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To evaluate the long-term complete remission rate (> 12 months) after endoscopic treatment of early neoplastic colorectal lesions.
Intra-mucous colorectal neoplasia lesions (or even with minimal mucosal infiltration), formerly treated surgically, are increasingly treated endoscopically.
The IPC as a center for interventional endoscopy has been taking care of these lesions for several years.
Resection techniques have diversified since the 2000s (polypectomy, monobloc or piecemeal mucosectomy, submucosal dissection ... etc) and the endoscopy team has developed its various techniques within the institute ; Practice has evolved and has not been studied or evaluated in recent years. The purpose of this study is to evaluate practices and to compare results with the literature, and to identify predictive factors for the failure or success of endoscopic treatment of these early neoplastic lesions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| endoscopic resection of a colorectal lesion | Patient having undergone endoscopic resection of a colorectal lesion stage 4 or 5 of the modified Vienna classification during the last 5 years at the institute. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Evaluation of the long-term complete remission rate (> 12 months) | Other | Evaluation of the long-term complete remission rate (> 12 months) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Complete long-term remission (> 12 months) | Evaluation of the long-term complete remission rate (> 12 months) | 13 months |
| Measure | Description | Time Frame |
|---|---|---|
| Absence of residual lesion on early control (3 to 6 months) | Medium-term response rate (3 to 6 months) | 3 to 6 months |
| Rates of medium and long-term recurrence | Recurrence rate in the medium and long term |
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Inclusion Criteria:
Exclusion Criteria:
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Patient having undergone endoscopic resection of a colorectal lesion stage 4 or 5 of the modified Vienna classification
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| Name | Affiliation | Role |
|---|---|---|
| Jean-Philippe RATONE | Institut Paoli-Calmettes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut Paoli Calmettes | Marseille | Bouches Du Rhone | 13009 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12077106 | Background | Dixon MF. Gastrointestinal epithelial neoplasia: Vienna revisited. Gut. 2002 Jul;51(1):130-1. doi: 10.1136/gut.51.1.130. | |
| 19617768 | Background | Repici A, Pellicano R, Strangio G, Danese S, Fagoonee S, Malesci A. Endoscopic mucosal resection for early colorectal neoplasia: pathologic basis, procedures, and outcomes. Dis Colon Rectum. 2009 Aug;52(8):1502-15. doi: 10.1007/DCR.0b013e3181a74d9b. |
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| 13 months |
| Management of medium and long-term recurrence | Management of recurrence (endoscopic revision or surgery) | 13 months |
| Morbidity and mortality rates | Morbidity and mortality rate of endoscopic resection | 13 months |
| Lymph node or visceral metastatic evolution rate | Rate of pejorative lymph node or metastatic evolution (especially for lesions with microinfiltration of the submucosa) | 13 months |
| Endoscopic description and anatomopathological results | Endoscopic and / or anatomopathological predictive factors of success (complete long-term remission) | 1 day |
| 24986245 | Background | Moss A, Williams SJ, Hourigan LF, Brown G, Tam W, Singh R, Zanati S, Burgess NG, Sonson R, Byth K, Bourke MJ. Long-term adenoma recurrence following wide-field endoscopic mucosal resection (WF-EMR) for advanced colonic mucosal neoplasia is infrequent: results and risk factors in 1000 cases from the Australian Colonic EMR (ACE) study. Gut. 2015 Jan;64(1):57-65. doi: 10.1136/gutjnl-2013-305516. Epub 2014 Jul 1. |
| 28212588 | Result | Ferlitsch M, Moss A, Hassan C, Bhandari P, Dumonceau JM, Paspatis G, Jover R, Langner C, Bronzwaer M, Nalankilli K, Fockens P, Hazzan R, Gralnek IM, Gschwantler M, Waldmann E, Jeschek P, Penz D, Heresbach D, Moons L, Lemmers A, Paraskeva K, Pohl J, Ponchon T, Regula J, Repici A, Rutter MD, Burgess NG, Bourke MJ. Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy. 2017 Mar;49(3):270-297. doi: 10.1055/s-0043-102569. Epub 2017 Feb 17. |
| 24671869 | Result | Belderbos TD, Leenders M, Moons LM, Siersema PD. Local recurrence after endoscopic mucosal resection of nonpedunculated colorectal lesions: systematic review and meta-analysis. Endoscopy. 2014 May;46(5):388-402. doi: 10.1055/s-0034-1364970. Epub 2014 Mar 26. |