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Comprehensive assessment of human vasodilatory effect of GLP-1 in forearm and coronary arteries
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GLP-1 (7-36)Amide | Drug | IV infusion |
| Measure | Description | Time Frame |
|---|---|---|
| Change in IMR (index of microcirculatory resistance) with GLP-1 compared with baseline | Change in coronary microcirculatory resistance from baseline | Change from baseline |
| Forearm bloodflow ratio with GLP-1 | Peripheral vasodilatory response of GLP-1 | Change from baseline |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35470686 | Derived | Aetesam-Ur-Rahman M, Zhao TX, Paques K, Oliveira J, Khialani B, Kyranis S, Braganza DM, Clarke SC, Bennett MR, West NEJ, Hoole SP. Coronary Flow Variations Following Percutaneous Coronary Intervention Affect Diastolic Nonhyperemic Pressure Ratios More Than the Whole Cycle Ratios. J Am Heart Assoc. 2022 May 3;11(9):e023554. doi: 10.1161/JAHA.121.023554. Epub 2022 Apr 26. | |
| 33932990 |
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| ID | Term |
|---|---|
| D023921 | Coronary Stenosis |
| D060050 | Angina, Stable |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| C055453 | glucagon-like peptide 1 (7-36)amide |
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| Derived |
| Aetesam-Ur-Rahman M, Giblett JP, Khialani B, Kyranis S, Clarke SJ, Zhao TX, Braganza DM, Clarke SC, West NEJ, Bennett MR, Hoole SP. GLP-1 vasodilatation in humans with coronary artery disease is not adenosine mediated. BMC Cardiovasc Disord. 2021 May 1;21(1):223. doi: 10.1186/s12872-021-02030-5. |
| D014652 |
| Vascular Diseases |
| D000787 | Angina Pectoris |
| D002637 | Chest Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |