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Pain is the most prevalent non-motor symptom in Parkinson disease, and the motor improvement not always is related to the pain improvement with the medication treatment. By this, we are testing a non-invasive method called transcranial magnetic stimulation as an alternative to treat pain related to Parkinson disease. This technique can lead to either inhibitory or excitatory effects in brain circuits depending on stimulation parameters, and is known to provide analgesic effects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| deep rTMS-active doble coil | Active Comparator | patients undergoing of deep rTMS real with doble coil |
|
| deep rTMS-sham | Sham Comparator | patients undergoing to placebo deep rTMS |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| deep rTMS | Device |
| ||
| placebo deep rTMS |
| Measure | Description | Time Frame |
|---|---|---|
| Change in baseline of Pain | assessing by Visual Analog Scale for Pain (VAS). This scale range from 0 (no pain) to 10 (maximum pain), being considered an effective improvement in the patient's pain when the pain decreases at least in 30% from the basal score. | base line (moment of inclusion), day 15th, day 45th and in the last day of the sessions of rTMS (4X in two months) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Daniel MD Ciampi, Phd | Contact | + 55 11 997753538 | ciampi@usp.br | |
| Victor MD Barboza, PhD student | Contact | + 55 11 997017706 | victors.rb@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC/FMUSP) | Recruiting | São Paulo | São Paulo | 05403900 | Brazil |
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| ID | Term |
|---|---|
| D010146 | Pain |
| D010300 | Parkinson Disease |
| D059350 | Chronic Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D020734 | Parkinsonian Disorders |
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|
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |