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Multiple Sclerosis (MS) is inflammatory, demyelinating and autoimmune disease of the central nervous system. It is usually seen with relapses and genetic and environmental factors play a role in the etiology. Neurological symptoms seen in MS restrict the patient's daily activity and social role participation. Mobility problems and fatigue are the most important reasons of role limitations and decreased quality of life. The importance of exercise training in disease management has been emphasized in recent years. However, few studies have investigated the effects of task-oriented trainings on symptoms of the disease. The aim of this sudy is to investigate the effects of task-oriented training additional to combined exercise training on functional capacity, mobility, balance, fatigue and quality of life in patients with MS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | Active Comparator | Patients in this group will receive combined exercise training included aerobic and strengthening exercises, 3 times a week for 6 weeks. All exercise sessions will be performed under the supervision of a physiotherapist. |
|
| Training group | Experimental | Patients in this group will receive task-oriented training additional to combined exercise training 3 times a week for 6 weeks. Task-oriented training included more functional daily life mobility activities like reaching, obstacle walking, stairs climbing. All exercise sessions will be performed under the supervision of a physiotherapist. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Combined exercise training | Other | Aerobic training with cycle ergometer %60-80 of maximal Heart Rate, submaximal level, strengthening of the major muscles of upper and lower extremities |
| Measure | Description | Time Frame |
|---|---|---|
| Functional capacity | Change from baseline functional capacity with six minute walking test | 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| dynamic gait skills | Change from baseline functional mobility with dynamic gait index | 6 weeks |
| limitation of gait | Change from baseline functional mobility with MS walking scale-12 |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D020529 | Multiple Sclerosis, Relapsing-Remitting |
| D005221 | Fatigue |
| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
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| Task-oriented training | Other | Functional reaching, walking on different obstacles and floor,sitting and standing on different levels and surface,walking around obstacle, climbing stairs with different height and surface |
|
| 6 weeks |
| dynamic balance and fall risk | Change from baseline functional mobility with timed up and go test | 6 weeks |
| sitatic balance | Change from baseline balance with functional reach test | 6 weeks |
| dynamic balance | Change from baseline balance with berg balance scale | 6 weeks |
| severity of fatigue | Change from baseline fatigue with fatigue severity scale | 6 weeks |
| impact of fatigue | Change from baseline fatigue with fatigue impact scale | 6 weeks |
| Quality of life | Change from baseline quality of life with MS quality of life instrument-54 | 6 weeks |
| D003711 | Demyelinating Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |