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| Name | Class |
|---|---|
| First Affiliated Hospital of Shantou University Medical College | OTHER |
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The investigators sought to identify and verify the potential correlates and mechanisms of Very Late Stent Thrombosis (VLST) after the implantation of new generation drug eluting steng in China from an analysis of multicenter registries.
This study represents a patient-level pooled analysis of patients undergoing percutaneous coronary intervention with stent implantation for acute coronary syndrome. Multiple aspects including clinical, angiographic, procedural characteristics , intravascular imaging results and blood samples were collected at index PCI and the time of VLST or CAG during follow-up, in order to reveal the potential mechanisms or risk factors that contribute to the development of VLST.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| derivation cohort | no interventions will be administrated | ||
| validation cohort | no interventions will be administrated |
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| Measure | Description | Time Frame |
|---|---|---|
| Very Late Stent Thrombosis | very late stent thrombosis demonstrated by coronary angiography | Five years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients>18y,admitted for acute coronary syndrome,successfully underwent PCI with at least one stent, sign informed consent were included.Patients' expected lifetime was less than 1 year for any severe disease(such as tumor,severe respiratory failure et al),and with a surgical plan for important organs within 1 year after surgery and anti-platelet drugs should be discontinued, refusing to sign informed consent, died prior to discharge, unable to participate in regular follow-up were excluded.
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| Name | Affiliation | Role |
|---|---|---|
| yang zheng | Jilin University 1st Hospital Cardiovascular Center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jilin University 1st Hospital | Changchun | Jilin | 130021 | China |
When the investigation is completed,we will share it with other researchers.
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| ID | Title | Description |
|---|---|---|
| FG000 | Derivation Cohort | Patients enrolled in the study in Jilin University First Hospital, no interventions will be administrated |
| FG001 | Validation Cohort | Patiens enrolled in the study in First affiliated Hospital of Shantou University, no interventions will be administrated |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
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A total of 5185 patients (average age 59.85 ± 9.95 years, 68.60% male) from the derivation cohort and 2058 patients (average age 60.00 ± 10.22 years, 68.71% male) from the validation cohort were included in the analysis, respectively.
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| ID | Title | Description |
|---|---|---|
| BG000 | Derivation Cohort | Patients enrolled in Jilin University First Hospital, no interventions will be administrated |
| BG001 | Validation Cohort | Patients enrolled in First Affiliated Hosptal of Shantou University, no interventions will be administrated |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Very Late Stent Thrombosis | very late stent thrombosis demonstrated by coronary angiography | Posted | Count of Participants | Participants | Five years |
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five years
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Derivation Cohort | no interventions will be administrated | 316 |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Xiang Wang | First Hospital of Jilin University | +86-13504321434 | jdwxiang123@126.com |
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blood samples including serum and plasma
| BG002 | Total | Total of all reporting groups |
| years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Race and Ethnicity Not Collected | Race and Ethnicity were not collected from any participant. | Count of Participants | Participants |
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| History or Diabetes Mellitus | Number | participants |
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| Hypertension | Count of Participants | Participants |
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| Dyslipidaemia | Count of Participants | Participants |
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| Current smoker | Count of Participants | Participants |
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| History of drinking | Count of Participants | Participants |
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| History of stroke/TIA | Count of Participants | Participants |
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| History of PVD | Count of Participants | Participants |
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| History of heart failure | Count of Participants | Participants |
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| Previous CABG | Count of Participants | Participants |
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| Previous PCI | Count of Participants | Participants |
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| Previous MI | Count of Participants | Participants |
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| AMI as admitting diagnosis | Count of Participants | Participants |
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| Cardiogenic shock | Count of Participants | Participants |
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| 6,038 |
| 0 |
| 6,038 |
| 0 |
| 6,038 |
| EG001 | Validation Cohort | no interventions will be administrated | 132 | 2,438 | 0 | 2,438 | 0 | 2,438 |
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