Effects of Nicotinamide Riboside on Metabolism and Vascular Function

Effects of Nicotinamide Riboside on Metabolism and Vascular Function

The purpose of this study is to determine the effects of Nicotinamide Riboside (NR) supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.

The purpose of this study is to determine the effects of 7 days of Nicotinamide Riboside (NR) or placebo supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.

Inclusion Criteria:

• Age 18 to 35 (young) and 60 to 75 (older)
• Normo- or pre-hypertensive (blood pressure <140/90 mmHg)
• Non-smokers
• Able to give informed consent and participate in all laboratory visits

Exclusion Criteria:

• Currently taking any medications that could interfere with cardiovascular or metabolic outcomes will be excluded from the study (e.g., beta-blockers)
• Known metabolic (e.g. Type I or Type II diabetes, cardiovascular disease, etc.) or immunologic (e.g. HIV, cancer, autoimmune, etc.) diseases
• Food allergies to egg, milk, soy or wheat
• Women who are pregnant or planning to become pregnant during the course of the study,
• Pacemaker or other implanted device
• Unwilling to participate in the experimental protocol or blood draws will be excluded