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Does mixing alcohol make hangover worse?
Hangover is the most commonly occurring morbidity associated with heavy drinking.
Our aim was to test the hypothesis that mixing alcoholic drinks as compared to drinking one type of alcohol only (beer, wine or spirits) associate with a higher alcohol intake and worse hangover.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| single type | Experimental | Restricted to drinking only one type of alcohol |
|
| mixed type | Active Comparator | Drinking and mixing different types of alcohols freely |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mixing alcohol | Dietary Supplement | Alcoholic beverages, different types |
|
| Measure | Description | Time Frame |
|---|---|---|
| Acute Hangover Severity Scale (AHSS) | AHSS is a 12-item alcohol hangover measurement tool recommended for application in hangover research with a predictive validity of 92.4 %, significantly higher than that of other hangover scales (Penning et al., 2012). Alcohol hangover was measured thrice the day after drinking; in the morning immediately after waking up, at midday, and in the afternoon. The individual participant assessed his or her own hangover the day after. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Number of drinks | Total number of drinks defined as 12 g of alcohol consumed during evening | Baseline |
| Acute Hangover Severity Scale (AHSS) 2 | AHSS is a 12-item alcohol hangover measurement tool recommended for application in hangover research with a predictive validity of 92.4 %, significantly higher than that of other hangover scales (Penning et al., 2012). Alcohol hangover was measured thrice the day after drinking; in the morning immediately after waking up, at midday, and in the afternoon. The individual participant assessed his or her own hangover the day after. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ole G Christiansen, MD | Zealand University Hospital | Principal Investigator |
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| ID | Term |
|---|---|
| D019973 | Alcohol-Related Disorders |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000431 | Ethanol |
| D049031 | Sarcoglycans |
| ID | Term |
|---|---|
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D049029 | Dystrophin-Associated Proteins |
| D009124 | Muscle Proteins |
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| Single type alcohol | Dietary Supplement | Alcoholic beverages, different types |
|
|
| after 4 hours |
| Acute Hangover Severity Scale (AHSS) 3 | AHSS is a 12-item alcohol hangover measurement tool recommended for application in hangover research with a predictive validity of 92.4 %, significantly higher than that of other hangover scales (Penning et al., 2012). Alcohol hangover was measured thrice the day after drinking; in the morning immediately after waking up, at midday, and in the afternoon. The individual participant assessed his or her own hangover the day after. | after 8 hours |
| D003285 |
| Contractile Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D008565 | Membrane Proteins |
| D008562 | Membrane Glycoproteins |