancer Care Associates PC | Royal Oak | Michigan | 48073 | United States |
| Comprehensive Medical Center PLLC | Royal Oak | Michigan | 48073 | United States |
| Hematology Oncology Consultants PC | Royal Oak | Michigan | 48073 | United States |
| Oakland Medical Group | Royal Oak | Michigan | 48073 | United States |
| William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | 48073 | United States |
| Ascension Saint Mary's Hospital | Saginaw | Michigan | 48601 | United States |
| Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan | 48604 | United States |
| Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | 49085 | United States |
| Marie Yeager Cancer Center | Saint Joseph | Michigan | 49085 | United States |
| Bhadresh Nayak MD PC-Sterling Heights | Sterling Heights | Michigan | 48312 | United States |
| Premier Hematology Oncology Care | Sterling Heights | Michigan | 48312 | United States |
| Mitchell Folbe MD PC | Sterling Heights | Michigan | 48314 | United States |
| Ascension Saint Joseph Hospital | Tawas City | Michigan | 48764 | United States |
| Munson Medical Center | Traverse City | Michigan | 49684 | United States |
| Michigan Institute of Urology-Town Center | Troy | Michigan | 48084 | United States |
| Claudia BR Herke MD PC | Troy | Michigan | 48085 | United States |
| William Beaumont Hospital - Troy | Troy | Michigan | 48085 | United States |
| Hematology Oncology Consultants PC-Troy | Troy | Michigan | 48098 | United States |
| Advanced Breast Care Center PLLC | Warren | Michigan | 48088 | United States |
| Great Lakes Cancer Management Specialists-Macomb Professional Building | Warren | Michigan | 48093 | United States |
| Macomb Hematology Oncology PC | Warren | Michigan | 48093 | United States |
| Michigan Breast Specialists-Warren | Warren | Michigan | 48093 | United States |
| Saint John Macomb-Oakland Hospital | Warren | Michigan | 48093 | United States |
| Saint Mary's Oncology/Hematology Associates of West Branch | West Branch | Michigan | 48661 | United States |
| Metro Health Hospital | Wyoming | Michigan | 49519 | United States |
| Huron Gastroenterology PC | Ypsilanti | Michigan | 48106 | United States |
| IHA Hematology Oncology Consultants-Ann Arbor | Ypsilanti | Michigan | 48197 | United States |
| Riverwood Healthcare Center | Aitkin | Minnesota | 56431 | United States |
| Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | 56601 | United States |
| Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | 56401 | United States |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | United States |
| Cambridge Medical Center | Cambridge | Minnesota | 55008 | United States |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | United States |
| Essentia Health - Deer River Clinic | Deer River | Minnesota | 56636 | United States |
| Essentia Health Saint Mary's - Detroit Lakes Clinic | Detroit Lakes | Minnesota | 56501 | United States |
| Essentia Health Cancer Center | Duluth | Minnesota | 55805 | United States |
| Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | 55805 | United States |
| Miller-Dwan Hospital | Duluth | Minnesota | 55805 | United States |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | United States |
| Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota | 56537 | United States |
| Essentia Health - Fosston | Fosston | Minnesota | 56542 | United States |
| Unity Hospital | Fridley | Minnesota | 55432 | United States |
| Essentia Health Hibbing Clinic | Hibbing | Minnesota | 55746 | United States |
| Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota | 55369 | United States |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | 55109 | United States |
| Saint John's Hospital - Healtheast | Maplewood | Minnesota | 55109 | United States |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | United States |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | United States |
| Health Partners Inc | Minneapolis | Minnesota | 55454 | United States |
| Monticello Cancer Center | Monticello | Minnesota | 55362 | United States |
| New Ulm Medical Center | New Ulm | Minnesota | 56073 | United States |
| Essentia Health - Park Rapids | Park Rapids | Minnesota | 56470 | United States |
| Fairview Northland Medical Center | Princeton | Minnesota | 55371 | United States |
| North Memorial Medical Health Center | Robbinsdale | Minnesota | 55422 | United States |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | United States |
| Regions Hospital | Saint Paul | Minnesota | 55101 | United States |
| United Hospital | Saint Paul | Minnesota | 55102 | United States |
| Essentia Health Sandstone | Sandstone | Minnesota | 55072 | United States |
| Saint Francis Regional Medical Center | Shakopee | Minnesota | 55379 | United States |
| Lakeview Hospital | Stillwater | Minnesota | 55082 | United States |
| Sanford Thief River Falls Medical Center | Thief River Falls | Minnesota | 56701 | United States |
| Essentia Health Virginia Clinic | Virginia | Minnesota | 55792 | United States |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | United States |
| Rice Memorial Hospital | Willmar | Minnesota | 56201 | United States |
| Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | 55125 | United States |
| Sanford Cancer Center Worthington | Worthington | Minnesota | 56187 | United States |
| Fairview Lakes Medical Center | Wyoming | Minnesota | 55092 | United States |
| Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri | 63011 | United States |
| Central Care Cancer Center - Bolivar | Bolivar | Missouri | 65613 | United States |
| Parkland Health Center-Bonne Terre | Bonne Terre | Missouri | 63628 | United States |
| Cox Cancer Center Branson | Branson | Missouri | 65616 | United States |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | United States |
| Southeast Cancer Center | Cape Girardeau | Missouri | 63703 | United States |
| Parkland Health Center - Farmington | Farmington | Missouri | 63640 | United States |
| Centerpoint Medical Center LLC | Independence | Missouri | 64057 | United States |
| Capital Region Southwest Campus | Jefferson City | Missouri | 65109 | United States |
