Constipated patients in the participating center from February 2017 to June 2018 (anticipated) were prospectively enrolled. Number of defecation per week，Bristol score，and Colon transmission experiment were compared with the constipated patients before treatment.

Constipation affects the quality of life of patients, some patients abuse laxatives or repeated medical treatment, increased medical costs. At present, the main treatment of constipation is to adjust life style, medicine, psychotherapy, biofeedback and surgical treatment. However, the above methods are associated with adverse reactions, and the patient's satisfaction is still low. A new approach is needed to solve this clinical problem.

Investigators have developed a vibration capsule that can be adjusted in different modes.

Preliminary animal experiments showed that the capsule was safe and increased the number of defecation.

This study is a clinical research for patients with constipation, to explore the effect in different vibrating modes in patients with constipation and tract emptying transmission and its effectiveness.

Inclusion Criteria:

• Adult patients aged form 18 to 80
• Clinical diagnosis of functional constipation
• Must be able to swallow vibrating capsule

Exclusion Criteria:

• complex history of gastrointestinal diverticula, obstruction, ulcer, bleeding, stenosis or fistula.
• recent use of banned drugs.
• patients who are preparing for mri.

We may share IPD when we finish this research