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This study compares manual total intravenous anesthesia (TIVA) and target-controll infusion (TCI) in reduction of awareness and dreaming, and the haemodynamical stability during operation. Half of patients will be anesthetized using manual TIVA and other half using TCI.
Awareness is possible in TIVA in case of technical failure or prolonged induction phase, TCI technology seems to prevent these events. Total of 80 patients planed for elective neurosurgical brain tumor resection fulfilling the inclusion criteria will be devided into two groups. First half will be anesthetized using TIVA with manual induction and the second half will be anesthetized using TCI. All patients will fulfil Modified Brice Questionnaire one hour after the end of operation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group TCI | Experimental | induction and anesthesia will be held by using target-controll infusion |
|
| Group TIVA | Active Comparator | induction and anesthesia will be held by manual dosing of propofol and sufentanil |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Group TCI | Procedure | Induction and anesthesia will be done by using Gepth model for sufentanil and Schnider effect model for propofol. Anesthetics will be aplicated using infusion pump Agilia (Fresenius Kabi). Another titration will be according to target value of entropy between 40 and 60 and surgical pleth index below 35. |
| Measure | Description | Time Frame |
|---|---|---|
| reduction of awareness | consciousness during operation | 5 hours |
| Measure | Description | Time Frame |
|---|---|---|
| reduction of haemodynamical instability | reduction of blood pressure by 25 % | 5 hours |
| reduction of norepinephrine dose | reduction in ugs during the whole operation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Vlasta Dostalova, MD. Ph.D. | Contact | +420777883571 | vlasta.dostalova@fnhk.cz |
| Name | Affiliation | Role |
|---|---|---|
| Pavel Dostal, MD, Ph.D. | University Hospital Hradec Kralove | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Hradec Kralove | Recruiting | Hradec Králové | 50005 | Czechia |
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| ID | Term |
|---|---|
| D058926 | Intraoperative Awareness |
| ID | Term |
|---|---|
| D007431 | Intraoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Group A will be anesthetized using TIVA, group B using TCI
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|
| Group TIVA | Procedure | Induction of anesthesia will be done by titrating of propofol to the dose of 1.2 mg/kg and sufentanil 5-10 ug according to body weight, maintaining of anesthesia using continuous infusion of propofol 5 mg/ kg/hour and sufentanil 35 ug/hour to reach the target value of entropy between 40 and 60 and surgical pleth index below 35. |
|
| 5 hours |