Manual Versus Targer-controll Infusion in Reduction of Awareness and Dreaming

Reduction of Awareness and Dreaming During Neurosurgical Procedures Using Target- Controlled Infusion, Comparison With Manual Total Intravenous Anesthesia TIVA.

This study compares manual total intravenous anesthesia (TIVA) and target-controll infusion (TCI) in reduction of awareness and dreaming, and the haemodynamical stability during operation. Half of patients will be anesthetized using manual TIVA and other half using TCI.

Awareness is possible in TIVA in case of technical failure or prolonged induction phase, TCI technology seems to prevent these events. Total of 80 patients planed for elective neurosurgical brain tumor resection fulfilling the inclusion criteria will be devided into two groups. First half will be anesthetized using TIVA with manual induction and the second half will be anesthetized using TCI. All patients will fulfil Modified Brice Questionnaire one hour after the end of operation.

Inclusion Criteria:

• Glasgow Coma scale 15
• ASA Physical Status Classification System I - III
• planed surgery for brain tumor to 5 hours
• postoperative awakening

Exclusion Criteria:

• NYHA III, IV
• abuse of stimulating drugs, grass, alcohol dependence
• BMI over 40 in females and over 35 in men
• propofol alergie
• awake operations
• postoperative arteficial ventilation