| Freeman Health System | Joplin | Missouri | 64804 | United States |
| Mercy Hospital Joplin | Joplin | Missouri | 64804 | United States |
| Research Medical Center | Kansas City | Missouri | 64132 | United States |
| Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | 65401 | United States |
| Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | 65401 | United States |
| Heartland Regional Medical Center | Saint Joseph | Missouri | 64506 | United States |
| Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | 63670 | United States |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | United States |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | United States |
| Saint Louis Cancer and Breast Institute-South City | St Louis | Missouri | 63109 | United States |
| Mercy Hospital South | St Louis | Missouri | 63128 | United States |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | United States |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | United States |
| Missouri Baptist Sullivan Hospital | Sullivan | Missouri | 63080 | United States |
| Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | 63127 | United States |
| Mercy Hospital Washington | Washington | Missouri | 63090 | United States |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | United States |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | United States |
| Saint Vincent Healthcare | Billings | Montana | 59101 | United States |
| Saint Vincent Frontier Cancer Center | Billings | Montana | 59102 | United States |
| Bozeman Deaconess Hospital | Bozeman | Montana | 59715 | United States |
| Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | 59701 | United States |
| Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | 59405 | United States |
| Great Falls Clinic | Great Falls | Montana | 59405 | United States |
| Saint Peter's Community Hospital | Helena | Montana | 59601 | United States |
| Kalispell Regional Medical Center | Kalispell | Montana | 59901 | United States |
| Saint Patrick Hospital - Community Hospital | Missoula | Montana | 59802 | United States |
| Community Medical Hospital | Missoula | Montana | 59804 | United States |
| CHI Health Saint Francis | Grand Island | Nebraska | 68803 | United States |
| Heartland Hematology and Oncology | Kearney | Nebraska | 68845 | United States |
| CHI Health Good Samaritan | Kearney | Nebraska | 68847 | United States |
| Saint Elizabeth Regional Medical Center | Lincoln | Nebraska | 68510 | United States |
| Alegent Health Immanuel Medical Center | Omaha | Nebraska | 68122 | United States |
| Hematology and Oncology Consultants PC | Omaha | Nebraska | 68122 | United States |
| Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | 68124 | United States |
| Alegent Health Lakeside Hospital | Omaha | Nebraska | 68130 | United States |
| Creighton University Medical Center | Omaha | Nebraska | 68131 | United States |
| Midlands Community Hospital | Papillion | Nebraska | 68046 | United States |
| Carson Tahoe Regional Medical Center | Carson City | Nevada | 89703 | United States |
| Cancer and Blood Specialists-Henderson | Henderson | Nevada | 89052 | United States |
| Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada | 89052 | United States |
| Comprehensive Cancer Centers of Nevada-Horizon Ridge | Henderson | Nevada | 89052 | United States |
| Las Vegas Cancer Center-Henderson | Henderson | Nevada | 89052 | United States |
| OptumCare Cancer Care at Seven Hills | Henderson | Nevada | 89052 | United States |
| 21st Century Oncology-Henderson | Henderson | Nevada | 89074 | United States |
| Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada | 89074 | United States |
| Las Vegas Urology - Green Valley | Henderson | Nevada | 89074 | United States |
| Las Vegas Urology - Pebble | Henderson | Nevada | 89074 | United States |
| Urology Specialists of Nevada - Green Valley | Henderson | Nevada | 89074 | United States |
| Las Vegas Urology - Pecos | Las Vegas | Nevada | 89074 | United States |
| Desert West Surgery | Las Vegas | Nevada | 89102 | United States |
| OptumCare Cancer Care at Oakey | Las Vegas | Nevada | 89102 | United States |
| University Medical Center of Southern Nevada | Las Vegas | Nevada | 89102 | United States |
| Hope Cancer Care of Nevada | Las Vegas | Nevada | 89103 | United States |
| Cancer and Blood Specialists-Shadow | Las Vegas | Nevada | 89106 | United States |
| Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | 89106 | United States |
| Urology Specialists of Nevada - Central | Las Vegas | Nevada | 89106 | United States |
| 21st Century Oncology | Las Vegas | Nevada | 89109 | United States |
| HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway | Las Vegas | Nevada | 89109 | United States |
| Sunrise Hospital and Medical Center | Las Vegas | Nevada | 89109 | United States |
| HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada | 89113 | United States |
| Las Vegas Prostate Cancer Center | Las Vegas | Nevada | 89113 | United States |
| Las Vegas Urology - Sunset | Las Vegas | Nevada | 89113 | United States |
| Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada | 89119 | United States |
| Cancer Therapy and Integrative Medicine | Las Vegas | Nevada | 89121 | United States |
| 21st Century Oncology-Vegas Tenaya | Las Vegas | Nevada | 89128 | United States |
| Ann M Wierman MD LTD | Las Vegas | Nevada | 89128 | United States |
| Cancer and Blood Specialists-Tenaya | Las Vegas | Nevada | 89128 | United States |
| Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada | 89128 | United States |
| HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada | 89128 | United States |
| Las Vegas Urology - Cathedral Rock | Las Vegas | Nevada | 89128 | United States |
| Las Vegas Urology - Smoke Ranch | Las Vegas | Nevada | 89128 | United States |
| OptumCare Cancer Care at MountainView | Las Vegas | Nevada | 89128 | United States |
| Urology Specialists of Nevada - Northwest | Las Vegas | Nevada | 89128 | United States |
| Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada | 89135 | United States |
