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| Name | Class |
|---|---|
| Hospital Universitario Virgen Macarena | OTHER |
| University Hospital Tuebingen | OTHER |
| University Hospital, Geneva | OTHER |
| UMC Utrecht |
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The continuing spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) is among the most important problems in antimicrobial resistance. It is also a good model to investigate the epidemiological complexity of resistance in Enterobacteriaceae. Available data on the transmission determinants of ESBL-PE in community settings are scarce, methodologically limited and mostly based on single centre studies. A comprehensive investigation using present typing and modelling techniques is warranted to develop a sound quantitative understanding of the interactions involved. A consortium of investigators with diverse expertise from countries with high and low endemicity of ESBL-EP has been created. Transmission and persistence of ESBL-PE within households and long-term care facilities will be studied. Individual and group-level determinants for transmission and persistence will be quantified, together with other ecological variables including environmental, food and wastewater contamination. Advanced molecular typing techniques and state of the art analytical methods will be used. Data generated in this project will directly inform a suite of mathematical models which, in addition to encapsulating current understanding of the processes, will be used to explore the potential effectiveness of different interventions to control ESBL-PE spread. The expected outputs are a comprehensive characterisation of ESBL-PE transmission considering bacterial clones and mobile genetic elements, as well as individual and ecologic-level factors in different settings, to inform public health authorities about interventions that should be prioritised to control transmission of these organisms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Long Term Care Facilities | Spread of ESBL-producing E. coli and K. pneumoniae among the residents of Long Term Care Facilities. |
| |
| Households | Household transmission of ESBL-producing bacteria after hospital discharge of a patient carrying ESBL-producing E. coli or K. pneumoniae. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ESBL-producing enterobacteriaceae carriage | Biological | Carriage of ESBL-producing Escherichia coli or Klebsiella pneumoniae |
|
| Measure | Description | Time Frame |
|---|---|---|
| Transmission of ESBL-producing E. coli and K. pneumoniae (ESBL-E) in the community (LTCF residents and in households) | We will assess
These two measurements will be aggregated to arrive at one reported value : the number of secondary cases from one index case (ratio). | For the cohort 'LTCF': 35 weeks ; For the cohort 'Household': 4 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Elise Robert | University Hospital of Besançon - France | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Besançon | Bourgogne-Franche-Comté | 25030 | France |
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| OTHER |
| University of Oxford | OTHER |
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Stool sample, environmental samples (wastewater, sinks, showers, food, toilets)
| ID | Term |
|---|---|
| D004756 | Enterobacteriaceae Infections |
| ID | Term |
|---|---|
| D016905 | Gram-Negative Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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