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| ID | Type | Description | Link |
|---|---|---|---|
| 2017-A00875-48 | Other Identifier | Agence Nationale de Sécurité du médicament et des produits de Santé |
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This study should lead to the validation of the concept of the autoAc directed against the neuropeptides involved in food intake regulation.
Eating disorders are a public health issue. It has been recently reported the importance of immune system modifications in eating disorders physiopathology, involving autoantibodies directed against neuropeptides regulating food intake. A recent study of laboratory INSERM 1073 showed the existence of an intestinal bacterial protein exhibiting structural similarities with α-MSH: ClpB. The autoAc directed against the latter also react with α-MSH because of these similarity of structures, thus leading to a potential digestive origin of these autoAc. To consolidate this new etiopathogenic assumption, a large clinical study is necessary with analysis of patients autoAc profiles. a monocentric study with inclusion of 240 patients over 2 years and 80 healthy volunteers is proposed.
This study should lead to the validation of the concept of the autoAc directed against the neuropeptides involved in food intake regulation. Nutritional modulations (probiotic, amino-acid…) could constitute an interesting therapeutic perspective in the future.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Eating disorders patients | Experimental | first clinical visit in nutrition department of CHU de Rouen for eating disorders (anorexia nervosa, hyperphagia or bulimia) according to the classification DSM-V |
|
| healthy volunteers | Other | Volunteers with negative SCOFF test (No active or history of eating disorders) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Evaluation of the rates of the autoantibodies directed against the neuropeptides (ghrelin and alpha-MSH) controlling involved in food intake regulation | Other | blood samples (12ml) and stool samples (30g) collections |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of the rates of the autoantibodies directed against the neuropeptides (ghrelin and alpha-MSH) involved in food intake regulation among patients with eating disorders | blood samples collections | 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Scale for determination factors associated with eating disorders | A global scale will evaluate :
| 1 week |
| statute in autoantibody and behavioral characteristics of the eating disorder |
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Inclusion Criteria:
Patients with eating disorders
Volunteers
Exclusion criteria:
Patients with eating disorders
Volunteers
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| Name | Affiliation | Role |
|---|---|---|
| Najate EL MACHKOURI ACHAMRAH, MD, PhD | University Hospital, Rouen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre d'Investigation Clinique | Rouen | 76031 | France |
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Eating disorders compared to healthy volonteers
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|
quality of life and the psychological state of the patients tests |
| 1 week |
| Evaluation of the rate of the autoantibodies directed against bacterial peptide, ClpB among patients presenting with eating disorders | stoll samples collections | 1 week |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D054439 | Ghrelin |
| D000521 | alpha-MSH |
| D001069 | Appetite Regulation |
| D049071 | Endopeptidase Clp |
| ID | Term |
|---|---|
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D011333 | Pro-Opiomelanocortin |
| D007028 | Hypothalamic Hormones |
| D009074 | Melanocyte-Stimulating Hormones |
| D053486 | Melanocortins |
| D010908 | Pituitary Hormones, Anterior |
| D010907 | Pituitary Hormones |
| D009479 | Neuropeptides |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D001066 | Appetite |
| D006815 | Hunger |
| D004068 | Digestive System Physiological Phenomena |
| D055688 | Digestive System and Oral Physiological Phenomena |
| D057065 | ATP-Dependent Endopeptidases |
| D049069 | ATP-Dependent Proteases |
| D000074183 | ATPases Associated with Diverse Cellular Activities |
| D000074582 | AAA Proteins |
| D017766 | Acid Anhydride Hydrolases |
| D006867 | Hydrolases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
| D000251 | Adenosine Triphosphatases |
| D010447 | Peptide Hydrolases |
| D010450 | Endopeptidases |
| D002352 | Carrier Proteins |
| D024101 | Mitochondrial Proteins |
| D060365 | Chloroplast Proteins |
| D010940 | Plant Proteins |
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