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In this prospective randomized clinical trial we plan to compare two fertilization method which are widely used during in vitro fertilization (IVF) treatment. Outcome of conventional IVF and intracytoplasmic sperm injection (ICSI) treatment will be compared in this study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IVF | Experimental | Oocytes fertilized by conventional in vitro fertilization (IVF) method |
|
| ICSI | Experimental | Oocytes fertilized by intracytoplasmic sperm injection (ICSI) method |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ICSI | Procedure | Oocytes are fertilized by conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fertilization rate | Number of oocytes fertilized | 18 hours after insemination |
| Measure | Description | Time Frame |
|---|---|---|
| Embryo quality | Number and quality of blastomeres, amount of fragmentation, embryo grade | 36 and 72 hours after fertilization |
| Implantation rate | Number of embryos implanted (/number of embryos transferred) |
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Inclusion Criteria:
Infertile patients entering in vitro fertilization treatment At least 1 oocytes collected Semen sample is suitable for IVF and ICSI fertilization as well Number of oocytes collected is lower than 5 AND/OR female age is equal or more than 40 years
Exclusion Criteria:
Samen sample is not suitable for conventional IVF fertilization Previous conventional IVF treatment resulted in <50% fertilization rate
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Peter Fancsovits, PhD | Contact | +36208250520 | fancsovits.peter@noi1.sote.hu | |
| Janos Urbancsek, DSc | Contact | +3612660115 | urbancsek.janos@noi1.sote.hu |
| Name | Affiliation | Role |
|---|---|---|
| Peter Fancsovits, PhD | Semmelweis University First Department of Obstetrics and Gynecology, Budapest, Hungary | Study Chair |
| Janos Urbancsek, DSc | Semmelweis University First Department of Obstetrics and Gynecology, Budapest, Hungary |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Semmelweis University First Department of Obstetrics and Gynecology | Budapest | 1088 | Hungary |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D020554 | Sperm Injections, Intracytoplasmic |
| ID | Term |
|---|---|
| D005307 | Fertilization in Vitro |
| D027724 | Reproductive Techniques, Assisted |
| D012099 | Reproductive Techniques |
| D013812 | Therapeutics |
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| 4 weeks after embryo transfer |
| Clinical pregnancy rate | Number of clinical pregnancies (/No. of embryo transfers) | 4 weeks after the embryo transfer |
| Csaba Pribenszky, PhD | University of Veterinary Science, Budapest, Hungary | Principal Investigator |
| Adam Lehner, PhD | Semmelweis University First Department of Obstetrics and Gynecology, Budapest, Hungary | Principal Investigator |
| Zita Kaszás, BSc | Semmelweis University First Department of Obstetrics and Gynecology, Budapest, Hungary | Principal Investigator |
| Miklós I Ács, MD | Klinikum Kempten Oberallgäu, Kempten, Germany | Principal Investigator |
| D008919 | Investigative Techniques |