Nobio Antimicrobial Particles Effect in a Split Mouth Model

Nobio Antimicrobial Particles Effect in a Split Mouth Model

The study purpose is to evaluate the antimicrobial effect of Nobio particles incorporated within Novidia Dental Bonding and Flowable Composite versus standard of care within a split mouth model.The study population will include 35 subjects considered to be at high risk for cervical caries and affected by uncontrolled plaque accumulation

An exploratory, comparative, self-controlled single blinded interventional study. Intended to evaluate the antimicrobial effect of Nobio particles incorporated within Novidia Dental Bonding and Flowable composite versus Filtek bond and flow composite within a split mouth model.The study population (N=35) will be high risk population for cervical caries (with at least 2 carious cavities in the mouth) affected by uncontrolled plaque accumulation.Each subject will serve in this model as his own control.On one side the Novidia intervention will be made and on the contralateral side the Filtek intervention.

Inclusion Criteria:

• Male or female over 18 years of age.
• Requires two cervical restorations or the exchange of existing ones
• Subject has poor oral hygiene and at high risk for plaque accumulation.
• Subject able and willing to comply with study visits and Follow up visits and signed the informed consent.

Exclusion Criteria:

• Allergic reaction to iodide.
• Pregnant or lactating women.
• Use of antiseptic mouth rinse or antibiotic up to 2 weeks before the beginning of study.

Exclusion criteria for the chosen teeth for the study:

• Tooth designated for extraction in the following 6 month.
• Tooth designated to have a root canal treatment.
• Tooth or several teeth designated for periodontal surgery.