A Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy... | NCT03498716 | Trialant

A Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy... | NCT03498716 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Non-metastatic operable Stage II-III breast cancer

Histologically documented TNBC (Triple Negative Breast Cancer)

Confirmed tumor PD-L1 evaluation as documented through central testing of a representative tumor tissue specimen

Adequately excised: Patients must have undergone either breast-conserving surgery or mastectomy/nipple- or skin-sparing mastectomy

Adequate hematologic and end-organ function

For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures

For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures and agreement to refrain from donating sperm.

No more than 8 weeks (56 days) may elapse between definitive breast surgery and randomization.

Representative formalin-fixed, paraffin embedded (FFPE) tumor specimen from surgical resection in paraffin blocks (preferred) or at least 25 unstained slides.

Exclusion Criteria

Prior history of invasive breast cancer

For the currently diagnosed breast cancer, any previous systemic anti-cancer treatment (e.g., neoadjuvant or adjuvant), including, but not limited to, chemotherapy, anti-HER2 therapy.

Previous therapy with anthracyclines or taxanes for any malignancy

Cardiopulmonary dysfunction

Prior malignancies within 5 years prior to randomization, with the exception of those with a negligible risk of metastasis or death and treated with expected curative outcome

Active or history of autoimmune disease or immune deficiency

History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screening chest computed tomography (CT) scan

Urinary outflow obstruction

Active tuberculosis

Major surgical procedure other than for diagnosis within 4 weeks prior to initiation of study treatment or anticipation of need for a major surgical procedure during study treatment or within 5 months following the last dose of Atezolizumab (for patients randomized to Atezolizumab)

Prior allogeneic stem cell or solid organ transplant

Treatment with systemic immunosuppressive medications within 2 weeks prior to initiation of study treatment or anticipation of need for systemic immunosuppressive medication during the study

John Muir Health Clinical Research Center

Concord, California 94520, United States

Cedars-Sinai Medical Center

Los Angeles, California 90048, United States

Martin-O?Neil Cancer Center

St. Helena, California 94574, United States

Baptist - MD Anderson Cancer Center

Jacksonville, Florida 32207, United States

Advocate Illinois Masonic Outpatient Center for Advanced Care

Chicago, Illinois 60657, United States

Des Moines Oncology Research Association

Des Moines, Iowa 50309, United States

Cancer Center of Kansas

Wichita, Kansas 67214-3728, United States

University of Maryland Greenebaum Comprehensive Cancer Center

Baltimore, Maryland 21201, United States

Fairview Southdale Medical Oncology Clinic

Edina, Minnesota 55435, United States

HCA Midwest Division

Kansas City, Missouri 64132, United States

New Hampshire Hematology Oncology

Manchester, New Hampshire 03103, United States

Monter Cancer Center

Lake Success, New York 11042, United States

Memorial Sloan Kettering Cancer Center

New York, New York 11101, United States

Rochester General Hospital; Lipson Cancer and Blood Center

Rochester, New York 14621, United States

SCRI

Nashville, Tennessee 37203, United States

Intermountain Precision Genomics Cancer Research Clinic-Dixie

St. George, Utah 84770, United States

St. Mary's Medical Center

Huntington, West Virginia 25702, United States

Centro de Oncologia e; Investigacion Buenos Aires - COIBA

Berazategui, B1880BBF, Argentina

INSTITUTO DE INVESTIGACIONES METABOLICAS (IDIM); Oncology

Ciudad Autonoma Buenos Aires, C1012AAR, Argentina

Hospital Britanico de Buenos Aires

Ciudad Autonoma Buenos Aires, C1284AEB, Argentina

Clinica Universitaria Reina Fabiola

Córdoba, X5004FHP, Argentina

Centro Oncologico Riojano Integral (CORI)

La Rioja, F5300COE, Argentina

Instituto de Oncología de Rosario

Rosario, S2000KZE, Argentina

Centro Medico San Roque

San Miguel de Tucumán, T4000IAK, Argentina

Fundación Ars Medica

San Salvador de Jujuy, Argentina

Centro de Investigacion Clinica - Clinica Viedma S.A.; Oncology Department

Viedma, R8500ACE, Argentina

St Vincent's Hospital Sydney

Darlinghurst, New South Wales 2010, Australia

Lismore Base Hospital

Lismore, New South Wales 2480, Australia

Macquarie University Hospital

Macquarie Park, New South Wales 2113, Australia

Sydney Adventist Hospital

Wahroonga, New South Wales 2076, Australia

Icon Cancer Care Wesley

Auchenflower, Queensland 4066, Australia

Icon Cancer Foundation; Icon Cancer Care Chermside

Chermside, Queensland 4032, Australia

Icon Cancer Care South Brisbane

South Brisbane, Queensland 4101, Australia

Mater Hospital; Cancer Services

South Brisbane, Queensland 4101, Australia

Icon Cancer Foundation; Icon Cancer Care Southport

Southport, Queensland 4215, Australia

Princess Alexandra Hospital; Cancer Trials Unit

Woolloongabba, Queensland 4102, Australia

Royal Adelaide Hospital; Cancer Centre

Adelaide, South Australia 5000, Australia

Ashford Cancer Center Research

Kurralta Park, South Australia 5037, Australia

Monash Medical Centre

Clayton, Victoria 3168, Australia

Austin Hospital Olivia Newton John Cancer Centre

Heidelberg, Victoria 3084, Australia

Maroondah Hospital; Breast Clinic

Ringwood East, Victoria 3135, Australia

Medical University Innsbruck; Frauenklinik Innsbruck, Dept Gyn

Innsbruck, 6020, Austria

Ordensklinikum Linz Barmherzige Schwestern; Interne 1 - Hämato-Onkologie

Linz, 4010, Austria

Uniklinikum Salzburg, LKH; Univ.Klinik f. Innere Medizin III der PMU

Salzburg, 5020, Austria

AKH - Medizinische Universität Wien; Department of Oncology

Vienna, 1090, Austria

Medizinische Universität Wien; Univ.Klinik für Frauenheilkunde - Klinik für Gynäkologie

Vienna, 1090, Austria

Salzkammergut-Klinikum Voecklabruck

Vöcklabruck, 4840, Austria

Klinikum Kreuzschwestern Wels; Iv. Interne Abt.

Wels, 4600, Austria

AZ KLINA

Brasschaat, 2930, Belgium

Institut Jules Bordet

Brussels, 1000, Belgium

UZ Leuven Gasthuisberg

Leuven, 3000, Belgium

CHC MontLégia

Liège, 4000, Belgium

Chr de La Citadelle

Liège, 4000, Belgium

CHU Ambroise Paré

Mons, 7000, Belgium

Clinique Sainte-Elisabeth; Oncologie

Namur, 5000, Belgium

Vitaz

Sint-Niklaas, 9100, Belgium

Crio - Centro Regional Integrado de Oncologia

Fortaleza, Ceará 60336-232, Brazil

Nucleo de Oncologia da Bahia - NOB

Salvador, Bahia, Estado de Bahia 40170-380, Brazil

Instituto Nacional de Cancer - INCa; Oncologia

Rio de Janeiro, Rio de Janeiro 20560-120, Brazil

Hospital Jardim Amália

Volta Redonda, Rio de Janeiro 27251-260, Brazil

Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda

Ijuí, Rio Grande do Sul 98700-000, Brazil

Hospital Moinhos de Vento

Porto Alegre, Rio Grande do Sul 90035-001, Brazil

Hospital das Clinicas - UFRGS

Porto Alegre, Rio Grande do Sul 90035-903, Brazil

Hospital Mae de Deus

Porto Alegre, Rio Grande do Sul 90110-000, Brazil

Clinica de Neoplasias Litoral

Itajaí, Santa Catarina 88301-220, Brazil

Hospital de Cancer de Barretos

Barretos, São Paulo 14784-400, Brazil

Hospital Amaral Carvalho

Jaú, São Paulo 17210-080, Brazil

Faculdade de Medicina do ABC - FMABC

Santo André, São Paulo 09060-650, Brazil

Instituto Do Câncer Do Estado de São Paulo Octávio Frias de Oliveira

São Paulo, São Paulo 01246 000, Brazil

Instituto Brasileiro de Controle Do Câncer ? São Camilo Oncologia

São Paulo, São Paulo 04014-002, Brazil

Peking University People's Hospital

Beijing, 100044, China

Beijing Hospital; Internal Medicine-Oncology

Beijing, 100730, China

Beijing Union Hospital

Beijing, 100730, China

The First Hospital of Jilin University

Changchun, 130021, China

Jilin Cancer Hospital

Changchun, 132013, China

West China Hospital, Sichuan University

Chengdu, 610041, China

Chongqing Cancer Hospital

Chongqing, 400030, China

The 900th Hospital of PLA joint service support force

Fuzhou, 110016, China

Fujian Medical University Union Hospital

Fuzhou, 350001, China

Sun yat-sen University Cancer Center; Internal Medicine of Oncology

Guangzhou, 510060, China

Guangdong General Hospital

Guangzhou, 510080, China

Sun Yat-Sen University Cancer Center - Huangpu Campus

Guangzhou, China

The First Affiliated Hospital of College of Medicine, Zhejiang University

Hangzhou, 310003, China

The Second Affiliated Hospital of Zhejiang University College

Hangzhou, 310009, China

Harbin Medical University Cancer Hospital

Harbin, 150081, China

Shandong Cancer Hospital

Jinan, 250117, China

Luoyang Central Hospital

Luoyang, 471000, China

Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School

Nanjing, 210008, China

Shanghai Jiao Tong University School of Medicine (SJTUSM) - Ruijin Hospital (GuangCi Hospital)

Shanghai, 200025, China

Zhongshan Hospital Fudan University

Shanghai, 200032, China

Fudan University Shanghai Cancer Center

Shanghai, 200120, China

The University of Hong Kong-Shenzhen Hospital; Local Ethic Committee

Shenzhen, 518053, China

Hebei Medical University Fourth Hospital;(Tumor Hospital of Hebei Province)

Shijiazhuang, 050035, China

Wuhan Union Hospital Tongji Medical College, Huazhong University of Science and Technology

Wuhan, 430022, China

Hubei Cancer Hospital

Wuhan, 430079, China

The First Affiliated Hospital of Xian Jiao Tong University

Xi'an, 710061, China

Zhejiang Cancer Hospital

Zhejiang, 310022, China

Henan Cancer Hospital

Zhengzhou, 450008, China

Nemocnice Horovice, NH Hospital a.s.; Oncology Department

Hořovice, 26831, Czechia

Fakultni Poliklinika Vseobecne Fakultni Niemocnice; Onkologicka Klinika

Prague, 128 08, Czechia

Krajska nemocnice T. Bati, a.s.

