BCVA was assessed for both eyes using the ETDRS visual acuity (VA) chart. BCVA test should be performed prior to pupil dilation, and distance refraction should be carried out before BCVA is measured. Initially, letters are read at a distance of 4 meters from the chart. If <20 letters are read at 4 meters, testing at 1 meter should be performed. The lower the number of letters read correctly on the eye chart, the worse the vision (or VA). Percentage of participants with a ≥15 -letter improvement from baseline in BCVA at Month 12 was reported for both eyes.

Intent-to-treat (ITT) population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement.

BCVA was assessed for study eye using the ETDRS VA chart. BCVA test should be performed prior to pupil dilation, and distance refraction should be carried out before BCVA is measured. Initially, letters are read at a distance of 4 meters from the chart. If <20 letters are read at 4 meters, testing at 1 meter should be performed. BCVA was reported as number of letters read correctly by the participant using the ETDRS Scale (ranging from 0 to 100 letters) in the study eye. The lower the number of letters read correctly on the eye chart, the worse the vision (or VA). An increase in the number of letters read correctly means that vision has improved. Here negative values indicate decline in BCVA.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement.

BCVA was assessed for both eyes using the ETDRS VA chart. BCVA test should be performed prior to pupil dilation, and distance refraction should be carried out before BCVA is measured. Initially, letters are read at a distance of 4 meters from the chart. If <20 letters are read at 4 meters, testing at 1 meter should be performed. The lower the number of letters read correctly on the eye chart, the worse the vision (or VA). Percentage of participants with a ≥10 -letter improvement from baseline in BCVA at Month 12 was reported for both eyes.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement.

BCVA was assessed for both eyes using the ETDRS VA chart. BCVA test should be performed prior to pupil dilation, and distance refraction should be carried out before BCVA is measured. Initially, letters are read at a distance of 4 meters from the chart. If <20 letters are read at 4 meters, testing at 1 meter should be performed. The lower the number of letters read correctly on the eye chart, the worse the vision (or VA). Percentage of participants with no decrease or a decrease of <5 letters from baseline in BCVA at Month 12 was reported for both eyes.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement.

BCVA was assessed for both eyes using the ETDRS VA chart. BCVA test should be performed prior to pupil dilation, and distance refraction should be carried out before BCVA is measured. Initially, letters are read at a distance of 4 meters from the chart. If <20 letters are read at 4 meters, testing at 1 meter should be performed. BCVA was reported as number of letters read correctly by the participant using the ETDRS Scale (ranging from 0 to 100 letters) in both the study and fellow eyes. The lower the number of letters read correctly on the eye chart, the worse the vision (or VA). An increase in the number of letters read correctly means that vision has improved. Here negative values indicate decline in BCVA.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis. 'Number analyzed' indicates the number of participants with data available for analysis at the specified timepoint.

Fundus AF was used to assess change in total area of preserved AF. Areas of preserved AF were identified as well-demarcated regions of relative hyper AF compared with the background areas of surrounding atrophy. A negative change from baseline indicate decline in total area of preserved AF.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis.

Fundus AF was used to assess change in distance from foveal center (FC) to nearest border of preserved AF. A negative change from baseline indicate decline in distance from FC to nearest border of AF.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis.

SD-OCT was used to assess change in foveal subfield thickness. The measurements were taken after dilation of the participant's pupil. A negative change from baseline indicates decline in foveal subfield thickness.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis.

SD-OCT was used to assess change in total macular volume. The measurements were taken after dilation of the participant's pupil. A negative change from baseline indicates decline in total macular volume.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis.

SD-OCT was used to assess change in central horizontal ellipsoid width. The measurements were taken after dilation of the participant's pupil. A negative change from baseline indicates decline in central horizontal ellipsoid width.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis.

SD-OCT was used to assess change in central ellipsoid area. The measurements were taken after dilation of the participant's pupil. A negative change from baseline indicates decline in central ellipsoid area.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis.

SD-OCT was used to assess change in choroidal thickness. The measurements were taken after dilation of the participant's pupil. A negative change from baseline indicates decline in choroidal thickness.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis.

Microperimetry was conducted to assess change in mean retinal sensitivity within the macula. Retinal mean sensitivity to light was measured in decibels (dBs) in multiple spots across the central and peripheral retina (entire visual field). Higher numbers (dBs) indicate higher retinal sensitivity. A negative change from baseline indicates decline in retinal sensitivity.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis.

Microperimetry was conducted to assess change in bivariate contour ellipse area 63%. A negative change from baseline indicates decline in bivariate contour ellipse area 63%.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis.

Microperimetry was conducted to assess change in bivariate contour ellipse area 95%. A negative change from baseline indicates decline in bivariate contour ellipse area 95%.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis.

Change in contrast sensitivity was assessed by Pelli-Robson chart which uses a single large letter size (20/60 optotype), with contrast varying across groups of letters (6 per line), whose contrast varies from high to low. Participants read letters, starting with highest contrast, until they are unable to read 2 or 3 letters in a single group. Each group had three letters of the same contrast level, so there were three trials per contrast level. Score is assigned based on contrast of last group in which 2 or 3 letters were correctly read. Score is a measure of participant's log contrast sensitivity ranging from 0 (no letters read) to 2.25 (all letters read). Total CS score=[(total letters correct-3) x 0.05]. A negative change from baseline indicates worsening in contrast sensitivity score.

ITT population included all randomized participants who received study treatment (phone call for untreated control group) and had at least 1 post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis.

Colour vision total error scores were assessed by the Farnsworth Munsell 100 Hue Sort Test. Farnsworth Munsell 100 Hue Test requires placing 100 colour palettes in the correct order based upon colour hue. Scores are determined by the frequency and severity of any displacement in the correct order. One error equates to one misplaced hue, by one step or position. An error score of 0 indicates no errors in ordering the hues while error score greater than 500 indicates virtually no color discrimination. A Total Error Score of 0 to 128 could be seen in a normal population.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis.

The reading speed (words per minute) was calculated using the following formula: [number of words in the text - number of misread words] / reading time x 60. The number of misread words and reading time is collected. A negative change from baseline indicates decline in reading speed.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis.

VFQ-25 consists of a base set of 25 vision-targeted questions representing 11 vision-related constructs, plus an additional single-item general health rating question. All items are scored so that a high score represents better functioning. Each item is then converted to a 0 to 100 scale so that the lowest and highest possible scores are set at 0 and 100 points, respectively. A score of 0 represents the worst outcome and 100 represents the best outcome. A negative change from baseline indicates decline in VFQ-25 score.

ITT population included all randomized participants who received the study treatment (or the phone call for those in the untreated control group) and had at least one post-treatment BCVA measurement. 'Overall number of participants analyzed' indicates the number of participants with data available for outcome measure analysis.