| Comprehensive Cancer Centers of Nevada - Town Center | Las Vegas | Nevada | 89144 | United States |
| Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada | 89144 | United States |
| Summerlin Hospital Medical Center | Las Vegas | Nevada | 89144 | United States |
| Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada | 89148-2405 | United States |
| 21st Century Oncology-Fort Apache | Las Vegas | Nevada | 89148 | United States |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89148 | United States |
| OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | 89148 | United States |
| Urology Specialists of Nevada - Southwest | Las Vegas | Nevada | 89148 | United States |
| HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada | 89149 | United States |
| Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | 89169 | United States |
| University Cancer Center | Las Vegas | Nevada | 89169 | United States |
| Hope Cancer Care of Nevada-Pahrump | Pahrump | Nevada | 89048 | United States |
| Renown Regional Medical Center | Reno | Nevada | 89502 | United States |
| Saint Mary's Regional Medical Center | Reno | Nevada | 89503 | United States |
| Radiation Oncology Associates | Reno | Nevada | 89509 | United States |
| AtlantiCare Health Park-Cape May Court House | Cape May Court House | New Jersey | 08210 | United States |
| AtlantiCare Surgery Center | Egg Harbor | New Jersey | 08234 | United States |
| Hunterdon Medical Center | Flemington | New Jersey | 08822 | United States |
| Morristown Medical Center | Morristown | New Jersey | 07960 | United States |
| Newton Medical Center | Newton | New Jersey | 07860 | United States |
| Overlook Hospital | Summit | New Jersey | 07902 | United States |
| Montefiore Medical Center-Einstein Campus | The Bronx | New York | 10461 | United States |
| Montefiore Medical Center-Weiler Hospital | The Bronx | New York | 10461 | United States |
| Montefiore Medical Center - Moses Campus | The Bronx | New York | 10467 | United States |
| Randolph Hospital | Asheboro | North Carolina | 27203 | United States |
| Mission Hospital | Asheville | North Carolina | 28801 | United States |
| AdventHealth Infusion Center Asheville | Asheville | North Carolina | 28803 | United States |
| Cone Health Cancer Center at Alamance Regional | Burlington | North Carolina | 27215 | United States |
| Waverly Hematology Oncology | Cary | North Carolina | 27518 | United States |
| Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina | 28328 | United States |
| AdventHealth Infusion Center Haywood | Clyde | North Carolina | 28721 | United States |
| Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina | 27534 | United States |
| Wayne Memorial Hospital | Goldsboro | North Carolina | 27534 | United States |
| Cone Health Cancer Center | Greensboro | North Carolina | 27403 | United States |
| Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina | 28791 | United States |
| AdventHealth Hendersonville | Hendersonville | North Carolina | 28792 | United States |
| Onslow Memorial Hospital | Jacksonville | North Carolina | 28546 | United States |
| Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina | 28546 | United States |
| Novant Health Oncology Specialists-Kernersville | Kernersville | North Carolina | 27284 | United States |
| Cone Heath Cancer Center at Mebane | Mebane | North Carolina | 27302 | United States |
| Novant Health Oncology Specialists-Mount Airy | Mount Airy | North Carolina | 27030 | United States |
| CarolinaEast Medical Center | New Bern | North Carolina | 28561 | United States |
| CarolinaEast Oncology and Hematology Associates | New Bern | North Carolina | 28562 | United States |
| FirstHealth of the Carolinas-Moore Regional Hospital | Pinehurst | North Carolina | 28374 | United States |
| Annie Penn Memorial Hospital | Reidsville | North Carolina | 27320 | United States |
| Novant Health Oncology Specialists-Statesville | Stateville | North Carolina | 28625 | United States |
| Novant Health Oncology Specialists-Davidson County | Thomasville | North Carolina | 27360 | United States |
| Novant Health Oncology Specialists-Wilkesboro | Wilkesboro | North Carolina | 28659 | United States |
| Novant Health Forsyth Medical Center | Winston-Salem | North Carolina | 27103 | United States |
| Novant Health Oncology Specialists | Winston-Salem | North Carolina | 27103 | United States |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | United States |
| Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota | 58103 | United States |
| Sanford South University Medical Center | Fargo | North Dakota | 58103 | United States |
| Sanford Broadway Medical Center | Fargo | North Dakota | 58122 | United States |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | United States |
| Essentia Health - Jamestown Clinic | Jamestown | North Dakota | 58401 | United States |
| Indu and Raj Soin Medical Center | Beavercreek | Ohio | 45431 | United States |
| Strecker Cancer Center-Belpre | Belpre | Ohio | 45714 | United States |
| Saint Elizabeth Boardman Hospital | Boardman | Ohio | 44512 | United States |
| Dayton Physicians LLC-Miami Valley South | Centerville | Ohio | 45459 | United States |
| Miami Valley Hospital South | Centerville | Ohio | 45459 | United States |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | United States |
| Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | 45220 | United States |
| Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio | 45236 | United States |
| Bethesda North Hospital | Cincinnati | Ohio | 45242 | United States |
| TriHealth Cancer Institute-Westside | Cincinnati | Ohio | 45247 | United States |
| TriHealth Cancer Institute-Anderson | Cincinnati | Ohio | 45255 | United States |
| Mount Carmel East Hospital | Columbus | Ohio | 43213 | United States |
| Columbus Oncology and Hematology Associates Inc | Columbus | Ohio | 43214 | United States |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | United States |
| Grant Medical Center | Columbus | Ohio | 43215 | United States |
| The Mark H Zangmeister Center | Columbus | Ohio | 43219 | United States |