Zlín, 76001, Czechia

Herlev Hospital; Afdeling for Kræftbehandling

Herlev, 2730, Denmark

Odense Universitetshospital, Onkologisk Afdeling, Klinisk Forsknings Enhed

Odense C, 5000, Denmark

Sygehus Lillebælt, Vejle

Vejle, 7100, Denmark

Centre Hospitalier Regional Metz-Thionville - Hopital de Mercy

Ars-Laquenexy, 57530, France

Institut Sainte Catherine

Avignon, 84082, France

CH de Beauvais

Beauvais, 60000, France

CHU Jean Minjoz

Besançon, 25030, France

Clinique Tivoli; Sce Radiotherapie

Bordeaux, 33000, France

Polyclinique Bordeaux Nord Aquitaine

Bordeaux, 33300, France

Centre Hospitalier Fleyriat

Bourg-en-Bresse, 01012, France

CHRU De Brest - Hopital Morvan - Institut De Cancerologie Et D'Hematologie

Brest, 29609, France

CRLCC-Francois Baclesse; Oncologie Médicale

Caen, 14076, France

CH de Cholet; oncologie

Cholet, 49325, France

Centre Hospitalier de Compiegne

Compiègne, 60321, France

Centre Hospitalier Alpes Leman

Contamine-sur-Arve, 74130, France

Centre Georges Francois Leclerc

Dijon, 21000, France

Centre Hospitalier Departemental de Vendee

La Roche-sur-Yon, 85925, France

Clinique Chenieux; Oncology

Limoges, 87039, France

Centre Hospitalier Bretagne Sud

Lorient, 56100, France

Hopital Prive Jean Mermoz

Lyon, 69008, France

Hôpital Saint Joseph

Marseille, 13008, France

Clinique Clémentville

Montpellier, 34070, France

Institut régional du Cancer Montpellier

Montpellier, 34298, France

l'Hôpital privé du Confluent SAS

Nantes, 44202, France

Centre Antoine Lacassagne

Nice, 06189, France

CH Annecy Genevois site Annecy; Oncologie

Pringy, 74374, France

Chi De Cornouaille; Oncologie Hospitalisation

Quimper, 29107, France

Institut Jean Godinot

Reims, 51056, France

Institut du Cancer Coulancy Reims

Reims, 51100, France

Centre Henri Becquerel

Rouen, 76038, France

Institut De Cancerologie Lucien Newrth

Saint-Priest-en-Jarez, 42271, France

Centre Paul Strauss

Strasbourg, 67000, France

Hopitaux Du Leman - Site Georges Pianta

Thonon-les-Bains, 74200, France

Institut Claudius Régaud

Toulouse, 31059, France

CHU Tours - Hôpital Bretonneau

Tours, 37044, France

Hopital Prive Drome Ardeche; Hopital De Jour

Valence, 26000, France

Institut de Cancérologie de Lorraine

Vandœuvre-lès-Nancy, 54519, France

Institut Gustave Roussy; Departement Oncologie Medicale

Villejuif, 94805, France

Studienzentrum Berlin City

Berlin, 14169, Germany

St. Elisabeth-Krankenhaus

Cologne, 50935, Germany

St. Johannes-Hospital

Dortmund, 44137, Germany

Onkozentrum Dres. Göhler

Dresden, 01127, Germany

BAG Freiberg-Richter, Jacobasch, Illmer, Wolf; Gemeinschaftspraxis Hämatologie-Onkologie

Dresden, 01307, Germany

Praxis für Hamatologie und Onkologie

Erfurt, 99085, Germany

Onkodok GmbH

Gütersloh, 33332, Germany

Albertinen-Krankenhaus Klinik f.Gynäkologie und Geburtshilfe

Hamburg, 22457, Germany

Ärztehaus am Bahnhofsplatz; Praxis Uleer/Pourfard

Hildesheim, 31134, Germany

ViDia Christliche Kliniken Karlsruhe, Vincentius-Diakonissen-Kliniken gAG; Frauenklinik

Karlsruhe, 76135, Germany

Klinikum Ludwigsburg; Studiensekretariat

Ludwigsburg, 71640, Germany

St. Vincenz-Elisabeth-Hospital; Katholisches Klinikum Mainz

Mainz, 55131, Germany

Universitätsmedizin Mainz; Klinik u. Poliklinik f. Geburtshilfe u. Frauenheilkunde

Mainz, 55131, Germany

Dres. Michael Maasberg Marion Schmitz und Maria Theresia Keller

Mayen, 56727, Germany

Klinikum Memmingen; Abt.Gynäkologie

Memmingen, 87700, Germany

Johannes Wesling Klinikum Minden; Hämatologie, Onkologie, Hämostaseologie und Palliativmedizin

Minden, 32429, Germany

Brustzentrum Rhein-Ruhr Servicegesellschaft mbH

Mönchengladbach, 41061, Germany

Klinikum der Universität München; Frauenklinik - Onkologie II

München, 80336, Germany

Klinikum Neumarkt; Frauenklinik

Neumarkt in der Oberpfalz, 92318, Germany

Sana Klinikum Offenbach GmbH; Klinik für Gynäkologie & Geburtshilfe

Offenbach, 63069, Germany

Johanniter Frauenklinik Stendal Germany

Stendal, 39676, Germany

Gynäkologie Kompetenzzentrum; Praxis Dr. med. Carsten Hielscher

Stralsund, 18439, Germany

Universitätsklinik Tübingen; Frauenklinik

Tübingen, 72076, Germany

GRN-Klinik Weinheim; Abt.Gynäkologie und Geburtshilfe

Weinheim, 69469, Germany

Marien-Hospital Witten, MVZ Witten

Witten, 58452, Germany

Klinikum Worms; Frauenklinik; Klinik für Gynäkologie und Geburtshilfe

Worms, 67550, Germany

Queen Mary Hospital

Hong Kong, 999077, Hong Kong

Pamela Youde Nethersole Eastern Hospital; Clinical Oncology

Hong Kong, Hong Kong

Queen Elizabeth Hospital Department of Clinical Oncology

Kowloon, Hong Kong

National Institute of Oncology, A Dept of Internal Medicine

Budapest, 1122, Hungary

Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház

Miskolc, 3526, Hungary

Pécsi Tudományegyetem; Klinikai Központ Onkoterápiás Intézet

Pécs, 7623, Hungary

Mater Misecordiae University Hospital

Dublin, 7, Ireland

Beaumont Hospital; Cancer Clinical Trials Unit

Dublin, 9, Ireland

Shaare Zedek Medical Center

Jerusalem, 9103102, Israel

Hadassah Med Org Kiryat; Oncology Institute

Jerusalem, 9112000, Israel

Meir Medical center, Pediatrics

Kfar Saba, 4428164, Israel

Rabin MC; Davidof Center - Oncology Institute

Petah Tikva, 4941492, Israel

The Chaim Sheba Medical Center

Ramat Gan, 5211401, Israel

Azienda Ospedaliera Papa Giovanni XXIII

Bergamo, Abruzzo 24060, Italy

Azienda Ospedaliero Universitaria Di Bologna - Policlinico S.Orsola Malpighi; UO Farmacia Clinica

