REsting and Stimulus-based Paradigms to Detect Organized NetworkS and Predict Emergence of Consciousness

Advanced MRI and EEG to Predict Recovery of Consciousness After Severe Traumatic Brain Injury

The aim of this study is to assess the utility of advanced magnetic resonance imaging (MRI) and electroencephalographic (EEG) technologies for predicting functional outcomes in patients with severe traumatic brain injury (TBI).

Patients:

Inclusion Criteria:

• Traumatic Brain Injury
• Glasgow Coma Scale score of 3-8 within 24 hours, unconfounded by sedation, paralysis, hypoxia, hypotension, hypothermia, or concurrent medical illness
• Clinical evidence of disorder of consciousness defined as coma, VS, or MCS

Exclusion Criteria:

• History of prior severe brain injury or dementia
• Emergence from MCS at time of initial CRS-R assessment

Healthy Subjects:

Exclusion Criteria:

History of brain injury or neurological disease, psychiatric disease, or any history of diabetes, high blood pressure, heart disease, or kidney disease