| Mount Carmel Health Center West | Columbus | Ohio | 43222 | United States |
| Doctors Hospital | Columbus | Ohio | 43228 | United States |
| Good Samaritan Hospital - Dayton | Dayton | Ohio | 45406 | United States |
| Miami Valley Hospital | Dayton | Ohio | 45409 | United States |
| Dayton Physician LLC-Miami Valley Hospital North | Dayton | Ohio | 45415 | United States |
| Miami Valley Hospital North | Dayton | Ohio | 45415 | United States |
| Delaware Health Center-Grady Cancer Center | Delaware | Ohio | 43015 | United States |
| Delaware Radiation Oncology | Delaware | Ohio | 43015 | United States |
| Grady Memorial Hospital | Delaware | Ohio | 43015 | United States |
| Dublin Methodist Hospital | Dublin | Ohio | 43016 | United States |
| Armes Family Cancer Center | Findlay | Ohio | 45840 | United States |
| Blanchard Valley Hospital | Findlay | Ohio | 45840 | United States |
| Orion Cancer Care | Findlay | Ohio | 45840 | United States |
| Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | United States |
| Dayton Physicians LLC-Atrium | Franklin | Ohio | 45005 | United States |
| Dayton Physicians LLC-Wayne | Greenville | Ohio | 45331 | United States |
| Wayne Hospital | Greenville | Ohio | 45331 | United States |
| Mount Carmel Grove City Hospital | Grove City | Ohio | 43123 | United States |
| Greater Dayton Cancer Center | Kettering | Ohio | 45409 | United States |
| First Dayton Cancer Care | Kettering | Ohio | 45420 | United States |
| Kettering Medical Center | Kettering | Ohio | 45429 | United States |
| Fairfield Medical Center | Lancaster | Ohio | 43130 | United States |
| OhioHealth Mansfield Hospital | Mansfield | Ohio | 44903 | United States |
| Marietta Memorial Hospital | Marietta | Ohio | 45750 | United States |
| OhioHealth Marion General Hospital | Marion | Ohio | 43302 | United States |
| Knox Community Hospital | Mount Vernon | Ohio | 43050 | United States |
| Licking Memorial Hospital | Newark | Ohio | 43055 | United States |
| Newark Radiation Oncology | Newark | Ohio | 43055 | United States |
| Southern Ohio Medical Center | Portsmouth | Ohio | 45662 | United States |
| Springfield Regional Cancer Center | Springfield | Ohio | 45504 | United States |
| Springfield Regional Medical Center | Springfield | Ohio | 45505 | United States |
| Dayton Physicians LLC-Upper Valley | Troy | Ohio | 45373 | United States |
| Upper Valley Medical Center | Troy | Ohio | 45373 | United States |
| Saint Joseph Warren Hospital | Warren | Ohio | 44484 | United States |
| Saint Ann's Hospital | Westerville | Ohio | 43081 | United States |
| Saint Elizabeth Youngstown Hospital | Youngstown | Ohio | 44501 | United States |
| Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | 43701 | United States |
| Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | 73120 | United States |
| Saint Alphonsus Medical Center-Baker City | Baker City | Oregon | 97814 | United States |
| Saint Charles Health System | Bend | Oregon | 97701 | United States |
| Clackamas Radiation Oncology Center | Clackamas | Oregon | 97015 | United States |
| Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon | 97015 | United States |
| Bay Area Hospital | Coos Bay | Oregon | 97420 | United States |
| Providence Newberg Medical Center | Newberg | Oregon | 97132 | United States |
| Saint Alphonsus Medical Center-Ontario | Ontario | Oregon | 97914 | United States |
| Providence Portland Medical Center | Portland | Oregon | 97213 | United States |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | United States |
| Kaiser Permanente Northwest | Portland | Oregon | 97227 | United States |
| Saint Charles Health System-Redmond | Redmond | Oregon | 97756 | United States |
| Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | 18103 | United States |
| Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | 18017 | United States |
| Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | 19010 | United States |
| Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | 19317 | United States |
| Main Line Health Center-Collegeville | Collegeville | Pennsylvania | 19426 | United States |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | United States |
| Pocono Medical Center | East Stroudsburg | Pennsylvania | 18301 | United States |
| Main Line Health Center-Exton | Exton | Pennsylvania | 19341 | United States |
| Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania | 18201 | United States |
| Lehigh Valley Hospital-Hazleton | Hazleton | Pennsylvania | 18201 | United States |
| Evangelical Community Hospital | Lewisburg | Pennsylvania | 17837 | United States |
| Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | 17837 | United States |
| Lewistown Hospital | Lewistown | Pennsylvania | 17044 | United States |
| Riddle Memorial Hospital | Media | Pennsylvania | 19063 | United States |
| Paoli Memorial Hospital | Paoli | Pennsylvania | 19301 | United States |
| Geisinger Cancer Services-Pottsville | Pottsville | Pennsylvania | 17901 | United States |
| Community Medical Center | Scranton | Pennsylvania | 18510 | United States |
| Geisinger Medical Oncology-Selinsgrove | Selinsgrove | Pennsylvania | 17870 | United States |
| Geisinger Medical Group | State College | Pennsylvania | 16801 | United States |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | United States |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | United States |
| AnMed Health Cancer Center | Anderson | South Carolina | 29621 | United States |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | United States |
| Prisma Health Cancer Institute - Laurens | Clinton | South Carolina | 29325 | United States |
| Prisma Health Cancer Institute - Easley | Easley | South Carolina | 29640 | United States |
| McLeod Regional Medical Center | Florence | South Carolina | 29506 | United States |
| Gibbs Cancer Center-Gaffney | Gaffney | South Carolina | 29341 | United States |
| Tidelands Georgetown Memorial Hospital | Georgetown | South Carolina | 29440 | United States |
| Saint Francis Hospital | Greenville | South Carolina | 29601 | United States |
