Fish oil and oily fish contain omega 3 long chain polyunsaturated fatty acids known to be beneficial to health. Many people consume little, despite UK government recommendations to eat at least one portion of oily fish per week. Furthermore, despite modest consumption, fish stocks are declining due to over fishing. Therefore, there is a need for an alternative, sustainable and cost efficiently produced dietary source. A seed oil source of these fish oil-type fatty acids has been achieved by adding genes from other plant sources to the oil seed plant Camelina sativa. Camelina sativa, related to mustard and cabbage, has provided seed oil for human consumption for thousands of years. It was the most important oil seed plant in Europe until the 1900's. This research is being done to see if consuming fish oil-type fatty acids in Camelina seed oil allows the body to take up and use the fish oil fatty acids in the same way as it does from fish oil.

This research is being done to see if consuming fish oil-type omega 3 long chain polyunsaturated fatty acids in Camelina seed oil allows the body to take up the fish oil fatty acids in the same way as it does from fish oil.

In the first study (A) the Camelina oil will be used in a meal. The volunteers (healthy men and women) will be asked to consume the meal and provide blood samples in the following 6 hours to look at immediate uptake of the fish oil fatty acids. This will be repeated (for comparison) with fish oil.

The second study (B) will look at consumption over a longer period. Volunteers will be asked to consume the Camelina oil daily for 8 weeks and provide blood samples at the visits at the start and end of that period. This will be repeated (for comparison) with fish oil.

Inclusion Criteria:

1. Male or female
2. 18 to 30 years or 50 to 65 years
3. Body mass index 18.5-30.0 kg/m2
4. Health screening results that are within normal clinical ranges
5. Not consuming fish oil or other oil supplements
6. Not eating more than one oily fish meal per week
7. Willing to adhere to the study protocol
8. Being able to provide written informed consent

Exclusion Criteria:

1. Aged < 18 years; 31-49 years or > 65 years
2. Body mass index < 18.5 or > 30 kg/m2
3. Current smoker
4. Fasting blood cholesterol or glucose concentrations outside the normal concentration range
5. Diagnosed chronic illness (for example diagnosed cardiovascular disease, diabetes, cancer)
6. Use of prescribed medicine to control inflammation
7. Use of prescribed medication to control blood lipids (e.g. statins, fibrates (fenofibrate), Omacor)
8. Use of prescribed medication to control blood pressure (ACE inhibitors, angiotensin 2 receptor blockers, calcium channel blockers, α-inhibitors, thiazide diuretics)
9. Use of fish oil or other oil supplements
10. Chronic gastrointestinal problems (e.g. IBD, coeliac disease, cancer)
11. Pregnant or planning to become pregnant within the study period
12. Participation in another clinical trial