Bologna, Emilia-Romagna 40138, Italy

U.O Medicina Oncologica Ospedale di Carpi

Carpi, Emilia-Romagna 41012, Italy

Ospedale Degli Infermi - Faenza; Oncologia Medica

Faenza, Emilia-Romagna 48018, Italy

Azienda Ospedaliero - Universitaria di Modena Policlinico

Modena, Emilia-Romagna 41110, Italy

Azienda Ospedaliero Universitaria di Parma

Parma, Emilia-Romagna 43126, Italy

Ospedale degli Infermi

Rimini, Emilia-Romagna 47923, Italy

A.O. Universitaria S. Maria Della Misericordia Di Udine; Oncologia

Udine, Friuli Venezia Giulia 33100, Italy

Policlinico Universitario Campus Biomedico Di Roma

Rome, Lazio 00128, Italy

Azienda Ospedaliero Universitaria San Martino

Genoa, Liguria 16132, Italy

ASST DI LECCO; Oncologia Medica

Lecco, Lombardy 23900, Italy

Ospedale Mater Salutis

Legnago (VR), Lombardy 37045, Italy

Istituto Europeo Di Oncologia

Milan, Lombardy 20141, Italy

Fondazione Salvatore Maugeri

Pavia, Lombardy 27100, Italy

Policlinico San Mattea

Pavia, Lombardy 27100, Italy

Istituto Clinico Humanitas

Rozzano (MI), Lombardy 20089, Italy

Azienda Ospedaliera SS. Antonio E. Biagio E. Cesare Arrigo di Alessandria

Alessandria, Piedmont 15121, Italy

Ospedale Degli Infermi Di Biella; Reparto Oncologia Medica

Ponderano (BI), Piedmont 13875, Italy

Ospedale Santa Maria Annunziata; Oncologia

Bagno a Ripoli, Tuscany 50012, Italy

Azienda Usl 7; Dept. Oncologico

Poggibonsi, Tuscany 53036, Italy

Nuovo Ospedale Di Prato

Prato, Tuscany 50047, Italy

Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia

Perugia, Umbria 06100, Italy

Aichi Cancer Center Hospital

Aichi, 464-8681, Japan

Chiba Cancer Center

Chiba, 260-8717, Japan

Shikoku Cancer Center

Ehime, 791-0280, Japan

National Hospital Organization Kyushu Cancer Center

Fukuoka, 811-1395, Japan

Hiroshima City Hiroshima Citizens Hospital

Hiroshima, 730-8518, Japan

National Hospital Organization Hokkaido Cancer Center

Hokkaido, 003-0804, Japan

Hyogo Medical University Hospital

Hyōgo, 663-8501, Japan

University of Tsukuba Hospital

Ibaraki, 305-8576, Japan

Sagara Hospital

Kagoshima, 892-0833, Japan

Kanagawa Cancer Center

Kanagawa, 241-8515, Japan

Tokai University Hospital

Kanagawa, 259-1193, Japan

Kyoto University Hospital

Kyoto, 606-8507, Japan

Fukushima Medical University Hospital

Miyagi, 960-1295, Japan

Okayama University Hospital

Okayama, 700-8558, Japan

Naha-nishi Clinic

Okinawa, 901-0154, Japan

National Hospital Organization Osaka National Hospital

Osaka, 540-0006, Japan

Osaka International Cancer Institute

Osaka, 541-8567, Japan

Saitama Medical University International Medical Center

Saitama, 350-1298, Japan

Saitama Cancer Center

Saitama, 362-0806, Japan

Shizuoka Cancer Center

Shizuoka, 411-8777, Japan

St. Luke's Internat. Hospital, Breast Surgical Oncology

Tokyo, 104-8560, Japan

The Cancer Institute Hospital of JFCR

Tokyo, 135-8550, Japan

Iem-Fucam

D.F., Mexico CITY (federal District) 04980, Mexico

Instituto Nacional De Cancerologia; Oncology; Tumores Mamarios

Distrito Federal, Mexico CITY (federal District) 14000, Mexico

Health Pharma Professional Research

Mexico City, Mexico CITY (federal District) 03100, Mexico

Centro Médico Zambrano Hellion

Monterrey, Nuevo León 66278, Mexico

Centro de Investigacion Clinica de Oaxaca

Oaxaca City, Oaxaca 68020, Mexico

Oncologico Potosino

San Luis Potosí City, San Luis Potosí 78209, Mexico

Merida | Investigacion Clinica

Mérida, Yucatán 97125, Mexico

CENEIT Oncologicos; DENTRO DE CONDOMINIO SAN FRANCISCO

Mexico City, 03100, Mexico

Centro Medico Dalinde

Mexico City, 06700, Mexico

Hospital Nacional Carlos Alberto Seguin Escobedo-Essalud; Oncology & Haemathology

