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| Name | Class |
|---|---|
| Academia Sinica, Taiwan | OTHER |
| Tri-Service General Hospital (TSGH) | OTHER |
| Fu Jen Catholic University | OTHER |
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The purpose of this study is to perform dietary intervention studies on a variety of vegetables.
Plant-based foods have always been an important component of a healthy diet. High intake of plant foods may not only maintain normal bodily functions through the provision of dietary fiber, vitamins, and minerals but also relieve symptoms and prevent diseases. Many studies have pointed out that high intake of plant foods may reduce the incidence of non-communicable disease. Past research investigating the effect of phytochemicals has usually been limited to single substances or single foods. However, a number of researchers have pointed out that phytonutrients and dietary components are likely to act synergistically.Health effects and mechanisms of phytonutrients in combination have not been carefully studied in population settings. The technology of metabolomics has enabled the simultaneous measurement of hundreds of small molecules in biological samples. Exploring the change of metabolites after feeding can not only help us understand the role of plant foods, but may also provide opportunities to assess plant food intake levels.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Experimental | Participants were fed a standardized diet (without any vegetables) in this experiment. |
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| Spinach | Experimental | Participants were fed a standardized diet with 200g spinach in this experiment. |
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| Celery | Experimental | Participants were fed a standardized diet with 200g celery in this experiment. |
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| Onion | Experimental | Participants were fed a standardized diet with 200g onion in this experiment. |
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| Mixed Vegetables | Experimental | Participants were fed a standardized diet with 200g of mixed vegetables (spinach, celery, and onion) in this experiment. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control | Other | A standardized diet without any vegetables was provided. |
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| Measure | Description | Time Frame |
|---|---|---|
| Intensities of multiple serum metabolites | The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS. | Baseline (fasting state before breakfast at 7:30AM) |
| Intensities of multiple serum metabolites | The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS. | 4 Hours (immediately before lunch at 11:30AM) |
| Intensities of multiple serum metabolites | The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS. | 5.5 hours (after lunch at 13:00PM) |
| Intensities of multiple serum metabolites | The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS. | 6.5 hours (after lunch at 14:00 PM) |
| Intensities of multiple serum metabolites | The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wen-Harn Pan, Ph.D. | National Health Research Institutes, Taiwan | Principal Investigator |
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| Spinach |
| Other |
A standardized diet with 200g spinach was provided. |
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| Celery | Other | A standardized diet with 200g celery was provided. |
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| Onion | Other | A standardized diet with 200g onion was provided. |
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| Mixed Vegetables | Other | A standardized diet with 200g of mixed vegetables (spinach, celery, and onion) was provided. |
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| 7.5 hours (after lunch at 15:00PM) |
| Intensities of multiple serum metabolites | The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS. | 8.5 hours (after lunch at 16:00PM) |
| Intensities of multiple serum metabolites | The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS. | 9.5 hours (after lunch at 17:00PM) |
| Intensities of multiple serum metabolites | The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS. | 10.5 hours (after lunch at 18:00PM) |
| Intensities of multiple serum metabolites | The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS. | 11.5 hours (after lunch at 19:00PM) |
| Intensities of multiple urinary metabolites | The outcome measure consists of intensities of multiple urinary metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS. | Baseline (overnight urine sample collected at 7:30AM) |
| Intensities of multiple urinary metabolites | The outcome measure consists of intensities of multiple urinary metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS. | 3.5~4 hours (before lunch urine sample collected during 11:00~11:30AM) |
| Intensities of multiple urinary metabolites | The outcome measure consists of intensities of multiple urinary metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS. | 4.5~6.5 hours (2-hour after lunch urine sample collected from 12:00 to 14:00PM) |
| Intensities of multiple urinary metabolites | The outcome measure consists of intensities of multiple urinary metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS. | 6.5~8.5 hours (4-hour after lunch urine sample collected from 14:00 to 16:00PM) |
| Intensities of multiple urinary metabolites | The outcome measure consists of intensities of multiple urinary metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS. | 8.5~11.5 hours (7-hour after lunch urine sample collected from 16:00 to 19:00PM) |