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This study evaluates the optimum day of menstrual period for the excision of endometriomas to minimize the damage of surgery to normal ovarian tissue. Patients will be grouped as follicular, ovulatory and luteal according to menstrual days. Ovarian damage will be evaluated with both pathologic examination and anti-mullerian hormone levels before and after the surgery.
Endometriosis is a common gynecologic disease seen in about 10% of women in reproductive age. The most common site of endometriosis is overt. Cystic formation of ovarian endometriosis is called endometrioma (chocolate cyst). Definitive treatment of endometriomas is excision by laparoscopy. The disadvantage of this surgery is the removal of some of the normal ovarian follicles within cystectomy material. This procedure can damage the ovarian reserves with the treatment of endometriomas, which are already the cause of infertility, and lead to the conditions such as infertility or early menopause. It has been understood that the ovarian reserves of the patients who underwent endometrioma cystectomy with the decrease of the Anti-Mullerian Hormone values, which is an over reserve parameter.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| folicular | Women who will undergo endometrioma cystectomy in her follicular phase of menstrual period. |
| |
| ovulatory | Women who will undergo endometrioma cystectomy in her ovulatory phase (12-14th day of mestrual period cycle for women regular period) of menstrual cycle. |
| |
| luteal | Women who will undergo endometrioma cystectomy in her luteal phase of menstrual period. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| laparoscopic endometrioma cyst excision | Procedure | laparoscopic resection of ovarian endometrioma |
|
| Measure | Description | Time Frame |
|---|---|---|
| Determination of ovarian follicle damage via histological examination | Histologic evaluation of the cystectomy excision material for health ovarian follicles | 5 days after the surgery |
| Change of anti-mullerian hormone level 6 months after surgery | Comparison of pre-operative and 6 months after surgery of anti-mullerian hormone levels | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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Women who admitted to out-patient clinic between the ages of 18-40 years,had 4-10cm ovarian unilateral endometrioma and had an indication of laparoscopic ovarian endometrioma excision.
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| Name | Affiliation | Role |
|---|---|---|
| Ozguc Takmaz | Acibadem MAA University Maslak Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Acibadem Fulya Hospital | Istanbul | 34457 | Turkey (Türkiye) | |||
| Acibadem MAA University Atakent Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39473503 | Derived | Takmaz O, Asoglu MR, Ceyhan M, Unsal G, Gungor M. Comparing ovarian reserve parameters after laparoscopic endometrioma resection in the follicular vs. luteal phase: a prospective cohort study. Front Med (Lausanne). 2024 Oct 15;11:1469858. doi: 10.3389/fmed.2024.1469858. eCollection 2024. |
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Data sharing will be decided during the study process.
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| ID | Term |
|---|---|
| D004715 | Endometriosis |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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blood sample
| Istanbul |
| 34457 |
| Turkey (Türkiye) |
| Acibadem MAA University Maslak Hospital | Istanbul | 34457 | Turkey (Türkiye) |
| D000091662 | Genital Diseases |