PI was unable to continue to gather data during the trip during to medical illness

The overall goal of this study is to detect preclinical signs of HAPE by lung ultrasonography and evaluate the effectiveness of acetazolamide at decreasing pulmonary edema by using ultrasound.

Inclusion Criteria:

1. At least 18 years of age
2. Able to consent
3. English speaking
4. Trekking directly to Everest Base Camp

Exclusion Criteria:

1. Age less than 18 years
2. Non-English speaking
3. Pregnant
4. Already had a diagnosis of acute mountain sickness, high-altitude cerebral edema, or high-altitude pulmonary edema
5. Been on a high-altitude trek 2 weeks prior to this study
6. Has taken acetazolamide 1 week prior to start of trek
7. Has a sulfa allergy
8. Has any type of acute or chronic pulmonary conditions

No ipd to share.

Participants were enrolled, but no participants were randomized to intervention and no participants received intervention.

Due to investigator illness, no participants were randomized and no study drug was administered.

Due to investigator illness, no participants were randomized and no study drug was administered.

Due to Investigator illness, although participants were enrolled, no participants were randomized to receive interventions and did not receive study drug.