Arequipa, 04001, Peru

Instituto Nacional de Enfermedades Neoplasicas

Lima, 15038, Peru

Oncosalud Sac; Oncología

Lima, 41, Peru

Instytut MSF Sp. z o.o.

?ód?, 90-302, Poland

MedPolonia

Poznan, 60-693, Poland

Wielkopolskie Centrum Onkologi

Poznan, 61-866, Poland

Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy; Klinika Onkologii

Warsaw, 00-909, Poland

"Filantropia" Clinical Hospital; Gynecological Oncology

Bucharest, 011191, Romania

Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca; Oncologie Medicala

Cluj-Napoca, 400015, Romania

Centrul de Oncologie Sfantul Nectarie

Craiova, 200347, Romania

Medsi Clinic

Moscow, Adygeya Republic 143442, Russia

Arkhangelsk Regional Clinical Oncology Dispensary

Arkhangelsk, Arhangelsk 163045, Russia

Bashkirian Republican Clinical Oncology Dispensary

Ufa, Bashkortostan Republic 450054, Russia

Oncologica Dispensary #2

Sochi, Krasnodarskiy Kray 354057, Russia

Evimed

Chelyabinsk, Kurgan Oblast, Russia

Moscow Clinical Scientific Center

Moscow, Moscow Oblast 111123, Russia

FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF

Moscow, Moscow Oblast 115478, Russia

P.A. Herzen Oncological Inst. ; Oncology

Moscow, Moscow Oblast 125248, Russia

Nizhny Novgorod Regional Clinical Oncology Center

Nizhny Novgorod, Niznij Novgorod 603126, Russia

Mordovia State University

Saransk, Respublika Mordoviya 430032, Russia

National Medical Research Center for Oncology

Rostov-on-Don, Rostov Oblast 344037, Russia

LLC Strategic Medical Systems

Saint Petersburg, Sankt-Peterburg 194291, Russia

EosMed LLC

Saint Petersburg, Sankt-Peterburg 195197, Russia

Private Healthcare Institution Clinical Hospital RZhD Medicine

Saint Petersburg, Sankt-Peterburg 195271, Russia

LCC Center of Palliative Medicine - Devita

Saint Petersburg, Sankt-Peterburg 197343, Russia

S-Pb clinical scientific practical center of specialized kinds of medical care (oncological)

Saint Petersburg, Sankt-Peterburg 197758, Russia

FBI "Scientific Research Institute of Oncology n. a. N. N. Petrov"

Saint Petersburg, Sankt-Peterburg, Russia

Pyatigorsky Oncologic Dispensary

Pyatigorsk, Stavropol Kray 357524, Russia

Regional Clinical Oncology Hospital

Yaroslavl, Yaroslavl Oblast 150054, Russia

Regional Oncology Hospital

Irkutsk, 664035, Russia

Ivanovo Regional Oncology Dispensary

Ivanovo, 153040, Russia

Regional Oncology Dispensary; Dept of Chemotherapy

Novgorod Veliky, 173016, Russia

BIH at Omsk Region "Clinical Oncology Dispensary", Outpatient clinic

Omsk, 644013, Russia

Multidisciplinary clinic Reaviz

Samara, 443011, Russia

Samara Regional Oncology Dispensary

Samara, 443031, Russia

Regional Clinical Hospital

Saratov, 410053, Russia

SHI Volgograd Regional Clinical Oncological Dispensary#1

Volgograd, 400138, Russia

National University Hospital; Medical Oncology

Singapore, 119074, Singapore

National Cancer Centre

Singapore, 169610, Singapore

Chungbuk National University Hospital

Cheongju-si, 28644, South Korea

Soon Chun Hyang University Cheonan Hospital

Dongnam-gu, Cheonan-si, 31151, South Korea

National Cancer Center

Goyang-si, 10408, South Korea

CHA Bundang Medical Center

Gyeonggi-do, 13496, South Korea

Gachon University Gil Medical Center

Incheon, 21565, South Korea

Inha University Hospital

Incheon, 22332, South Korea

Seoul National University Bundang Hospital

Seongnam-si, 463-707, South Korea

Seoul National University Hospital

Seoul, 03080, South Korea

Severance Hospital; Yonsei University Health System

Seoul, 03722, South Korea

Asan Medical Center

Seoul, 05505, South Korea

Gangnam Severance Hospital

Seoul, 06273, South Korea

Samsung Medical Center

Seoul, 06351, South Korea

Seoul St Mary's Hospital

Seoul, 06591, South Korea

Ewha Womans University Mokdong Hospital

Seoul, 07985, South Korea

Ajou University Hospital

Suwon, 443-721, South Korea

Ulsan University Hosiptal

Ulsan, 44033, South Korea

Wonju Christian Hospital

Wŏnju, 220-701, South Korea

Hospital Son Llatzer

Palma de Mallorca, Balearic Islands 07198, Spain

Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia

Badalona, Barcelona 08916, Spain

Hospital General De Catalunya; Servicio de Oncologia

Sant Cugat del Vallès, Barcelona 28981, Spain

Consorci Hospitalari de Terrassa

Terrassa, Barcelona 08227, Spain

Hospital de Jerez

Jerez de la Frontera, Cadiz 11407, Spain

Hospital Provincial Castellón

Castellon de LA Plana/castello de LA Plana, Castellon 12002, Spain

Centro Oncologico de Galicia COG; Medical Oncology

A Coruña, LA Coruña 15009, Spain

Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia

Santiago de Compostela, LA Coruña 15706, Spain

Hospital Universitario Puerta de Hierro - Majadahonda

Majadahonda, Madrid 28220, Spain

Hospital Infanta Sofia; Servico de Oncologia

San Sebastián de los Reyes, Madrid 28702, Spain

Complexo Hospitalario de Vigo. Hospital Álvaro Cunqueiro; Servicio de Oncología

Vigo, Pontevedra 36312, Spain

Hospital Universitari Sant Joan de Reus; Planta baja, color lila

Reus, Tarragona 43204, Spain

Hospital Universitario de Canarias;servicio de Oncologia

San Cristóbal de La Laguna, Tenerife 38320, Spain

Hospital Universitario de Burgos

Burgos, 09006, Spain

Hospital San Pedro De Alcantara; Servicio de Oncologia

Cáceres, 10003, Spain

Complejo Hospitalario de Jaen

Jaén, 23007, Spain

Complejo Asistencial Universitario de Leon; Servicio de Oncologia

León, 24071, Spain

Hospital General Universitario Gregorio Marañon; Servicio de Oncologia

Madrid, 28009, Spain

Hospital Universitario Ramón y Cajal

Madrid, 28034, Spain

Hospital Universitario 12 de Octubre; Servicio de Oncologia

Madrid, 28041, Spain

Centro Integral Oncológico Clara Campal Ensayos Clínicos START

Madrid, 28050, Spain

Hosp Univ Fundacion Alcorcon

Madrid, 28922, Spain

Hospital Universitario de Fuenlabrada; Servicio de Oncologia

Madrid, 28943, Spain

Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia

Málaga, 29010, Spain

Hospital Universitario Virgen de Arrixaca; Servicio de Oncologia

Murcia, 30120, Spain

Hospital Quirón Sagrado Corazón

Seville, 41013, Spain

Instituto Valenciano Oncologia; Oncologia Medica