| Prisma Health Cancer Institute - Butternut | Greenville | South Carolina | 29605 | United States |
| Prisma Health Cancer Institute - Faris | Greenville | South Carolina | 29605 | United States |
| Prisma Health Greenville Memorial Hospital | Greenville | South Carolina | 29605 | United States |
| Saint Francis Cancer Center | Greenville | South Carolina | 29607 | United States |
| Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | 29615 | United States |
| Prisma Health Cancer Institute - Greer | Greer | South Carolina | 29650 | United States |
| Gibbs Cancer Center-Pelham | Greer | South Carolina | 29651 | United States |
| Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | 29672 | United States |
| Spartanburg Medical Center | Spartanburg | South Carolina | 29303 | United States |
| Prisma Health Cancer Institute - Spartanburg | Spartanburg | South Carolina | 29307 | United States |
| MGC Hematology Oncology-Union | Union | South Carolina | 29379 | United States |
| Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | 57104 | United States |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | United States |
| Wellmont Bristol Regional Medical Center | Bristol | Tennessee | 37620 | United States |
| Memorial Hospital | Chattanooga | Tennessee | 37404 | United States |
| Pulmonary Medicine Center of Chattanooga-Hixson | Hixson | Tennessee | 37343 | United States |
| Wellmont Medical Associates Oncology and Hematology-Johnson City | Johnson City | Tennessee | 37604 | United States |
| Regional Cancer Center at Indian Path Community Hospital | Kingsport | Tennessee | 37660 | United States |
| Wellmont Holston Valley Hospital and Medical Center | Kingsport | Tennessee | 37660 | United States |
| Memorial GYN Plus | Ooltewah | Tennessee | 37363 | United States |
| Saint Joseph Regional Cancer Center | Bryan | Texas | 77802 | United States |
| American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah | 84003 | United States |
| Sandra L Maxwell Cancer Center | Cedar City | Utah | 84720 | United States |
| Logan Regional Hospital | Logan | Utah | 84321 | United States |
| Intermountain Medical Center | Murray | Utah | 84107 | United States |
| McKay-Dee Hospital Center | Ogden | Utah | 84403 | United States |
| Utah Valley Regional Medical Center | Provo | Utah | 84604 | United States |
| Riverton Hospital | Riverton | Utah | 84065 | United States |
| Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | 84106 | United States |
| LDS Hospital | Salt Lake City | Utah | 84143 | United States |
| Dixie Medical Center Regional Cancer Center | St. George | Utah | 84770 | United States |
| Wellmont Medical Associates-Bristol | Bristol | Virginia | 24201 | United States |
| Sovah Health Martinsville | Martinsville | Virginia | 24115 | United States |
| Bon Secours Memorial Regional Medical Center | Mechanicsville | Virginia | 23116 | United States |
| Bon Secours Saint Francis Medical Center | Midlothian | Virginia | 23114 | United States |
| Bon Secours DePaul Medical Center | Norfolk | Virginia | 23505 | United States |
| Southwest VA Regional Cancer Center | Norton | Virginia | 24273 | United States |
| Bon Secours Saint Mary's Hospital | Richmond | Virginia | 23226 | United States |
| Bon Secours Cancer Institute at Reynolds Crossing | Richmond | Virginia | 23230 | United States |
| Virginia Cancer Institute | Richmond | Virginia | 23230 | United States |
| Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | 23298 | United States |
| VCU Community Memorial Health Center | South Hill | Virginia | 23970 | United States |
| Bon Secours Health Center at Harbour View | Suffolk | Virginia | 23435 | United States |
| Shenandoah Oncology PC | Winchester | Virginia | 22601 | United States |
| Providence Regional Cancer System-Aberdeen | Aberdeen | Washington | 98520 | United States |
| MultiCare Auburn Medical Center | Auburn | Washington | 98001 | United States |
| Overlake Hospital Medical Center | Bellevue | Washington | 98004 | United States |
| PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | 98225 | United States |
| Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | 98310 | United States |
| Harrison Medical Center | Bremerton | Washington | 98310 | United States |
| Highline Medical Center-Main Campus | Burien | Washington | 98166 | United States |
| Providence Regional Cancer System-Centralia | Centralia | Washington | 98531 | United States |
| Swedish Cancer Institute-Edmonds | Edmonds | Washington | 98026 | United States |
| Saint Elizabeth Hospital | Enumclaw | Washington | 98022 | United States |
| Providence Regional Cancer Partnership | Everett | Washington | 98201 | United States |
| Saint Francis Hospital | Federal Way | Washington | 98003 | United States |
| MultiCare Gig Harbor Medical Park | Gig Harbor | Washington | 98335 | United States |
| Swedish Cancer Institute-Issaquah | Issaquah | Washington | 98029 | United States |
| Kadlec Clinic Hematology and Oncology | Kennewick | Washington | 99336 | United States |
| Providence Regional Cancer System-Lacey | Lacey | Washington | 98503 | United States |
| Saint Clare Hospital | Lakewood | Washington | 98499 | United States |
| PeaceHealth Saint John Medical Center | Longview | Washington | 98632 | United States |
| Jefferson Healthcare | Port Townsend | Washington | 98368 | United States |
| Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington | 98370 | United States |
| MultiCare Good Samaritan Hospital | Puyallup | Washington | 98372 | United States |
| Valley Medical Center | Renton | Washington | 98055 | United States |
| Pacific Gynecology Specialists | Seattle | Washington | 98104 | United States |
| Swedish Medical Center-Ballard Campus | Seattle | Washington | 98107 | United States |
| Kaiser Permanente Washington | Seattle | Washington | 98112 | United States |
| Swedish Medical Center-First Hill | Seattle | Washington | 98122-4307 | United States |
| Swedish Medical Center-Cherry Hill | Seattle | Washington | 98122-5711 | United States |
| PeaceHealth United General Medical Center | Sedro-Woolley | Washington | 98284 | United States |
