Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Pre-gestational performance of hysterosalpingography (HSG) using an oil-soluble iodinated contrast medium has been demonstrated to be the main cause of excessive iodine exposure for pregnant women. However, its long-term health effects on the mothers and offsprings have not been adequately elucidated. A case registry study is designed to follow up all the pregnant women with pre-gestational history of ethiodized-oil HSG examination and try to keep track of maternal and fetal outcomes.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnant women with pre-gestational HSG history | All enrolled pregnant women with pre-gestational ethiodized-oil HSG will be followed up without grouping and be kept track for maternal and offspring's health outcomes in this case registry study. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dietary iodine restriction on subjects with iodine overload | Other | In this case registry study (observational study),all intervention will be performed not for research purposes, but only part of routine treatment, which will be recorded in database of the registry study. |
| Measure | Description | Time Frame |
|---|---|---|
| comprehensive pregnant outcomes_prevalence of gestational diabetes | prevalence of gestational diabetes | during the whole pregnancy, from date of verification of pregnancy until the date of termination of pregnancy, assessed up to 10 months |
| comprehensive pregnant outcomes_prevalence of gestational hypertension | prevalence of gestational hypertension | during the whole pregnancy, from date of verification of pregnancy until the date of termination of pregnancy, assessed up to 10 months |
| comprehensive pregnant outcomes_prevalence of abnormal pregnancy | prevalence of abnormal pregnancy (stillbirth, abortion, premature delivery) | during the whole pregnancy, from date of verification of pregnancy until the date of termination of pregnancy, assessed up to 10 months |
| comprehensive pregnant outcomes_rate of cesarean section | rate of cesarean section | at the time of delivery |
| comprehensive neonatal outcomes at delivery | Apgar scores of neonates | at the time of delivery |
| comprehensive neonatal outcomes_neonatal weight | birth weight of neonates | at the time of delivery |
| comprehensive neonatal outcomes_neonatal head circumference | head circumference of neonates |
| Measure | Description | Time Frame |
|---|---|---|
| prevalence of thyroid dysfunction in pregnancy | evaluation of maternal TSH, T3, T4, FT3, FT4, TRAb,Tg-Ab, TPO-Ab | during the whole pregnancy, from date of verification of pregnancy until the date of termination of pregnancy, assessed up to 10 months |
| prevalence of iodine overload in neonates |
Not provided
Inclusion Criteria:
Must be pregnant when enrolled in this study. Must have undergone examination of ethiodized-oil HSG before this pregnancy. Clinical diagnosis of iodine excess (with the mean urine iodine concentration ≥250μg/L and the serum iodine concentration >92μg/L).
Exclusion Criteria:
Having past history of partial or total resection of thyroid glands. Having medical history of thyroid dysfunction before ethiodized-oil HSG examination.
Not provided
Not provided
Pregnant women with excessive iodine exposure caused by pre-gestational ethiodized-oil HSG
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rongrong Li | Contact | +861069159088 | lirongrong0331@163.com |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| at the time of delivery |
| comprehensive neonatal outcomes_neonatal height | height of neonates | at the time of delivery |
| comprehensive neonatal outcomes_neonatal BMI | BMI of neonates | at the time of delivery |
| comprehensive neonatal outcomes_prevalence of macrosomia or underweight | prevalence of macrosomia or underweight | at the time of delivery |
| offspring outcomes_prevalence of thyroid dysfunction | prevalence of thyroid dysfunction (hyperthyroidism or hypothyroidism) | from birth to age of 1 year old, assessed every 6 months |
| offspring outcomes_neurodevelopment evaluation in long term | Norwegian version of the Ages and Stages Questionnaire (ASQ) scores for evaluation of infant neurodevelopment | from birth to age of 1 year old, assessed every 6 months |
| comprehensive offspring outcomes in long term - weight evaluation | weight of offsprings | from birth to age of 1 year old, assessed every 3-6 months |
| comprehensive offspring outcomes in long term - height evaluation | height of offsprings | from birth to age of 1 year old, assessed every 3-6 months |
| comprehensive offspring outcomes in long term - BMI evaluation | BMI of offsprings | from birth to age of 1 year old, assessed every 3-6 months |
prevalence of infants with urinary iodine concentration ≥200μg/L |
| within 1 week after birth of neonates |