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Administration of antiretroviral therapy has brought benefits for infective human immunodeficiency virus-1 (HIV-1)-patients, reducing the number of AIDS-related morbidity and mortality. However, it is responsible for intensifying complications triggered by the chronic inflammatory state associated with virus infection, such as cardiovascular diseases. The current study evaluated effects of single dose (140mL) of Beetroot Juice (BJ) on macro and microvascular endothelial function in HIV-1-patients undergoing antiretroviral terapy, once BJ was shown to be effective in improving these physiological parameters in uninfected individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Beetroot juice | Active Comparator | Beetroot Juice cotaining on average 9mmol of nitrate per dose |
|
| Placebo beet juice (Nitrate depleted) | Placebo Comparator | Beetroot juice nitrate depleted |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beetroot Juice | Dietary Supplement | 140ml of Beetroot Juice containing on avarege 9 mmol of nitrate |
|
| Measure | Description | Time Frame |
|---|---|---|
| Skeletal Muscle Oxygenation | Changes in skeletal muscle oxygenation in response to exercise will be evaluated by using a near-infrared spectroscopy device. | Baseline and approximately after 150 minutes of beetroot juice consumption |
| Brachial artery flow-mediated dilatation | The brachial artery flow-mediated dilation will be evaluated by using an ultrasound device. | Baseline and approximately after 150 minutes of beetroot juice consumption |
| Measure | Description | Time Frame |
|---|---|---|
| Urinary nitrate concentrations | Analysis of nitrate in urine will be performed by using high-performance liquid chromatography system. | Baseline and approximately 30, 90, and 150 minutes after beetroot juice consumption |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| DST / AIDS and Viral Hepatitis Program of Macaé | Macaé | Rio de Janeiro | Brazil |
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| ID | Term |
|---|---|
| D000163 | Acquired Immunodeficiency Syndrome |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
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Double- Blind
| Placebo | Dietary Supplement | 140ml of Beetroot Juice (nitrate free) |
|
| D015229 |
| Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012897 | Slow Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |