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This study evaluated the analgesic efficacy of fentanyl and dexamethasone in combination with bupivacaine for single-shot paravertebral block (PVB) in patients undergoing major breast surgery.
This study evaluated the analgesic efficacy of fentanyl and dexamethasone in combination with bupivacaine for single-shot paravertebral block (PVB) in patients undergoing major breast surgery.
Patients will receive ultrasound guided paravertebral block and stratified into 3 groups according to medication used :
Group 1 : bupivacaine (0.5%) 20 ml , fentanyl 1 μg/kg Group 2 : bupivacaine (0.5%) 20 ml , dexamethasone 4 mg Group 2 : bupivacaine (0.5%) 20 ml , fentanyl 1 μg/kg , dexamethasone 4 mg
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bupivacaine fentanyl group | Active Comparator | Patients will receive bupivacaine (0.5%) 20 ml , fentanyl 1 μg/kg in paravertebral block |
|
| Bupivacaine dexamethasone group | Active Comparator | Patients will receive bupivacaine (0.5%) 20 ml , dexamethasone 4 mg in paravertebral block |
|
| Bupivacaine fentanyl dexamethasone group | Active Comparator | Patients will receive bupivacaine (0.5%) 20 ml , fentanyl 1 μg/kg , dexamethasone 4 mg in paravertebral block |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fentanyl | Drug | Patients will receive bupivacaine (0.5%) 20 ml , fentanyl 1 μg/kg in paravertebral block |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to first analgesic request | one day postoperative | |
| pain assessment | Pain assessment by the aid of Visual analogue scale (VAS) Ranging from 0=no pain, 10=excruciating pain higher values represent worse outcome | one day postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Amonios khalil | Contact | 01023466456 | amonios_khalil@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Amonios khalil | Faculty of medicine-Assiut university-Egypt | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Amonios Khalil gerges | Recruiting | Asyut | Egypt |
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| ID | Term |
|---|---|
| D005283 | Fentanyl |
| D003907 | Dexamethasone |
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D011246 | Pregnadienetriols |
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Patients will receive ultrasound guided paravertebral block and stratified into 3 groups according to medication used :
Group 1 : bupivacaine (0.5%) 20 ml , fentanyl 1 μg/kg Group 2 : bupivacaine (0.5%) 20 ml , dexamethasone 4 mg Group 2 : bupivacaine (0.5%) 20 ml , fentanyl 1 μg/kg , dexamethasone 4 mg
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Randomization Will be Done Using Computer Generated Tables
| Dexamethasone | Drug | Patients will receive bupivacaine (0.5%) 20 ml , Dexamethasone 4mg in paravertebral block |
|
| Bupivacaine | Drug | Bupivacaine |
|
| D011245 |
| Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |