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Comparison of a randomized, double-blind, and control-group study for the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants
The aim is to investigate the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants by a randomized, double-blind, and control-group study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CTP group | Experimental | 1,000 mg of collagen tripeptide (CTP) was orally administered per day for 12 weeks. |
|
| Control group | Placebo Comparator | 1,000 mg of placebo (starch) was orally administered per day for 12 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CTP | Dietary Supplement | 1,000 mg of CTP was orally administered per day for 12 weeks. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| changes in Transepidermal Waterloss by Tewameter | comparison between baseline, after 6 weeks, and after 12 weeks | baseline, after 6 weeks, and after 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| changes in skin wrinkling indices by Visiometer | comparison between baseline, after 6 weeks, and after 12 weeks | baseline, after 6 weeks, and after 12 weeks |
| skin elasticity by Cutometer | comparison between baseline, after 6 weeks, and after 12 weeks |
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Inclusion Criteria:
- > = 4 of Tewameter
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sang Yeoup Lee, MD | Integrated Research Institute for Natural Ingredients and Functional Foods | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Integrated Research Institute for Natural Ingredients and Functional Foods | Yangsan | 50612 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33521019 | Derived | Tak YJ, Shin DK, Kim AH, Kim JI, Lee YL, Ko HC, Kim YW, Lee SY. Effect of Collagen Tripeptide and Adjusting for Climate Change on Skin Hydration in Middle-Aged Women: A Randomized, Double-Blind, Placebo-Controlled Trial. Front Med (Lausanne). 2021 Jan 11;7:608903. doi: 10.3389/fmed.2020.608903. eCollection 2020. |
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| ID | Term |
|---|---|
| D012877 | Skin Manifestations |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D003570 | Cytidine Triphosphate |
| ID | Term |
|---|---|
| D003597 | Cytosine Nucleotides |
| D011742 | Pyrimidine Nucleotides |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
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| placebo (starch) |
| Dietary Supplement |
placebo (starch) |
|
| baseline, after 6 weeks, and after 12 weeks |
| changes in hydration level of the skin surface by Corneometer | comparison between baseline, after 6 weeks, and after 12 weeks | baseline, after 6 weeks, and after 12 weeks |
| D006571 |
| Heterocyclic Compounds |
| D009711 | Nucleotides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D012265 | Ribonucleotides |