Valencia, 46009, Spain

Hospital Clinico Universitario de Valencia

Valencia, 46010, Spain

Hospital General Universitario de Valencia; Servicio de oncologia

Valencia, 46014, Spain

Hospital Clinico Universitario Lozano Blesa; Servicio de Oncologia

Zaragoza, 50009, Spain

Hirslanden Medical Center - Tumorzentrum

Aarau, 5000, Switzerland

Centre Hospitalier Universitaire Vaudois - Lausanne

Lausanne, 1011, Switzerland

Brust-Zentrum Zürich AG Seefeldstrasse 214 Zürich

Zurich, 8008, Switzerland

Chunghua Christian hospital

Changhua, 500, Taiwan

Kaohsiung Medical University Hospital; Chung-Ho Memorial Hospital

Kaoshiung City, 807, Taiwan

E-Da Cancer Hospital; Hematology- Oncology Department

Kaoshiung, 824, Taiwan

Chi Mei Medical Center Liou Ying Campus

Liuying Township, 736, Taiwan

National Cheng Kung University Hospital

Tainan, 70457, Taiwan

National Taiwan University Hospital

Taipei, 10002, Taiwan

Mackay Memorial Hospital - Taipei Branch

Taipei, 104, Taiwan

Taipei Veterans General Hospital

Taipei, 112, Taiwan

Tri-Service General Hospital

Taipei, 11490, Taiwan

Chang Gung Medical Foundation Linkou Branch

Taoyuan City, 333, Taiwan

Rajavithi Hospital; Division of Medical Oncology

Bangkok, 10400, Thailand

Ramathibodi Hospital; Medicine/Oncology

Bangkok, 10400, Thailand

Siriraj Hospital; Clinical Research Center, Pharmacy Department

Bangkok, 10700, Thailand

Songklanagarind Hospital

Hat Yai, 90110, Thailand

Srinagarind Hospital, Khon Kaen University

Khon Kaen, 40002, Thailand

Lampang Cancer Hospital

Lampang, 52000, Thailand

King Chulalongkorn Memorial Hospital; Faculty of Medicine Chulalongkorn University

Patumwan, 10330, Thailand

Baskent Universitesi Adana Dr. Turgut Noyan Uygulama ve Arastirma Merkezi

Adana, 01240, Turkey (Türkiye)

Uludag Universitesi - Saglik Uygulama ve Arastirrma Merkezi

Bursa, 16059, Turkey (Türkiye)

Izmir Ekonomi Universitesi Medical Park Hastanesi

Izmir, 35575, Turkey (Türkiye)

Mersin Universitesi Tip Fakultesi Hastanesi; Tibbi Onkoloji Birimi

Mersin, 33110, Turkey (Türkiye)

Medikal Park Samsun

Samsun, 55200, Turkey (Türkiye)

Yulis Medical and Diagnostic Center

Zaporizhzhya, Katerynoslav Governorate 69061, Ukraine

MI "Clinical Oncological Dispensary" of Dnipro Reg Council; chemotherapy department

Dnipro, KIEV Governorate 49100, Ukraine

Municipal Institution Odesa Regional Oncology Dispensary

Odesa, KIEV Governorate 65055, Ukraine

Vinnytsya Regional Clinical Oncology Dispensary

Vinnytsia, Podolia Governorate 21029, Ukraine

Regional Oncology Center; Department of Mammology

Chernihiv, 14029, Ukraine

Chernivtsi Regional Clinical Oncology Dispensary

Chernivtsi, 58013, Ukraine

City Clinical Hospital #4

Dnipropetrovsk, 49102, Ukraine

Municipal Institution Kirovograd Regional Oncology Dispensary

Kirovograd, 25011, Ukraine

ME Kryviy Rih Oncology Dispensary of Dnipropetrovs?k Regional Council; Chemotherapy Department

Kryvyi Rih, 50048, Ukraine

Volyn Regional Oncology Dispensary

Lutsk, 43018, Ukraine

Lviv State Oncological Regional Treatment and Diagnostic Center

Lviv, 79031, Ukraine

Municipal Institution Odesa Regional Clinical Hospital

Odesa, 65025, Ukraine

Sumy Reg. Clin. Oncological Dispensary; Thoracall Department

Sumy, 40005, Ukraine

CCCH City Oncological Center SHEI Uzhgorod NU

Uzhhorod, 88000, Ukraine

Transkarpathian Regional Oncology Clinic; Chemotherapy

Uzhhorod, 88000, Ukraine

Zaporizhzhia Regional Clinical Oncology Dispensary; Zaporizhzhya State Medical University

Zaporizhzhya, 69040, Ukraine

NHS Lothian - Western General Hospital; NHS Lothian - Western General Hospital

Edinburgh, EH4 2XU, United Kingdom

Calderdale and Huddersfield NHS Foundation Trust

Huddersfield, HD3 3EA, United Kingdom

Leeds Teaching Hosp NHS Trust;St James's Institute of Onc

Leeds, LS9 7TF, United Kingdom

The Christie NHS Foundation Trust

Manchester, M20 4BX, United Kingdom

Nottingham University Hospitals NHS Trust - City Hospital

Nottingham, NG5 1PB, United Kingdom

University Hospitals of North Midlands NHS Trust-Royal Stoke University Hospital

Stoke-on-Trent, ST4 6QG, United Kingdom