| Providence Regional Cancer System-Shelton | Shelton | Washington | 98584 | United States |
| MultiCare Deaconess Cancer and Blood Specialty Center - Downtown | Spokane | Washington | 99204 | United States |
| MultiCare Deaconess Cancer and Blood Specialty Center - North | Spokane | Washington | 99218 | United States |
| MultiCare Deaconess Cancer and Blood Specialty Center - Valley | Spokane Valley | Washington | 99216 | United States |
| Franciscan Research Center-Northwest Medical Plaza | Tacoma | Washington | 98405 | United States |
| Mary Bridge Children's Hospital and Health Center | Tacoma | Washington | 98405 | United States |
| MultiCare Tacoma General Hospital | Tacoma | Washington | 98405 | United States |
| Northwest Medical Specialties PLLC | Tacoma | Washington | 98405 | United States |
| PeaceHealth Southwest Medical Center | Vancouver | Washington | 98664 | United States |
| Providence Saint Mary Regional Cancer Center | Walla Walla | Washington | 99362 | United States |
| Providence Regional Cancer System-Yelm | Yelm | Washington | 98597 | United States |
| ThedaCare Regional Cancer Center | Appleton | Wisconsin | 54911 | United States |
| Duluth Clinic Ashland | Ashland | Wisconsin | 54806 | United States |
| Northwest Wisconsin Cancer Center | Ashland | Wisconsin | 54806 | United States |
| Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | 53105 | United States |
| Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin | 54729 | United States |
| Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | 54701 | United States |
| Aurora Health Center-Fond du Lac | Fond du Lac | Wisconsin | 54937 | United States |
| Aurora Health Care Germantown Health Center | Germantown | Wisconsin | 53022 | United States |
| Aurora Cancer Care-Grafton | Grafton | Wisconsin | 53024 | United States |
| Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | 54301 | United States |
| Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin | 54303 | United States |
| Aurora BayCare Medical Center | Green Bay | Wisconsin | 54311 | United States |
| Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | 53142 | United States |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | United States |
| Marshfield Clinic - Ladysmith Center | Ladysmith | Wisconsin | 54848 | United States |
| Holy Family Memorial Hospital | Manitowoc | Wisconsin | 54221 | United States |
| Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | 54143 | United States |
| Saint Vincent Hospital Cancer Center at Marinette | Marinette | Wisconsin | 54143 | United States |
| Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | 54449 | United States |
| Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | 53209 | United States |
| Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | 53215 | United States |
| Aurora Sinai Medical Center | Milwaukee | Wisconsin | 53233 | United States |
| Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | 54548 | United States |
| Cancer Center of Western Wisconsin | New Richmond | Wisconsin | 54017 | United States |
| Saint Vincent Hospital Cancer Center at Oconto Falls | Oconto Falls | Wisconsin | 54154 | United States |
| Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | 54904 | United States |
| Aurora Cancer Care-Racine | Racine | Wisconsin | 53406 | United States |
| Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | 54868 | United States |
| HSHS Saint Nicholas Hospital | Sheboygan | Wisconsin | 53081 | United States |
| Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | 53081 | United States |
| Marshfield Clinic Stevens Point Center | Stevens Point | Wisconsin | 54482 | United States |
| Saint Vincent Hospital Cancer Center at Sturgeon Bay | Sturgeon Bay | Wisconsin | 54235-1495 | United States |
| Aurora Medical Center in Summit | Summit | Wisconsin | 53066 | United States |
| Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | 54241 | United States |
| Marshfield Clinic-Wausau Center | Wausau | Wisconsin | 54401 | United States |
| Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | 53226 | United States |
| Aurora West Allis Medical Center | West Allis | Wisconsin | 53227 | United States |
| Marshfield Clinic - Weston Center | Weston | Wisconsin | 54476 | United States |
| Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids | Wisconsin | 54494 | United States |
| Cheyenne Regional Medical Center-West | Cheyenne | Wyoming | 82001 | United States |
| Billings Clinic-Cody | Cody | Wyoming | 82414 | United States |
| Welch Cancer Center | Sheridan | Wyoming | 82801 | United States |
| Activated Surveys |
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| COMPLETED |
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| NOT COMPLETED |
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| T0: Baseline |
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| T1: 3 Months Survey |
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| T2: 6 Month Survey |
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| T3: 12 Month Survey |
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Baseline characteristics reported for individual completing the baseline survey
Not provided
| ID | Title | Description |
|---|---|---|
| BG000 | Observational (Questionnaire) | Patients complete questionnaires to assess financial burden |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean | Standard Deviation | years |
| |||||||||||||||||
| Sex: Female, Male | Count of Participants | Participants |
| ||||||||||||||||||
| Ethnicity (NIH/OMB) | Count of Participants | Participants |
| ||||||||||||||||||
| Race (NIH/OMB) | Count of Participants | Participants |
| ||||||||||||||||||
| Employment | Count of Participants | Participants |
| ||||||||||||||||||
| Cancer Type | Count of Participants | Participants |
| ||||||||||||||||||
| Cancer Stage at Enrollment | This can be defined either clinically or pathologically if they have already undergone surgery. For staging of both colon and rectal cancer, the definition of stage I-III is based on the seventh edition (2010) or an updated version of the TNM staging system. Higher stage indicates more advanced disease as defined int he TNM staging system. | Count of Participants | Participants |
