Metformin Plus Insulin on Non-obese Autoimmune Diabetes

The Effect of Metformin as add-on to Insulin in Non-obese Patients With Autoimmune Diabetes

The objective of this study is to evaluate the therapeutic effect of metformin as additional treatment with insulin on non-obese autoimmune diabetes.

Inclusion Criteria:

• Type 1 diabetes according to ADA criterias <5 years.
• Age≥ 18 years and less than 70 years.
• Non-obese: defined as BMI less than 28 kg/m2
• Positive for at least one of the anti-islet autoantibodies: GADA, IA2A, ZnT8A
• Fasting or postprandial plasma C-peptide more than 100 pmol/L
• Written informed consent from the patient or family representative.

Exclusion Criteria:

• History of any malignancy or other severe diseases
• Female patients who are pregnant or breastfeeding before or during the three-year follow-up
• Poor compliance or refusal to participate.