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The aim of this study is to investigate the clinical value of [18F]aluminum fluoride-1,4,7-triazacyclononane-1,4,7-triacetic acid-octreotide（18F-AlF-NOTA-octreotide ） positron emission tomography / computed tomography (PET/CT) in patients with neuroendocrine neoplasms (NENs).
18F-AlF-NOTA-octreotide is a radioligand targeting the somatostatin receptor, which is widely expressed on the cell surface of NENs. The radioligand can be used for the diagnosis and stage of the NENs. A total of 5 volunteers and 60 NEN patients will be subjected to a 18F-AlF-NOTA-octreotide PET/CT scan. The uptake of 18F-AlF-NOTA-octreotide in organs and tumor lesions will be quantified as Standardized Uptake Values (SUVmax/SUVmean).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 18F-AlF-NOTA-octreotide PET/CT | Experimental | One injection of the radioligand 18F-AlF-NOTA-octreotide |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 18F-AlF-NOTA-octreotide | Drug | One injection of 18F-AlF-NOTA-octreotide |
|
| Measure | Description | Time Frame |
|---|---|---|
| 18F-AlF-NOTA-octreotide PET/CT imaging of patients with Neuroendocrine Neoplasms | The radioligand 18F-AlF-NOTA-octreotide can be used to visualize neuroendocrine neoplasms | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| 18F-AlF-NOTA-octreotide PET/CT prognostic factor for overall and disease specific survival | The uptake of the 18F-AlF-NOTA-octreotide in neuroendocrine neoplasm lesions (quantified as Standard Uptake Values) is associated with overall and disease specific free survival (PFS) neuroendocrine neoplasms | 24 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tingting Long, MD,Phd | Contact | +86 13549682646 | longtingting@csu.edu.cn | |
| Shuo Hu, professor | Contact | +86 15874210819 | hushuo_xy@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Tingting Long, MD,Phd | Department of PET Center,Xiangya Hospital, Central South University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of PET Center,Xiangya Hospital,Central South University | Recruiting | Changsha | Hunan | 410008 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20150268 | Result | Laverman P, McBride WJ, Sharkey RM, Eek A, Joosten L, Oyen WJ, Goldenberg DM, Boerman OC. A novel facile method of labeling octreotide with (18)F-fluorine. J Nucl Med. 2010 Mar;51(3):454-61. doi: 10.2967/jnumed.109.066902. Epub 2010 Feb 11. |
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| ID | Term |
|---|---|
| D018358 | Neuroendocrine Tumors |
| ID | Term |
|---|---|
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| C000711267 | Al18F-NOTA-octreotide |
| D000072078 | Positron Emission Tomography Computed Tomography |
| ID | Term |
|---|---|
| D049268 | Positron-Emission Tomography |
| D014055 | Tomography, Emission-Computed |
| D007090 | Image Interpretation, Computer-Assisted |
| D003952 | Diagnostic Imaging |
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| PET/CT | Device | Following injection of 18F-AlF-NOTA-octreotide the participants will be subjected to whole body PET/CT |
|
| D009380 | Neoplasms, Nerve Tissue |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D014057 | Tomography, X-Ray Computed |
| D064847 | Multimodal Imaging |
| D011856 | Radiographic Image Enhancement |
| D007089 | Image Enhancement |
| D010781 | Photography |
| D011859 | Radiography |
| D014056 | Tomography, X-Ray |
| D011877 | Radionuclide Imaging |
| D014054 | Tomography |
| D003947 | Diagnostic Techniques, Radioisotope |