| |||||||||||||||||
| Chemotherapy | Count of Participants | Participants |
|
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Comprehensive Score for Financial Toxicity (COST) | The Comprehensive Score for Financial Toxicity (COST) COST is an 11-item patient-reported outcome (PRO) of financial hardship that uses a 7-day time window and 5-point Likert response scale (ranging from 0, indicating not at all, to 4, very much). Higher COST scores (range, 0-44) represent better financial well-being. The primary objective is to evaluate the change in the level of self-reported financial burden from baseline (within 60 days of diagnosis) to 12 months from study registration. (12 mo - baseline) | Posted | Mean | Standard Deviation | score on a scale | Baseline and 12 months after cancer diagnosis |
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| Secondary | Reported Access and Utilization of Financial Services | Will evaluate reported access and utilization of financial services (i.e. financial counselor, navigator, social workers) and its association to financial burden in the first 12 months after diagnosis of colon or rectal cancer treated with curative-intent. Will be assessed by Consumer Based Cancer Care Value Index (CCVI). For the continuous item variable, will conduct the paired t test to examine the difference if the distribution is normal. If not normally distributed, Wilcoxon signed rank test will be used. For the categorical item variable, the paired proportion test (e.g., McNemar test) will be used instead. The association between CCVI and COST measures will be evaluated using the Pearson or Spearman correlation coefficient. | Not Posted | Up to 12 months | Participants | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | Change in Level of Self-reported Employment Limitations | Change in level of self-reported employment limitations from baseline to 6, 12 and 24 months after study registration will be assessed by Work Productivity and Activity Impairment Questionnaire for a Specific Health Problem (WPAI:SHP). WPAI outcomes are expressed as impairment percentages, with higher numbers indicating greater impairment and less productivity, i.e., worse outcomes, as follows: Questions:
Scores: Multiply scores by 100 to express in percentages. Percent work time missed due to problem: Q2/(Q2+Q4) Percent impairment while working due to problem: Q5/10 Percent overall work impairment due to problem: Q2/(Q2+Q4)+[(1-(Q2/(Q2+Q4)))x(Q5/10)] Percent activity impairment due to problem: Q6/10 | Posted | Mean | Standard Deviation | percentage of activity impaired | Baseline, 6, 12, and 24 months after cancer diagnosis |
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| Secondary | Level of Self-reported Employment Limitations (Dichotomized) | Change in level of self-reported employment limitations from baseline to 6, 12 and 24 months after study registration will be assessed by Work Productivity and Activity Impairment Questionnaire for a Specific Health Problem (WPAI:SHP). WPAI outcomes are expressed as impairment percentages, with higher numbers indicating greater impairment and less productivity, i.e., worse outcomes. These outcomes were further dichotomized at 50%, such that Impairment > 50% was considered impaired and Impairment <=50% was not-impaired | Posted | Count of Participants | Participants | Baseline, 6, 12, and 24 months after cancer diagnosis |
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| Secondary | Long Term Outcomes After Diagnosis for Adherence | Will evaluate long term outcomes at 24 months after diagnosis for adherence to clinical follow-up guidelines. Specially, linear (or generalized linear) mixed model will be fit to study the change in the mean response over time. In case the changes in the mean response over time are not linear, the quadratic trends or non-linear trends via spline may be considered in the modeling. Interactions will be evaluated as well. | Not Posted | At 24 months | Participants | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | Long Term Outcomes After Diagnosis for Financial Burden | Will evaluate long term outcomes at 24 months after diagnosis for financial burden. Specially, linear (or generalized linear) mixed model will be fit to study the change in the mean response over time and also the effects of cancer type, stage, treatment plan and demographics, etc. on financial burden. In case the changes in the mean response over time are not linear, the quadratic trends or non-linear trends via spline may be considered in the modeling. Interactions will be evaluated as well. | Not Posted | At 24 months | Participants | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | Long Term Outcomes After Diagnosis for Employment Limitations | Will evaluate long term outcomes at 24 months after diagnosis for employment limitations. Specially, linear (or generalized linear) mixed model will be fit to study the change in the mean response over time. In case the changes in the mean response over time are not linear, the quadratic trends or non-linear trends via spline may be considered in the modeling. Interactions will be evaluated as well. | Not Posted | At 24 months | Participants | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | Change of Quality-of-life (QoL) Outcome | Will evaluate the change of QoL from baseline to 12 months and its association with predictors. Will be evaluated by Functional Assessment of Cancer Therapy-General. | Not Posted | Baseline up to 12 months | Participants | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | Changes Self-reported Financial Burden Between Baseline and 12 Month [EORTC] | Financial Burden was evaluated using a single item from European Organization for Research and Treatment of Cancer Questionnaire 30 [EORT30]) with responses for both baseline and 12 months EORTC30 question: Has your physical condition or medical treatment caused you financial difficulties?
| participants who completed both the baseline and 12 month EORTC questionnaire | Posted | Count of Participants | Participants | Baseline and12 months |
|
up to 24 months
This is an observational study which only collected All-Cause Mortality and Serious Adverse Events, other adverse event data was not collected
Not provided
| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Before Completing Any Questionaire | Patients registered for participation but off study before completing any study questionnaire: Quality-of-Life Assessment: Ancillary studies Questionnaire Administration: Ancillary studies | 13 | 57 | 13 | 57 | 0 | 0 |
| EG001 | Observational (Questionnaire) Baseline Questionnaire | All Patients complete questionnaires over 20-60 minutes after cancer diagnosis at baseline Quality-of-Life Assessment: Ancillary studies Questionnaire Administration: Ancillary studies | 0 | 455 | 0 | 455 | 0 | 0 |
| EG002 | Observational (Questionnaire) 3 Months | All Patients complete questionnaires over 20-60 minutes at 3 months after cancer diagnosis. Quality-of-Life Assessment: Ancillary studies Questionnaire Administration: Ancillary studies | 5 | 301 | 4 | 301 | 0 | 0 |
| EG003 | Observational (Questionnaire) 6 Months | All Patients complete questionnaires over 20-60 minutes at 6 months after cancer diagnosis. Quality-of-Life Assessment: Ancillary studies Questionnaire Administration: Ancillary studies | 5 | 272 | 4 | 272 | 0 | 0 |
| EG004 | Observational (Questionnaire) 12 Months | All Patients complete questionnaires over 20-60 minutes at 12 months after cancer diagnosis. Quality-of-Life Assessment: Ancillary studies Questionnaire Administration: Ancillary studies | 4 | 233 | 12 | 233 | 0 | 0 |
| EG005 | Observational (Questionnaire) 24 Months | All Patients complete questionnaires over 20-60 minutes at 24 months after cancer diagnosis. Quality-of-Life Assessment: Ancillary studies Questionnaire Administration: Ancillary studies | 2 | 245 | 2 | 245 | 0 | 0 |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Death Nos | General disorders | MedDRA 10.0) | Non-systematic Assessment |
|
Not provided
Not provided
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Study Statistician | ECOG-ACRIN Statistical Office | 617-632-3012 | eatrials@jimmy.harvard.edu |
| Jul 8, 2024 |
| Prot_SAP_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Jun 19, 2019 | Jul 8, 2024 | ICF_001.pdf |
| ID | Term |
|---|---|
| D003110 | Colonic Neoplasms |
| D012004 | Rectal Neoplasms |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
Not provided
Not provided
| Unknown or Not Reported |
|
| Native Hawaiian or Other Pacific Islander |
|
| Black or African American |
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| White |
|
| More than one race |
|
| Unknown or Not Reported |
|
| Unemployed |
|
| Not Answered |
|
| Rectosigmoid Junction |
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| Stage III |
|
| Equivalence |
No margin of equivalence |
| Baseline COST effect on change in COST The linear (non-longitudinal) model of [change in COST from baseline to 12-month follow-up] included covariates for: age, Baseline COST score, cancer stage, cancer type, chemotherapy, comorbidities, education, FACT-G7, gender, income, marital status, insurance status, race, safety-net hospital, self-efficacy, NDI. Null: All estimates are equal | Regression, Linear | <0.001 | P value: For the categorical variable with more than 2 levels, this is the p value from the overall test of the null hypothesis that all estimates are equal against the alternative that at least one is different. | Slope | -0.4 | 2-Sided | 95 | -0.6 | -0.3 | Equivalence | No margin of equivalence |
| Cancer type (Colon cancer, Rectal cancer and Rectosigmoid) effect on change in COST The linear (non-longitudinal) model of [change in COST from baseline to 12-month follow-up] included covariates for: age, Baseline COST score, cancer stage, cancer type, chemotherapy, comorbidities, education, FACT-G7, gender, income, marital status, insurance status, race, safety-net hospital, self-efficacy, NDI. Null: All estimates are equal | Regression, Linear | 0.002 | This is the p value of the null hypothesis that COST estimates for all cancer types (Colon cancer, Rectal cancer and Rectosigmoid) are equal against the alternative that at least one is different. | Equivalence | No margin of equivalence |
| FACT-G7 effect on change in COST The linear (non-longitudinal) model of [change in COST from baseline to 12-month follow-up] included covariates for: age, Baseline COST score, cancer stage, cancer type, chemotherapy, comorbidities, education, FACT-G7, gender, income, marital status, insurance status, race, safety-net hospital, self-efficacy, NDI. Null: All estimates are equal | Regression, Linear | 0.03 | Slope | 0.3 | 2-Sided | 95 | 0.0 | 0.6 | Equivalence | No margin of equivalence |
| Gender effect on change in COST The linear (non-longitudinal) model of [change in COST from baseline to 12-month follow-up] included covariates for: age, Baseline COST score, cancer stage, cancer type, chemotherapy, comorbidities, education, FACT-G7, gender, income, marital status, insurance status, race, safety-net hospital, self-efficacy, NDI. Null: All estimates are equal | Regression, Linear | 0.13 | Slope | 1.6 | 2-Sided | 95 | -0.5 | 3.7 | Equivalence | No margin of equivalence |
| RACE (White. Black Other) effect on change in COST The linear (non-longitudinal) model of [change in COST from baseline to 12-month follow-up] included covariates for: age, Baseline COST score, cancer stage, cancer type, chemotherapy, comorbidities, education, FACT-G7, gender, income, marital status, insurance status, race, safety-net hospital, self-efficacy, NDI. Null: All estimates are equal | Regression, Linear | 0.91 | This is the p value of the null hypothesis that COST estimates for all RACES (White, Black, other) are equal against the alternative that at least one is different. | Equivalence | No margin of equivalence |
| Neighborhood Deprivation (NDI) effect on change in COST The linear (non-longitudinal) model of [change in COST from baseline to 12-month follow-up] included covariates for: age, Baseline COST score, cancer stage, cancer type, chemotherapy, comorbidities, education, FACT-G7, gender, income, marital status, insurance status, race, safety-net hospital, self-efficacy, NDI. Higher NDI = greater neighborhood deprivation | Regression, Linear | >0.99 | Slope | 0.0 | 2-Sided | 95 | -0.3 | 0.3 | Equivalence | No margin of equivalence |
Patient questionnaires completed at 12 months after cancer diagnosis. |
| OG003 | 24-month Questionnaire | Patient questionnaires completed at 24 months after cancer diagnosis. |
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Patient questionnaires completed at 24 months after cancer diagnosis.
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| Impaired ( score <=50%) |
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| Impaired ( score <=50%) |
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| Impaired ( score <=50%) |
|